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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-28614577-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=28614577&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 28614577,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000354911.9",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1448C>T",
"hgvs_p": "p.Pro483Leu",
"transcript": "NM_016628.5",
"protein_id": "NP_057712.2",
"transcript_support_level": null,
"aa_start": 483,
"aa_end": null,
"aa_length": 647,
"cds_start": 1448,
"cds_end": null,
"cds_length": 1944,
"cdna_start": 1910,
"cdna_end": null,
"cdna_length": 5912,
"mane_select": "ENST00000354911.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1448C>T",
"hgvs_p": "p.Pro483Leu",
"transcript": "ENST00000354911.9",
"protein_id": "ENSP00000346986.4",
"transcript_support_level": 1,
"aa_start": 483,
"aa_end": null,
"aa_length": 647,
"cds_start": 1448,
"cds_end": null,
"cds_length": 1944,
"cdna_start": 1910,
"cdna_end": null,
"cdna_length": 5912,
"mane_select": "NM_016628.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1313C>T",
"hgvs_p": "p.Pro438Leu",
"transcript": "ENST00000375664.8",
"protein_id": "ENSP00000364816.3",
"transcript_support_level": 1,
"aa_start": 438,
"aa_end": null,
"aa_length": 602,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1809,
"cdna_start": 1922,
"cdna_end": null,
"cdna_length": 5924,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "n.2189C>T",
"hgvs_p": null,
"transcript": "ENST00000345541.6",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4526,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "n.*874C>T",
"hgvs_p": null,
"transcript": "ENST00000628285.3",
"protein_id": "ENSP00000486994.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3513,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "n.*874C>T",
"hgvs_p": null,
"transcript": "ENST00000628285.3",
"protein_id": "ENSP00000486994.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3513,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1436C>T",
"hgvs_p": "p.Pro479Leu",
"transcript": "ENST00000700325.1",
"protein_id": "ENSP00000514952.1",
"transcript_support_level": null,
"aa_start": 479,
"aa_end": null,
"aa_length": 643,
"cds_start": 1436,
"cds_end": null,
"cds_length": 1932,
"cdna_start": 1762,
"cdna_end": null,
"cdna_length": 2597,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1436C>T",
"hgvs_p": "p.Pro479Leu",
"transcript": "ENST00000706612.1",
"protein_id": "ENSP00000516469.1",
"transcript_support_level": null,
"aa_start": 479,
"aa_end": null,
"aa_length": 643,
"cds_start": 1436,
"cds_end": null,
"cds_length": 1932,
"cdna_start": 1908,
"cdna_end": null,
"cdna_length": 5910,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1319C>T",
"hgvs_p": "p.Pro440Leu",
"transcript": "ENST00000680735.1",
"protein_id": "ENSP00000505513.1",
"transcript_support_level": null,
"aa_start": 440,
"aa_end": null,
"aa_length": 604,
"cds_start": 1319,
"cds_end": null,
"cds_length": 1815,
"cdna_start": 1920,
"cdna_end": null,
"cdna_length": 5922,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1313C>T",
"hgvs_p": "p.Pro438Leu",
"transcript": "NM_100264.3",
"protein_id": "NP_567822.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 602,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1809,
"cdna_start": 1636,
"cdna_end": null,
"cdna_length": 5638,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1313C>T",
"hgvs_p": "p.Pro438Leu",
"transcript": "ENST00000442148.6",
"protein_id": "ENSP00000400848.2",
"transcript_support_level": 5,
"aa_start": 438,
"aa_end": null,
"aa_length": 602,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1809,
"cdna_start": 1552,
"cdna_end": null,
"cdna_length": 5554,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1313C>T",
"hgvs_p": "p.Pro438Leu",
"transcript": "ENST00000679398.1",
"protein_id": "ENSP00000506624.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 602,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1809,
"cdna_start": 1484,
"cdna_end": null,
"cdna_length": 5486,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1313C>T",
"hgvs_p": "p.Pro438Leu",
"transcript": "ENST00000679428.1",
"protein_id": "ENSP00000506445.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 602,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1809,
"cdna_start": 1430,
"cdna_end": null,
"cdna_length": 5432,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1139C>T",
"hgvs_p": "p.Pro380Leu",
"transcript": "NM_100486.4",
"protein_id": "NP_567823.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 544,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1635,
"cdna_start": 1601,
"cdna_end": null,
"cdna_length": 5603,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1139C>T",
"hgvs_p": "p.Pro380Leu",
"transcript": "ENST00000347934.8",
"protein_id": "ENSP00000311106.4",
"transcript_support_level": 5,
"aa_start": 380,
"aa_end": null,
"aa_length": 544,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1635,
"cdna_start": 1406,
"cdna_end": null,
"cdna_length": 2839,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.992C>T",
"hgvs_p": "p.Pro331Leu",
"transcript": "ENST00000375646.5",
"protein_id": "ENSP00000364797.1",
"transcript_support_level": 5,
"aa_start": 331,
"aa_end": null,
"aa_length": 495,
"cds_start": 992,
"cds_end": null,
"cds_length": 1488,
"cdna_start": 1310,
"cdna_end": null,
"cdna_length": 2176,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1694C>T",
"hgvs_p": "p.Pro565Leu",
"transcript": "XM_047425309.1",
"protein_id": "XP_047281265.1",
"transcript_support_level": null,
"aa_start": 565,
"aa_end": null,
"aa_length": 729,
"cds_start": 1694,
"cds_end": null,
"cds_length": 2190,
"cdna_start": 2020,
"cdna_end": null,
"cdna_length": 6022,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1586C>T",
"hgvs_p": "p.Pro529Leu",
"transcript": "XM_047425310.1",
"protein_id": "XP_047281266.1",
"transcript_support_level": null,
"aa_start": 529,
"aa_end": null,
"aa_length": 693,
"cds_start": 1586,
"cds_end": null,
"cds_length": 2082,
"cdna_start": 2058,
"cdna_end": null,
"cdna_length": 6060,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1586C>T",
"hgvs_p": "p.Pro529Leu",
"transcript": "XM_047425311.1",
"protein_id": "XP_047281267.1",
"transcript_support_level": null,
"aa_start": 529,
"aa_end": null,
"aa_length": 692,
"cds_start": 1586,
"cds_end": null,
"cds_length": 2079,
"cdna_start": 2058,
"cdna_end": null,
"cdna_length": 6057,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1466C>T",
"hgvs_p": "p.Pro489Leu",
"transcript": "XM_047425312.1",
"protein_id": "XP_047281268.1",
"transcript_support_level": null,
"aa_start": 489,
"aa_end": null,
"aa_length": 653,
"cds_start": 1466,
"cds_end": null,
"cds_length": 1962,
"cdna_start": 1928,
"cdna_end": null,
"cdna_length": 5930,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1448C>T",
"hgvs_p": "p.Pro483Leu",
"transcript": "XM_047425313.1",
"protein_id": "XP_047281269.1",
"transcript_support_level": null,
"aa_start": 483,
"aa_end": null,
"aa_length": 646,
"cds_start": 1448,
"cds_end": null,
"cds_length": 1941,
"cdna_start": 1910,
"cdna_end": null,
"cdna_length": 5909,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1385C>T",
"hgvs_p": "p.Pro462Leu",
"transcript": "XM_047425314.1",
"protein_id": "XP_047281270.1",
"transcript_support_level": null,
"aa_start": 462,
"aa_end": null,
"aa_length": 626,
"cds_start": 1385,
"cds_end": null,
"cds_length": 1881,
"cdna_start": 1711,
"cdna_end": null,
"cdna_length": 5713,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WAC",
"gene_hgnc_id": 17327,
"hgvs_c": "c.1313C>T",
"hgvs_p": "p.Pro438Leu",
"transcript": "XM_047425315.1",
"protein_id": "XP_047281271.1",
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}