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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 10-30845359-C-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=30845359&ref=C&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "10",
      "pos": 30845359,
      "ref": "C",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_182755.3",
      "consequences": [
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "NM_001143768.2",
          "protein_id": "NP_001137240.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000436087.7",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001143768.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "ENST00000436087.7",
          "protein_id": "ENSP00000406934.2",
          "transcript_support_level": 5,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_001143768.2",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000436087.7"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "ENST00000361310.7",
          "protein_id": "ENSP00000354663.3",
          "transcript_support_level": 1,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000361310.7"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2059G>T",
          "hgvs_p": "p.Ala687Ser",
          "transcript": "ENST00000331737.10",
          "protein_id": "ENSP00000333571.6",
          "transcript_support_level": 1,
          "aa_start": 687,
          "aa_end": null,
          "aa_length": 818,
          "cds_start": 2059,
          "cds_end": null,
          "cds_length": 2457,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000331737.10"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "NM_001143766.2",
          "protein_id": "NP_001137238.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001143766.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "NM_001143767.2",
          "protein_id": "NP_001137239.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001143767.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "NM_001387405.1",
          "protein_id": "NP_001374334.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001387405.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "NM_001387411.1",
          "protein_id": "NP_001374340.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001387411.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "NM_001387412.1",
          "protein_id": "NP_001374341.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001387412.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "NM_182755.3",
          "protein_id": "NP_877432.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_182755.3"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "ENST00000413025.5",
          "protein_id": "ENSP00000387546.1",
          "transcript_support_level": 5,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000413025.5"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "ENST00000442986.5",
          "protein_id": "ENSP00000412363.1",
          "transcript_support_level": 5,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000442986.5"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "ENST00000885964.1",
          "protein_id": "ENSP00000556023.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000885964.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "ENST00000885965.1",
          "protein_id": "ENSP00000556024.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000885965.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "ENST00000885966.1",
          "protein_id": "ENSP00000556025.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000885966.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "ENST00000885967.1",
          "protein_id": "ENSP00000556026.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000885967.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "ENST00000885968.1",
          "protein_id": "ENSP00000556027.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000885968.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "ENST00000885969.1",
          "protein_id": "ENSP00000556028.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000885969.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "ENST00000885970.1",
          "protein_id": "ENSP00000556029.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000885970.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF438",
          "gene_hgnc_id": 21029,
          "hgvs_c": "c.2089G>T",
          "hgvs_p": "p.Ala697Ser",
          "transcript": "ENST00000885971.1",
          "protein_id": "ENSP00000556030.1",
          "transcript_support_level": null,
          "aa_start": 697,
          "aa_end": null,
          "aa_length": 828,
          "cds_start": 2089,
          "cds_end": null,
          "cds_length": 2487,
          "cdna_start": null,
          "cdna_end": null,
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      "clinvar_disease": "",
      "clinvar_classification": "",
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      "custom_annotations": null
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  "message": null
}