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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-31521854-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=31521854&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 31521854,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000424869.6",
"consequences": [
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2522A>G",
"hgvs_p": "p.Gln841Arg",
"transcript": "NM_001174096.2",
"protein_id": "NP_001167567.1",
"transcript_support_level": null,
"aa_start": 841,
"aa_end": null,
"aa_length": 1125,
"cds_start": 2522,
"cds_end": null,
"cds_length": 3378,
"cdna_start": 2541,
"cdna_end": null,
"cdna_length": 5937,
"mane_select": "ENST00000424869.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2522A>G",
"hgvs_p": "p.Gln841Arg",
"transcript": "ENST00000424869.6",
"protein_id": "ENSP00000415961.2",
"transcript_support_level": 5,
"aa_start": 841,
"aa_end": null,
"aa_length": 1125,
"cds_start": 2522,
"cds_end": null,
"cds_length": 3378,
"cdna_start": 2541,
"cdna_end": null,
"cdna_length": 5937,
"mane_select": "NM_001174096.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2519A>G",
"hgvs_p": "p.Gln840Arg",
"transcript": "ENST00000320985.14",
"protein_id": "ENSP00000319248.9",
"transcript_support_level": 1,
"aa_start": 840,
"aa_end": null,
"aa_length": 1124,
"cds_start": 2519,
"cds_end": null,
"cds_length": 3375,
"cdna_start": 2629,
"cdna_end": null,
"cdna_length": 5423,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "n.*2659A>G",
"hgvs_p": null,
"transcript": "ENST00000437844.6",
"protein_id": "ENSP00000405958.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6246,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "n.3232A>G",
"hgvs_p": null,
"transcript": "ENST00000488625.6",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6026,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "n.2588A>G",
"hgvs_p": null,
"transcript": "ENST00000559858.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2745,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "n.*2659A>G",
"hgvs_p": null,
"transcript": "ENST00000437844.6",
"protein_id": "ENSP00000405958.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6246,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2519A>G",
"hgvs_p": "p.Gln840Arg",
"transcript": "NM_030751.6",
"protein_id": "NP_110378.3",
"transcript_support_level": null,
"aa_start": 840,
"aa_end": null,
"aa_length": 1124,
"cds_start": 2519,
"cds_end": null,
"cds_length": 3375,
"cdna_start": 2538,
"cdna_end": null,
"cdna_length": 5934,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2480A>G",
"hgvs_p": "p.Gln827Arg",
"transcript": "NM_001323676.2",
"protein_id": "NP_001310605.1",
"transcript_support_level": null,
"aa_start": 827,
"aa_end": null,
"aa_length": 1111,
"cds_start": 2480,
"cds_end": null,
"cds_length": 3336,
"cdna_start": 2656,
"cdna_end": null,
"cdna_length": 6052,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2477A>G",
"hgvs_p": "p.Gln826Arg",
"transcript": "NM_001323677.2",
"protein_id": "NP_001310606.1",
"transcript_support_level": null,
"aa_start": 826,
"aa_end": null,
"aa_length": 1110,
"cds_start": 2477,
"cds_end": null,
"cds_length": 3333,
"cdna_start": 2653,
"cdna_end": null,
"cdna_length": 6049,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2471A>G",
"hgvs_p": "p.Gln824Arg",
"transcript": "NM_001128128.3",
"protein_id": "NP_001121600.1",
"transcript_support_level": null,
"aa_start": 824,
"aa_end": null,
"aa_length": 1108,
"cds_start": 2471,
"cds_end": null,
"cds_length": 3327,
"cdna_start": 2796,
"cdna_end": null,
"cdna_length": 6192,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2471A>G",
"hgvs_p": "p.Gln824Arg",
"transcript": "ENST00000446923.7",
"protein_id": "ENSP00000391612.2",
"transcript_support_level": 5,
"aa_start": 824,
"aa_end": null,
"aa_length": 1108,
"cds_start": 2471,
"cds_end": null,
"cds_length": 3327,
"cdna_start": 2845,
"cdna_end": null,
"cdna_length": 6250,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2468A>G",
"hgvs_p": "p.Gln823Arg",
"transcript": "NM_001174094.2",
"protein_id": "NP_001167565.1",
"transcript_support_level": null,
"aa_start": 823,
"aa_end": null,
"aa_length": 1107,
"cds_start": 2468,
"cds_end": null,
"cds_length": 3324,
"cdna_start": 2793,
"cdna_end": null,
"cdna_length": 6189,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2459A>G",
"hgvs_p": "p.Gln820Arg",
"transcript": "NM_001174093.2",
"protein_id": "NP_001167564.1",
"transcript_support_level": null,
"aa_start": 820,
"aa_end": null,
"aa_length": 1104,
"cds_start": 2459,
"cds_end": null,
"cds_length": 3315,
"cdna_start": 2478,
"cdna_end": null,
"cdna_length": 5874,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2459A>G",
"hgvs_p": "p.Gln820Arg",
"transcript": "ENST00000560721.6",
"protein_id": "ENSP00000452787.1",
"transcript_support_level": 2,
"aa_start": 820,
"aa_end": null,
"aa_length": 1104,
"cds_start": 2459,
"cds_end": null,
"cds_length": 3315,
"cdna_start": 2482,
"cdna_end": null,
"cdna_length": 3368,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2318A>G",
"hgvs_p": "p.Gln773Arg",
"transcript": "NM_001174095.2",
"protein_id": "NP_001167566.1",
"transcript_support_level": null,
"aa_start": 773,
"aa_end": null,
"aa_length": 1057,
"cds_start": 2318,
"cds_end": null,
"cds_length": 3174,
"cdna_start": 2337,
"cdna_end": null,
"cdna_length": 5733,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2318A>G",
"hgvs_p": "p.Gln773Arg",
"transcript": "ENST00000542815.7",
"protein_id": "ENSP00000444891.2",
"transcript_support_level": 2,
"aa_start": 773,
"aa_end": null,
"aa_length": 1057,
"cds_start": 2318,
"cds_end": null,
"cds_length": 3174,
"cdna_start": 2331,
"cdna_end": null,
"cdna_length": 3217,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2297A>G",
"hgvs_p": "p.Gln766Arg",
"transcript": "NM_001323674.2",
"protein_id": "NP_001310603.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 1050,
"cds_start": 2297,
"cds_end": null,
"cds_length": 3153,
"cdna_start": 2316,
"cdna_end": null,
"cdna_length": 5712,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2255A>G",
"hgvs_p": "p.Gln752Arg",
"transcript": "NM_001323675.2",
"protein_id": "NP_001310604.1",
"transcript_support_level": null,
"aa_start": 752,
"aa_end": null,
"aa_length": 1036,
"cds_start": 2255,
"cds_end": null,
"cds_length": 3111,
"cdna_start": 2431,
"cdna_end": null,
"cdna_length": 5827,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.2246A>G",
"hgvs_p": "p.Gln749Arg",
"transcript": "NM_001323678.2",
"protein_id": "NP_001310607.1",
"transcript_support_level": null,
"aa_start": 749,
"aa_end": null,
"aa_length": 1033,
"cds_start": 2246,
"cds_end": null,
"cds_length": 3102,
"cdna_start": 2571,
"cdna_end": null,
"cdna_length": 5967,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.1865A>G",
"hgvs_p": "p.Gln622Arg",
"transcript": "NM_001323638.2",
"protein_id": "NP_001310567.1",
"transcript_support_level": null,
"aa_start": 622,
"aa_end": null,
"aa_length": 906,
"cds_start": 1865,
"cds_end": null,
"cds_length": 2721,
"cdna_start": 3310,
"cdna_end": null,
"cdna_length": 6706,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
"hgvs_c": "c.1865A>G",
"hgvs_p": "p.Gln622Arg",
"transcript": "NM_001323641.2",
"protein_id": "NP_001310570.1",
"transcript_support_level": null,
"aa_start": 622,
"aa_end": null,
"aa_length": 906,
"cds_start": 1865,
"cds_end": null,
"cds_length": 2721,
"cdna_start": 2777,
"cdna_end": null,
"cdna_length": 6173,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZEB1",
"gene_hgnc_id": 11642,
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