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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-32567517-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=32567517&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 32567517,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000639629.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 44,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "CCDC7",
"gene_hgnc_id": 26533,
"hgvs_c": "c.1198-153A>G",
"hgvs_p": null,
"transcript": "NM_001395015.1",
"protein_id": "NP_001381944.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1385,
"cds_start": -4,
"cds_end": null,
"cds_length": 4158,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4826,
"mane_select": "ENST00000639629.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 44,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "CCDC7",
"gene_hgnc_id": 26533,
"hgvs_c": "c.1198-153A>G",
"hgvs_p": null,
"transcript": "ENST00000639629.2",
"protein_id": "ENSP00000491655.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1385,
"cds_start": -4,
"cds_end": null,
"cds_length": 4158,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4826,
"mane_select": "NM_001395015.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "CCDC7",
"gene_hgnc_id": 26533,
"hgvs_c": "c.1198-153A>G",
"hgvs_p": null,
"transcript": "ENST00000277657.12",
"protein_id": "ENSP00000277657.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 486,
"cds_start": -4,
"cds_end": null,
"cds_length": 1461,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1899,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "CCDC7",
"gene_hgnc_id": 26533,
"hgvs_c": "c.1198-153A>G",
"hgvs_p": null,
"transcript": "ENST00000362006.11",
"protein_id": "ENSP00000355078.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 486,
"cds_start": -4,
"cds_end": null,
"cds_length": 1461,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2133,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 44,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "CCDC7",
"gene_hgnc_id": 26533,
"hgvs_c": "c.1198-153A>G",
"hgvs_p": null,
"transcript": "NM_001321115.2",
"protein_id": "NP_001308044.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1385,
"cds_start": -4,
"cds_end": null,
"cds_length": 4158,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5060,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "CCDC7",
"gene_hgnc_id": 26533,
"hgvs_c": "c.681+1897A>G",
"hgvs_p": null,
"transcript": "NM_001395233.1",
"protein_id": "NP_001382162.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 505,
"cds_start": -4,
"cds_end": null,
"cds_length": 1518,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3902,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "CCDC7",
"gene_hgnc_id": 26533,
"hgvs_c": "c.1198-153A>G",
"hgvs_p": null,
"transcript": "NM_001026383.3",
"protein_id": "NP_001021554.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 486,
"cds_start": -4,
"cds_end": null,
"cds_length": 1461,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1896,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "CCDC7",
"gene_hgnc_id": 26533,
"hgvs_c": "c.1198-153A>G",
"hgvs_p": null,
"transcript": "NM_145023.6",
"protein_id": "NP_659460.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 486,
"cds_start": -4,
"cds_end": null,
"cds_length": 1461,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2130,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "CCDC7",
"gene_hgnc_id": 26533,
"hgvs_c": "c.205-153A>G",
"hgvs_p": null,
"transcript": "ENST00000639041.1",
"protein_id": "ENSP00000490962.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 159,
"cds_start": -4,
"cds_end": null,
"cds_length": 482,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 482,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "CCDC7",
"gene_hgnc_id": 26533,
"hgvs_c": "n.*318-153A>G",
"hgvs_p": null,
"transcript": "ENST00000476558.7",
"protein_id": "ENSP00000436435.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 1819,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "CCDC7",
"gene_hgnc_id": 26533,
"hgvs_c": "n.1431-153A>G",
"hgvs_p": null,
"transcript": "NR_109826.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 44,
"intron_rank": 15,
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"gene_symbol": "CCDC7",
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"hgvs_c": "c.1198-153A>G",
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"transcript": "XM_047425742.1",
"protein_id": "XP_047281698.1",
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"feature": null
},
{
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"strand": true,
"consequences": [
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],
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"gene_symbol": "CCDC7",
"gene_hgnc_id": 26533,
"hgvs_c": "c.1198-153A>G",
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"transcript": "XM_047425743.1",
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},
{
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"strand": true,
"consequences": [
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],
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"intron_rank": 15,
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"gene_symbol": "CCDC7",
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"hgvs_c": "c.1198-153A>G",
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"transcript": "XM_011519664.1",
"protein_id": "XP_011517966.1",
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},
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],
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"gene_symbol": "CCDC7",
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"hgvs_c": "c.1177-153A>G",
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"transcript": "XM_024448165.1",
"protein_id": "XP_024303933.1",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": 14,
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"gene_symbol": "CCDC7",
"gene_hgnc_id": 26533,
"hgvs_c": "c.1165-153A>G",
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"transcript": "XM_024448166.1",
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},
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],
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"gene_symbol": "CCDC7",
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"hgvs_c": "c.1198-153A>G",
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"transcript": "XM_017016638.1",
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},
{
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],
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"intron_rank": 15,
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"gene_symbol": "CCDC7",
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"hgvs_c": "c.1198-153A>G",
"hgvs_p": null,
"transcript": "XM_011519666.1",
"protein_id": "XP_011517968.1",
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},
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 43,
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"gene_symbol": "CCDC7",
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"hgvs_c": "c.1198-153A>G",
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},
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},
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],
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"gene_symbol": "CCDC7",
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},
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"consequences": [
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],
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"gene_symbol": "CCDC7",
"gene_hgnc_id": 26533,
"hgvs_c": "c.1198-153A>G",
"hgvs_p": null,
"transcript": "XM_011519670.1",
"protein_id": "XP_011517972.1",
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"feature": null
},
{
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"strand": true,
"consequences": [
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],
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"exon_count": 43,
"intron_rank": 15,
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"gene_symbol": "CCDC7",
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"hgvs_c": "c.1198-153A>G",
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"transcript": "XM_011519671.1",
"protein_id": "XP_011517973.1",
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}
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}