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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 10-32911539-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=32911539&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "10",
      "pos": 32911539,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_033668.2",
      "consequences": [
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1840G>A",
          "hgvs_p": "p.Glu614Lys",
          "transcript": "NM_002211.4",
          "protein_id": "NP_002202.2",
          "transcript_support_level": null,
          "aa_start": 614,
          "aa_end": null,
          "aa_length": 798,
          "cds_start": 1840,
          "cds_end": null,
          "cds_length": 2397,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000302278.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_002211.4"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1840G>A",
          "hgvs_p": "p.Glu614Lys",
          "transcript": "ENST00000302278.8",
          "protein_id": "ENSP00000303351.3",
          "transcript_support_level": 1,
          "aa_start": 614,
          "aa_end": null,
          "aa_length": 798,
          "cds_start": 1840,
          "cds_end": null,
          "cds_length": 2397,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_002211.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000302278.8"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1669G>A",
          "hgvs_p": "p.Glu557Lys",
          "transcript": "ENST00000488427.2",
          "protein_id": "ENSP00000417508.2",
          "transcript_support_level": 1,
          "aa_start": 557,
          "aa_end": null,
          "aa_length": 741,
          "cds_start": 1669,
          "cds_end": null,
          "cds_length": 2226,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000488427.2"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.2077G>A",
          "hgvs_p": "p.Glu693Lys",
          "transcript": "ENST00000966597.1",
          "protein_id": "ENSP00000636656.1",
          "transcript_support_level": null,
          "aa_start": 693,
          "aa_end": null,
          "aa_length": 877,
          "cds_start": 2077,
          "cds_end": null,
          "cds_length": 2634,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000966597.1"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1840G>A",
          "hgvs_p": "p.Glu614Lys",
          "transcript": "ENST00000677310.2",
          "protein_id": "ENSP00000504508.1",
          "transcript_support_level": null,
          "aa_start": 614,
          "aa_end": null,
          "aa_length": 825,
          "cds_start": 1840,
          "cds_end": null,
          "cds_length": 2478,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000677310.2"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1840G>A",
          "hgvs_p": "p.Glu614Lys",
          "transcript": "ENST00000678766.1",
          "protein_id": "ENSP00000503538.1",
          "transcript_support_level": null,
          "aa_start": 614,
          "aa_end": null,
          "aa_length": 825,
          "cds_start": 1840,
          "cds_end": null,
          "cds_length": 2478,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000678766.1"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1840G>A",
          "hgvs_p": "p.Glu614Lys",
          "transcript": "ENST00000676659.1",
          "protein_id": "ENSP00000502979.1",
          "transcript_support_level": null,
          "aa_start": 614,
          "aa_end": null,
          "aa_length": 819,
          "cds_start": 1840,
          "cds_end": null,
          "cds_length": 2460,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000676659.1"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1864G>A",
          "hgvs_p": "p.Glu622Lys",
          "transcript": "ENST00000474568.6",
          "protein_id": "ENSP00000420282.2",
          "transcript_support_level": 5,
          "aa_start": 622,
          "aa_end": null,
          "aa_length": 809,
          "cds_start": 1864,
          "cds_end": null,
          "cds_length": 2430,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000474568.6"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1864G>A",
          "hgvs_p": "p.Glu622Lys",
          "transcript": "ENST00000677363.1",
          "protein_id": "ENSP00000504791.1",
          "transcript_support_level": null,
          "aa_start": 622,
          "aa_end": null,
          "aa_length": 809,
          "cds_start": 1864,
          "cds_end": null,
          "cds_length": 2430,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000677363.1"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1873G>A",
          "hgvs_p": "p.Glu625Lys",
          "transcript": "ENST00000898627.1",
          "protein_id": "ENSP00000568686.1",
          "transcript_support_level": null,
          "aa_start": 625,
          "aa_end": null,
          "aa_length": 809,
          "cds_start": 1873,
          "cds_end": null,
          "cds_length": 2430,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000898627.1"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1870G>A",
          "hgvs_p": "p.Glu624Lys",
          "transcript": "ENST00000966589.1",
          "protein_id": "ENSP00000636648.1",
          "transcript_support_level": null,
          "aa_start": 624,
          "aa_end": null,
          "aa_length": 808,
          "cds_start": 1870,
          "cds_end": null,
          "cds_length": 2427,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000966589.1"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1861G>A",
          "hgvs_p": "p.Glu621Lys",
          "transcript": "ENST00000898622.1",
          "protein_id": "ENSP00000568681.1",
          "transcript_support_level": null,
          "aa_start": 621,
          "aa_end": null,
          "aa_length": 805,
          "cds_start": 1861,
          "cds_end": null,
          "cds_length": 2418,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000898622.1"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1840G>A",
          "hgvs_p": "p.Glu614Lys",
          "transcript": "NM_033668.2",
          "protein_id": "NP_391988.1",
          "transcript_support_level": null,
          "aa_start": 614,
          "aa_end": null,
          "aa_length": 801,
          "cds_start": 1840,
          "cds_end": null,
          "cds_length": 2406,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_033668.2"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1840G>A",
          "hgvs_p": "p.Glu614Lys",
          "transcript": "ENST00000423113.6",
          "protein_id": "ENSP00000388694.1",
          "transcript_support_level": 5,
          "aa_start": 614,
          "aa_end": null,
          "aa_length": 801,
          "cds_start": 1840,
          "cds_end": null,
          "cds_length": 2406,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000423113.6"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1849G>A",
          "hgvs_p": "p.Glu617Lys",
          "transcript": "ENST00000488494.6",
          "protein_id": "ENSP00000418725.2",
          "transcript_support_level": 4,
          "aa_start": 617,
          "aa_end": null,
          "aa_length": 801,
          "cds_start": 1849,
          "cds_end": null,
          "cds_length": 2406,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000488494.6"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1840G>A",
          "hgvs_p": "p.Glu614Lys",
          "transcript": "NM_133376.3",
          "protein_id": "NP_596867.1",
          "transcript_support_level": null,
          "aa_start": 614,
          "aa_end": null,
          "aa_length": 798,
          "cds_start": 1840,
          "cds_end": null,
          "cds_length": 2397,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_133376.3"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1840G>A",
          "hgvs_p": "p.Glu614Lys",
          "transcript": "ENST00000396033.6",
          "protein_id": "ENSP00000379350.2",
          "transcript_support_level": 5,
          "aa_start": 614,
          "aa_end": null,
          "aa_length": 798,
          "cds_start": 1840,
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          "cds_length": 2397,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000396033.6"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1840G>A",
          "hgvs_p": "p.Glu614Lys",
          "transcript": "ENST00000417122.7",
          "protein_id": "ENSP00000404546.3",
          "transcript_support_level": 4,
          "aa_start": 614,
          "aa_end": null,
          "aa_length": 798,
          "cds_start": 1840,
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          "cds_length": 2397,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000417122.7"
        },
        {
          "aa_ref": "E",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1840G>A",
          "hgvs_p": "p.Glu614Lys",
          "transcript": "ENST00000437302.6",
          "protein_id": "ENSP00000398029.2",
          "transcript_support_level": 5,
          "aa_start": 614,
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          "cds_start": 1840,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000437302.6"
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "c.1840G>A",
          "hgvs_p": "p.Glu614Lys",
          "transcript": "ENST00000677999.1",
          "protein_id": "ENSP00000503546.1",
          "transcript_support_level": null,
          "aa_start": 614,
          "aa_end": null,
          "aa_length": 798,
          "cds_start": 1840,
          "cds_end": null,
          "cds_length": 2397,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
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          "gene_symbol": "ITGB1",
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          "hgvs_c": "n.1840G>A",
          "hgvs_p": null,
          "transcript": "ENST00000678989.1",
          "protein_id": "ENSP00000502882.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000678989.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "n.*829G>A",
          "hgvs_p": null,
          "transcript": "ENST00000676895.1",
          "protein_id": "ENSP00000504454.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000676895.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "n.*712G>A",
          "hgvs_p": null,
          "transcript": "ENST00000678120.1",
          "protein_id": "ENSP00000504784.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000678120.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ITGB1",
          "gene_hgnc_id": 6153,
          "hgvs_c": "n.*1646G>A",
          "hgvs_p": null,
          "transcript": "ENST00000678479.1",
          "protein_id": "ENSP00000503110.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000678479.1"
        }
      ],
      "gene_symbol": "ITGB1",
      "gene_hgnc_id": 6153,
      "dbsnp": "rs140200196",
      "frequency_reference_population": 0.000042129992,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 68,
      "gnomad_exomes_af": 0.0000437801,
      "gnomad_genomes_af": 0.0000262812,
      "gnomad_exomes_ac": 64,
      "gnomad_genomes_ac": 4,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.6177361011505127,
      "computational_prediction_selected": "Uncertain_significance",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.595,
      "revel_prediction": "Uncertain_significance",
      "alphamissense_score": 0.1908,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": 0.04,
      "bayesdelnoaf_prediction": "Uncertain_significance",
      "phylop100way_score": 4.965,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -4,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BS2",
      "acmg_by_gene": [
        {
          "score": -4,
          "benign_score": 4,
          "pathogenic_score": 0,
          "criteria": [
            "BS2"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_033668.2",
          "gene_symbol": "ITGB1",
          "hgnc_id": 6153,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.1840G>A",
          "hgvs_p": "p.Glu614Lys"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}