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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-33180152-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=33180152&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 33180152,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_003873.7",
"consequences": [
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2696A>G",
"hgvs_p": "p.Tyr899Cys",
"transcript": "NM_003873.7",
"protein_id": "NP_003864.5",
"transcript_support_level": null,
"aa_start": 899,
"aa_end": null,
"aa_length": 923,
"cds_start": 2696,
"cds_end": null,
"cds_length": 2772,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000374867.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003873.7"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2696A>G",
"hgvs_p": "p.Tyr899Cys",
"transcript": "ENST00000374867.7",
"protein_id": "ENSP00000364001.2",
"transcript_support_level": 1,
"aa_start": 899,
"aa_end": null,
"aa_length": 923,
"cds_start": 2696,
"cds_end": null,
"cds_length": 2772,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_003873.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000374867.7"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2645A>G",
"hgvs_p": "p.Tyr882Cys",
"transcript": "ENST00000395995.5",
"protein_id": "ENSP00000379317.1",
"transcript_support_level": 1,
"aa_start": 882,
"aa_end": null,
"aa_length": 906,
"cds_start": 2645,
"cds_end": null,
"cds_length": 2721,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000395995.5"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2132A>G",
"hgvs_p": "p.Tyr711Cys",
"transcript": "ENST00000374875.5",
"protein_id": "ENSP00000364009.1",
"transcript_support_level": 1,
"aa_start": 711,
"aa_end": null,
"aa_length": 735,
"cds_start": 2132,
"cds_end": null,
"cds_length": 2208,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000374875.5"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2699A>G",
"hgvs_p": "p.Tyr900Cys",
"transcript": "ENST00000897564.1",
"protein_id": "ENSP00000567623.1",
"transcript_support_level": null,
"aa_start": 900,
"aa_end": null,
"aa_length": 924,
"cds_start": 2699,
"cds_end": null,
"cds_length": 2775,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897564.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2696A>G",
"hgvs_p": "p.Tyr899Cys",
"transcript": "ENST00000265371.8",
"protein_id": "ENSP00000265371.3",
"transcript_support_level": 5,
"aa_start": 899,
"aa_end": null,
"aa_length": 923,
"cds_start": 2696,
"cds_end": null,
"cds_length": 2772,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000265371.8"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2693A>G",
"hgvs_p": "p.Tyr898Cys",
"transcript": "ENST00000949864.1",
"protein_id": "ENSP00000619923.1",
"transcript_support_level": null,
"aa_start": 898,
"aa_end": null,
"aa_length": 922,
"cds_start": 2693,
"cds_end": null,
"cds_length": 2769,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949864.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2687A>G",
"hgvs_p": "p.Tyr896Cys",
"transcript": "ENST00000949868.1",
"protein_id": "ENSP00000619927.1",
"transcript_support_level": null,
"aa_start": 896,
"aa_end": null,
"aa_length": 920,
"cds_start": 2687,
"cds_end": null,
"cds_length": 2763,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949868.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2678A>G",
"hgvs_p": "p.Tyr893Cys",
"transcript": "NM_001244972.2",
"protein_id": "NP_001231901.2",
"transcript_support_level": null,
"aa_start": 893,
"aa_end": null,
"aa_length": 917,
"cds_start": 2678,
"cds_end": null,
"cds_length": 2754,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001244972.2"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2678A>G",
"hgvs_p": "p.Tyr893Cys",
"transcript": "ENST00000897565.1",
"protein_id": "ENSP00000567624.1",
"transcript_support_level": null,
"aa_start": 893,
"aa_end": null,
"aa_length": 917,
"cds_start": 2678,
"cds_end": null,
"cds_length": 2754,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897565.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2675A>G",
"hgvs_p": "p.Tyr892Cys",
"transcript": "NM_001244973.2",
"protein_id": "NP_001231902.2",
"transcript_support_level": null,
"aa_start": 892,
"aa_end": null,
"aa_length": 916,
"cds_start": 2675,
"cds_end": null,
"cds_length": 2751,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001244973.2"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2672A>G",
"hgvs_p": "p.Tyr891Cys",
"transcript": "ENST00000949862.1",
"protein_id": "ENSP00000619921.1",
"transcript_support_level": null,
"aa_start": 891,
"aa_end": null,
"aa_length": 915,
"cds_start": 2672,
"cds_end": null,
"cds_length": 2748,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949862.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2672A>G",
"hgvs_p": "p.Tyr891Cys",
"transcript": "ENST00000949863.1",
"protein_id": "ENSP00000619922.1",
"transcript_support_level": null,
"aa_start": 891,
"aa_end": null,
"aa_length": 915,
"cds_start": 2672,
"cds_end": null,
"cds_length": 2748,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949863.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2669A>G",
"hgvs_p": "p.Tyr890Cys",
"transcript": "ENST00000949872.1",
"protein_id": "ENSP00000619931.1",
"transcript_support_level": null,
"aa_start": 890,
"aa_end": null,
"aa_length": 914,
"cds_start": 2669,
"cds_end": null,
"cds_length": 2745,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949872.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2645A>G",
"hgvs_p": "p.Tyr882Cys",
"transcript": "NM_001330068.2",
"protein_id": "NP_001316997.2",
"transcript_support_level": null,
"aa_start": 882,
"aa_end": null,
"aa_length": 906,
"cds_start": 2645,
"cds_end": null,
"cds_length": 2721,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001330068.2"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2594A>G",
"hgvs_p": "p.Tyr865Cys",
"transcript": "ENST00000949861.1",
"protein_id": "ENSP00000619920.1",
"transcript_support_level": null,
"aa_start": 865,
"aa_end": null,
"aa_length": 889,
"cds_start": 2594,
"cds_end": null,
"cds_length": 2670,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949861.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2591A>G",
"hgvs_p": "p.Tyr864Cys",
"transcript": "ENST00000897563.1",
"protein_id": "ENSP00000567622.1",
"transcript_support_level": null,
"aa_start": 864,
"aa_end": null,
"aa_length": 888,
"cds_start": 2591,
"cds_end": null,
"cds_length": 2667,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897563.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2561A>G",
"hgvs_p": "p.Tyr854Cys",
"transcript": "ENST00000949865.1",
"protein_id": "ENSP00000619924.1",
"transcript_support_level": null,
"aa_start": 854,
"aa_end": null,
"aa_length": 878,
"cds_start": 2561,
"cds_end": null,
"cds_length": 2637,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949865.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2558A>G",
"hgvs_p": "p.Tyr853Cys",
"transcript": "ENST00000949867.1",
"protein_id": "ENSP00000619926.1",
"transcript_support_level": null,
"aa_start": 853,
"aa_end": null,
"aa_length": 877,
"cds_start": 2558,
"cds_end": null,
"cds_length": 2634,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949867.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2540A>G",
"hgvs_p": "p.Tyr847Cys",
"transcript": "ENST00000949866.1",
"protein_id": "ENSP00000619925.1",
"transcript_support_level": null,
"aa_start": 847,
"aa_end": null,
"aa_length": 871,
"cds_start": 2540,
"cds_end": null,
"cds_length": 2616,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949866.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2537A>G",
"hgvs_p": "p.Tyr846Cys",
"transcript": "ENST00000949873.1",
"protein_id": "ENSP00000619932.1",
"transcript_support_level": null,
"aa_start": 846,
"aa_end": null,
"aa_length": 870,
"cds_start": 2537,
"cds_end": null,
"cds_length": 2613,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949873.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP1",
"gene_hgnc_id": 8004,
"hgvs_c": "c.2519A>G",
"hgvs_p": "p.Tyr840Cys",
"transcript": "ENST00000949869.1",
"protein_id": "ENSP00000619928.1",
"transcript_support_level": null,
"aa_start": 840,
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}
],
"message": null
}