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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-37952139-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=37952139&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 37952139,
"ref": "A",
"alt": "C",
"effect": "missense_variant",
"transcript": "ENST00000302609.8",
"consequences": [
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1359T>G",
"hgvs_p": "p.Asn453Lys",
"transcript": "NM_145011.4",
"protein_id": "NP_659448.1",
"transcript_support_level": null,
"aa_start": 453,
"aa_end": null,
"aa_length": 456,
"cds_start": 1359,
"cds_end": null,
"cds_length": 1371,
"cdna_start": 1586,
"cdna_end": null,
"cdna_length": 4152,
"mane_select": "ENST00000302609.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1359T>G",
"hgvs_p": "p.Asn453Lys",
"transcript": "ENST00000302609.8",
"protein_id": "ENSP00000302222.7",
"transcript_support_level": 1,
"aa_start": 453,
"aa_end": null,
"aa_length": 456,
"cds_start": 1359,
"cds_end": null,
"cds_length": 1371,
"cdna_start": 1586,
"cdna_end": null,
"cdna_length": 4152,
"mane_select": "NM_145011.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "n.1589T>G",
"hgvs_p": null,
"transcript": "ENST00000374633.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3161,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1371T>G",
"hgvs_p": "p.Asn457Lys",
"transcript": "NM_001329647.2",
"protein_id": "NP_001316576.1",
"transcript_support_level": null,
"aa_start": 457,
"aa_end": null,
"aa_length": 460,
"cds_start": 1371,
"cds_end": null,
"cds_length": 1383,
"cdna_start": 2084,
"cdna_end": null,
"cdna_length": 4650,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1371T>G",
"hgvs_p": "p.Asn457Lys",
"transcript": "NM_001329648.2",
"protein_id": "NP_001316577.1",
"transcript_support_level": null,
"aa_start": 457,
"aa_end": null,
"aa_length": 460,
"cds_start": 1371,
"cds_end": null,
"cds_length": 1383,
"cdna_start": 1757,
"cdna_end": null,
"cdna_length": 4323,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1371T>G",
"hgvs_p": "p.Asn457Lys",
"transcript": "NM_001329649.2",
"protein_id": "NP_001316578.1",
"transcript_support_level": null,
"aa_start": 457,
"aa_end": null,
"aa_length": 460,
"cds_start": 1371,
"cds_end": null,
"cds_length": 1383,
"cdna_start": 1650,
"cdna_end": null,
"cdna_length": 4216,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1359T>G",
"hgvs_p": "p.Asn453Lys",
"transcript": "NM_001329650.2",
"protein_id": "NP_001316579.1",
"transcript_support_level": null,
"aa_start": 453,
"aa_end": null,
"aa_length": 456,
"cds_start": 1359,
"cds_end": null,
"cds_length": 1371,
"cdna_start": 2020,
"cdna_end": null,
"cdna_length": 4586,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1359T>G",
"hgvs_p": "p.Asn453Lys",
"transcript": "NM_001329651.2",
"protein_id": "NP_001316580.1",
"transcript_support_level": null,
"aa_start": 453,
"aa_end": null,
"aa_length": 456,
"cds_start": 1359,
"cds_end": null,
"cds_length": 1371,
"cdna_start": 1693,
"cdna_end": null,
"cdna_length": 4259,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1359T>G",
"hgvs_p": "p.Asn453Lys",
"transcript": "NM_001329652.2",
"protein_id": "NP_001316581.1",
"transcript_support_level": null,
"aa_start": 453,
"aa_end": null,
"aa_length": 456,
"cds_start": 1359,
"cds_end": null,
"cds_length": 1371,
"cdna_start": 1582,
"cdna_end": null,
"cdna_length": 4148,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1359T>G",
"hgvs_p": "p.Asn453Lys",
"transcript": "NM_001329653.2",
"protein_id": "NP_001316582.1",
"transcript_support_level": null,
"aa_start": 453,
"aa_end": null,
"aa_length": 456,
"cds_start": 1359,
"cds_end": null,
"cds_length": 1371,
"cdna_start": 2127,
"cdna_end": null,
"cdna_length": 4693,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1359T>G",
"hgvs_p": "p.Asn453Lys",
"transcript": "NM_001329654.2",
"protein_id": "NP_001316583.1",
"transcript_support_level": null,
"aa_start": 453,
"aa_end": null,
"aa_length": 456,
"cds_start": 1359,
"cds_end": null,
"cds_length": 1371,
"cdna_start": 1530,
"cdna_end": null,
"cdna_length": 4096,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1356T>G",
"hgvs_p": "p.Asn452Lys",
"transcript": "NM_001329655.2",
"protein_id": "NP_001316584.1",
"transcript_support_level": null,
"aa_start": 452,
"aa_end": null,
"aa_length": 455,
"cds_start": 1356,
"cds_end": null,
"cds_length": 1368,
"cdna_start": 1583,
"cdna_end": null,
"cdna_length": 4149,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1251T>G",
"hgvs_p": "p.Asn417Lys",
"transcript": "NM_001329656.2",
"protein_id": "NP_001316585.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 420,
"cds_start": 1251,
"cds_end": null,
"cds_length": 1263,
"cdna_start": 1930,
"cdna_end": null,
"cdna_length": 4496,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1251T>G",
"hgvs_p": "p.Asn417Lys",
"transcript": "NM_001329657.2",
"protein_id": "NP_001316586.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 420,
"cds_start": 1251,
"cds_end": null,
"cds_length": 1263,
"cdna_start": 1609,
"cdna_end": null,
"cdna_length": 4175,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1251T>G",
"hgvs_p": "p.Asn417Lys",
"transcript": "NM_001329658.2",
"protein_id": "NP_001316587.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 420,
"cds_start": 1251,
"cds_end": null,
"cds_length": 1263,
"cdna_start": 1823,
"cdna_end": null,
"cdna_length": 4389,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1251T>G",
"hgvs_p": "p.Asn417Lys",
"transcript": "NM_001329659.2",
"protein_id": "NP_001316588.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 420,
"cds_start": 1251,
"cds_end": null,
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"cdna_start": 1716,
"cdna_end": null,
"cdna_length": 4282,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1251T>G",
"hgvs_p": "p.Asn417Lys",
"transcript": "NM_001329660.2",
"protein_id": "NP_001316589.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 420,
"cds_start": 1251,
"cds_end": null,
"cds_length": 1263,
"cdna_start": 1910,
"cdna_end": null,
"cdna_length": 4476,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1251T>G",
"hgvs_p": "p.Asn417Lys",
"transcript": "NM_001329661.2",
"protein_id": "NP_001316590.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 420,
"cds_start": 1251,
"cds_end": null,
"cds_length": 1263,
"cdna_start": 1780,
"cdna_end": null,
"cdna_length": 4346,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1251T>G",
"hgvs_p": "p.Asn417Lys",
"transcript": "NM_001329662.2",
"protein_id": "NP_001316591.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 420,
"cds_start": 1251,
"cds_end": null,
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"cdna_start": 2257,
"cdna_end": null,
"cdna_length": 4823,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1251T>G",
"hgvs_p": "p.Asn417Lys",
"transcript": "NM_001329663.2",
"protein_id": "NP_001316592.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 420,
"cds_start": 1251,
"cds_end": null,
"cds_length": 1263,
"cdna_start": 2043,
"cdna_end": null,
"cdna_length": 4609,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1251T>G",
"hgvs_p": "p.Asn417Lys",
"transcript": "NM_001329664.2",
"protein_id": "NP_001316593.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 420,
"cds_start": 1251,
"cds_end": null,
"cds_length": 1263,
"cdna_start": 2150,
"cdna_end": null,
"cdna_length": 4716,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "c.1251T>G",
"hgvs_p": "p.Asn417Lys",
"transcript": "XM_047424716.1",
"protein_id": "XP_047280672.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 420,
"cds_start": 1251,
"cds_end": null,
"cds_length": 1263,
"cdna_start": 2280,
"cdna_end": null,
"cdna_length": 4846,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF25",
"gene_hgnc_id": 13043,
"hgvs_c": "n.1728T>G",
"hgvs_p": null,
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}