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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-45625975-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=45625975&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"message": null,
"variants": [
{
"acmg_by_gene": [
{
"benign_score": 5,
"criteria": [
"PM2",
"BP4_Strong",
"BP7"
],
"effects": [
"synonymous_variant"
],
"gene_symbol": "ZFAND4",
"hgnc_id": 23504,
"hgvs_c": "c.1848G>A",
"hgvs_p": "p.Gln616Gln",
"inheritance_mode": "AR",
"pathogenic_score": 2,
"score": -3,
"transcript": "NM_174890.4",
"verdict": "Likely_benign"
}
],
"acmg_classification": "Likely_benign",
"acmg_criteria": "PM2,BP4_Strong,BP7",
"acmg_score": -3,
"allele_count_reference_population": 1,
"alphamissense_prediction": null,
"alphamissense_score": null,
"alt": "T",
"apogee2_prediction": null,
"apogee2_score": null,
"bayesdelnoaf_prediction": "Benign",
"bayesdelnoaf_score": -0.8,
"chr": "10",
"clinvar_classification": "",
"clinvar_disease": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"computational_prediction_selected": "Benign",
"computational_score_selected": -0.800000011920929,
"computational_source_selected": "BayesDel_noAF",
"consequences": [
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 727,
"aa_ref": "Q",
"aa_start": 616,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3760,
"cdna_start": 2488,
"cds_end": null,
"cds_length": 2184,
"cds_start": 1848,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "NM_174890.4",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1848G>A",
"hgvs_p": "p.Gln616Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "ENST00000344646.10",
"protein_coding": true,
"protein_id": "NP_777550.2",
"strand": false,
"transcript": "NM_174890.4",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 727,
"aa_ref": "Q",
"aa_start": 616,
"biotype": "protein_coding",
"canonical": true,
"cdna_end": null,
"cdna_length": 3760,
"cdna_start": 2488,
"cds_end": null,
"cds_length": 2184,
"cds_start": 1848,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000344646.10",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1848G>A",
"hgvs_p": "p.Gln616Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "NM_174890.4",
"protein_coding": true,
"protein_id": "ENSP00000339484.5",
"strand": false,
"transcript": "ENST00000344646.10",
"transcript_support_level": 1
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 653,
"aa_ref": "Q",
"aa_start": 542,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3821,
"cdna_start": 2550,
"cds_end": null,
"cds_length": 1962,
"cds_start": 1626,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000374366.7",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1626G>A",
"hgvs_p": "p.Gln542Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000363486.3",
"strand": false,
"transcript": "ENST00000374366.7",
"transcript_support_level": 1
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 733,
"aa_ref": "Q",
"aa_start": 622,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3690,
"cdna_start": 2515,
"cds_end": null,
"cds_length": 2202,
"cds_start": 1866,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000947494.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1866G>A",
"hgvs_p": "p.Gln622Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000617553.1",
"strand": false,
"transcript": "ENST00000947494.1",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 727,
"aa_ref": "Q",
"aa_start": 616,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3371,
"cdna_start": 2100,
"cds_end": null,
"cds_length": 2184,
"cds_start": 1848,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "NM_001128324.2",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1848G>A",
"hgvs_p": "p.Gln616Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001121796.1",
"strand": false,
"transcript": "NM_001128324.2",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 727,
"aa_ref": "Q",
"aa_start": 616,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3676,
"cdna_start": 2497,
"cds_end": null,
"cds_length": 2184,
"cds_start": 1848,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000907319.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1848G>A",
"hgvs_p": "p.Gln616Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000577378.1",
"strand": false,
"transcript": "ENST00000907319.1",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 727,
"aa_ref": "Q",
"aa_start": 616,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3266,
"cdna_start": 2088,
"cds_end": null,
"cds_length": 2184,
"cds_start": 1848,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000907320.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1848G>A",
"hgvs_p": "p.Gln616Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000577379.1",
"strand": false,
"transcript": "ENST00000907320.1",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 727,
"aa_ref": "Q",
"aa_start": 616,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3599,
"cdna_start": 2559,
"cds_end": null,
"cds_length": 2184,
"cds_start": 1848,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000907323.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1848G>A",
"hgvs_p": "p.Gln616Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000577382.1",
"strand": false,
"transcript": "ENST00000907323.1",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 727,
"aa_ref": "Q",
"aa_start": 616,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4596,
"cdna_start": 2395,
"cds_end": null,
"cds_length": 2184,
"cds_start": 1848,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000940116.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1848G>A",
"hgvs_p": "p.Gln616Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000610175.1",
"strand": false,
"transcript": "ENST00000940116.1",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 727,
"aa_ref": "Q",
"aa_start": 616,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3371,
"cdna_start": 2197,
"cds_end": null,
"cds_length": 2184,
"cds_start": 1848,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000940117.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1848G>A",
"hgvs_p": "p.Gln616Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000610176.1",
"strand": false,
"transcript": "ENST00000940117.1",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 679,
"aa_ref": "Q",
"aa_start": 568,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3523,
"cdna_start": 2342,
"cds_end": null,
"cds_length": 2040,
"cds_start": 1704,
"consequences": [
"synonymous_variant"
],
"exon_count": 8,
"exon_rank": 5,
"exon_rank_end": null,
"feature": "ENST00000907321.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1704G>A",
"hgvs_p": "p.Gln568Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000577380.1",
"strand": false,
"transcript": "ENST00000907321.1",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 679,
"aa_ref": "Q",
"aa_start": 568,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3521,
"cdna_start": 2344,
"cds_end": null,
"cds_length": 2040,
"cds_start": 1704,
"consequences": [
"synonymous_variant"
],
"exon_count": 8,
"exon_rank": 5,
"exon_rank_end": null,
"feature": "ENST00000907322.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1704G>A",
"hgvs_p": "p.Gln568Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000577381.1",
"strand": false,
"transcript": "ENST00000907322.1",
"transcript_support_level": null
},
{
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"aa_ref": "Q",
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"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 5332,
"cdna_start": 1935,
"cds_end": null,
"cds_length": 2040,
"cds_start": 1704,
"consequences": [
"synonymous_variant"
],
"exon_count": 8,
"exon_rank": 5,
"exon_rank_end": null,
"feature": "ENST00000940115.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1704G>A",
"hgvs_p": "p.Gln568Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000610174.1",
"strand": false,
"transcript": "ENST00000940115.1",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 679,
"aa_ref": "Q",
"aa_start": 568,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3274,
"cdna_start": 2100,
"cds_end": null,
"cds_length": 2040,
"cds_start": 1704,
"consequences": [
"synonymous_variant"
],
"exon_count": 8,
"exon_rank": 5,
"exon_rank_end": null,
"feature": "ENST00000940118.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1704G>A",
"hgvs_p": "p.Gln568Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000610177.1",
"strand": false,
"transcript": "ENST00000940118.1",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 679,
"aa_ref": "Q",
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"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3188,
"cdna_start": 2015,
"cds_end": null,
"cds_length": 2040,
"cds_start": 1704,
"consequences": [
"synonymous_variant"
],
"exon_count": 8,
"exon_rank": 5,
"exon_rank_end": null,
"feature": "ENST00000940119.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1704G>A",
"hgvs_p": "p.Gln568Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000610178.1",
"strand": false,
"transcript": "ENST00000940119.1",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 653,
"aa_ref": "Q",
"aa_start": 542,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3821,
"cdna_start": 2550,
"cds_end": null,
"cds_length": 1962,
"cds_start": 1626,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "NM_001282905.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1626G>A",
"hgvs_p": "p.Gln542Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001269834.1",
"strand": false,
"transcript": "NM_001282905.1",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 653,
"aa_ref": "Q",
"aa_start": 542,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3473,
"cdna_start": 2202,
"cds_end": null,
"cds_length": 1962,
"cds_start": 1626,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "NM_001282906.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1626G>A",
"hgvs_p": "p.Gln542Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001269835.1",
"strand": false,
"transcript": "NM_001282906.1",
"transcript_support_level": null
},
{
"aa_alt": "Q",
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"aa_ref": "Q",
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"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4016,
"cdna_start": 2744,
"cds_end": null,
"cds_length": 2370,
"cds_start": 2034,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "XM_047426008.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.2034G>A",
"hgvs_p": "p.Gln678Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "XP_047281964.1",
"strand": false,
"transcript": "XM_047426008.1",
"transcript_support_level": null
},
{
"aa_alt": "Q",
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"aa_ref": "Q",
"aa_start": 672,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3998,
"cdna_start": 2726,
"cds_end": null,
"cds_length": 2352,
"cds_start": 2016,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "XM_047426009.1",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.2016G>A",
"hgvs_p": "p.Gln672Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "XP_047281965.1",
"strand": false,
"transcript": "XM_047426009.1",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 741,
"aa_ref": "Q",
"aa_start": 630,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3335,
"cdna_start": 2063,
"cds_end": null,
"cds_length": 2226,
"cds_start": 1890,
"consequences": [
"synonymous_variant"
],
"exon_count": 8,
"exon_rank": 5,
"exon_rank_end": null,
"feature": "XM_017016931.2",
"gene_hgnc_id": 23504,
"gene_symbol": "ZFAND4",
"hgvs_c": "c.1890G>A",
"hgvs_p": "p.Gln630Gln",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "XP_016872420.1",
"strand": false,
"transcript": "XM_017016931.2",
"transcript_support_level": null
},
{
"aa_alt": "Q",
"aa_end": null,
"aa_length": 735,
"aa_ref": "Q",
"aa_start": 624,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3854,
"cdna_start": 2582,
"cds_end": null,
"cds_length": 2208,
"cds_start": 1872,
"consequences": [
"synonymous_variant"
],
"exon_count": 8,
"exon_rank": 5,
"exon_rank_end": null,
"feature": "XM_011540366.3",
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