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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-45652878-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=45652878&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 45652878,
"ref": "T",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000344646.10",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZFAND4",
"gene_hgnc_id": 23504,
"hgvs_c": "c.260+106A>C",
"hgvs_p": null,
"transcript": "NM_174890.4",
"protein_id": "NP_777550.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 727,
"cds_start": -4,
"cds_end": null,
"cds_length": 2184,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3760,
"mane_select": "ENST00000344646.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZFAND4",
"gene_hgnc_id": 23504,
"hgvs_c": "c.260+106A>C",
"hgvs_p": null,
"transcript": "ENST00000344646.10",
"protein_id": "ENSP00000339484.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 727,
"cds_start": -4,
"cds_end": null,
"cds_length": 2184,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3760,
"mane_select": "NM_174890.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZFAND4",
"gene_hgnc_id": 23504,
"hgvs_c": "c.38+106A>C",
"hgvs_p": null,
"transcript": "ENST00000374366.7",
"protein_id": "ENSP00000363486.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 653,
"cds_start": -4,
"cds_end": null,
"cds_length": 1962,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3821,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZFAND4",
"gene_hgnc_id": 23504,
"hgvs_c": "c.260+106A>C",
"hgvs_p": null,
"transcript": "NM_001128324.2",
"protein_id": "NP_001121796.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 727,
"cds_start": -4,
"cds_end": null,
"cds_length": 2184,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3371,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZFAND4",
"gene_hgnc_id": 23504,
"hgvs_c": "c.38+106A>C",
"hgvs_p": null,
"transcript": "NM_001282905.1",
"protein_id": "NP_001269834.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 653,
"cds_start": -4,
"cds_end": null,
"cds_length": 1962,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3821,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZFAND4",
"gene_hgnc_id": 23504,
"hgvs_c": "c.38+106A>C",
"hgvs_p": null,
"transcript": "NM_001282906.1",
"protein_id": "NP_001269835.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 653,
"cds_start": -4,
"cds_end": null,
"cds_length": 1962,
"cdna_start": null,
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"cdna_length": 3473,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZFAND4",
"gene_hgnc_id": 23504,
"hgvs_c": "c.260+106A>C",
"hgvs_p": null,
"transcript": "ENST00000374371.6",
"protein_id": "ENSP00000363491.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 224,
"cds_start": -4,
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"cds_length": 675,
"cdna_start": null,
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"cdna_length": 2283,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZFAND4",
"gene_hgnc_id": 23504,
"hgvs_c": "n.479+106A>C",
"hgvs_p": null,
"transcript": "ENST00000335258.8",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2048,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZFAND4",
"gene_hgnc_id": 23504,
"hgvs_c": "n.260+106A>C",
"hgvs_p": null,
"transcript": "ENST00000465407.5",
"protein_id": "ENSP00000434854.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 1209,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 4,
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"gene_symbol": "ZFAND4",
"gene_hgnc_id": 23504,
"hgvs_c": "n.*80+106A>C",
"hgvs_p": null,
"transcript": "ENST00000495747.5",
"protein_id": "ENSP00000477595.1",
"transcript_support_level": 5,
"aa_start": null,
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 2,
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"gene_symbol": "ZFAND4",
"gene_hgnc_id": 23504,
"hgvs_c": "n.793-845A>C",
"hgvs_p": null,
"transcript": "ENST00000497028.5",
"protein_id": null,
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},
{
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],
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},
{
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],
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"gene_symbol": "ZFAND4",
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"protein_id": "XP_047281964.1",
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],
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"gene_symbol": "ZFAND4",
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],
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},
{
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],
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"gene_symbol": "ZFAND4",
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"transcript": "XM_011540366.3",
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],
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"transcript": "XM_017016933.3",
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},
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],
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"gene_symbol": "ZFAND4",
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"hgvs_c": "c.260+106A>C",
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"transcript": "XM_047426010.1",
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},
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],
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"intron_rank": 4,
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"gene_symbol": "ZFAND4",
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],
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"gene_symbol": "ZFAND4",
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"hgvs_c": "c.428+106A>C",
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"transcript": "XM_017016935.2",
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},
{
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],
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"exon_count": 8,
"intron_rank": 3,
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"gene_symbol": "ZFAND4",
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"hgvs_c": "c.428+106A>C",
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"transcript": "XM_047426013.1",
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}
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}