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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-48446578-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=48446578&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 48446578,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001256024.2",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1910G>T",
"hgvs_p": "p.Arg637Leu",
"transcript": "NM_021226.4",
"protein_id": "NP_067049.2",
"transcript_support_level": null,
"aa_start": 637,
"aa_end": null,
"aa_length": 698,
"cds_start": 1910,
"cds_end": null,
"cds_length": 2097,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000249601.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_021226.4"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1910G>T",
"hgvs_p": "p.Arg637Leu",
"transcript": "ENST00000249601.9",
"protein_id": "ENSP00000249601.4",
"transcript_support_level": 1,
"aa_start": 637,
"aa_end": null,
"aa_length": 698,
"cds_start": 1910,
"cds_end": null,
"cds_length": 2097,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_021226.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000249601.9"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1958G>T",
"hgvs_p": "p.Arg653Leu",
"transcript": "ENST00000417912.6",
"protein_id": "ENSP00000412461.2",
"transcript_support_level": 1,
"aa_start": 653,
"aa_end": null,
"aa_length": 714,
"cds_start": 1958,
"cds_end": null,
"cds_length": 2145,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000417912.6"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1409G>T",
"hgvs_p": "p.Arg470Leu",
"transcript": "ENST00000477708.6",
"protein_id": "ENSP00000422868.1",
"transcript_support_level": 1,
"aa_start": 470,
"aa_end": null,
"aa_length": 531,
"cds_start": 1409,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000477708.6"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1958G>T",
"hgvs_p": "p.Arg653Leu",
"transcript": "NM_001256024.2",
"protein_id": "NP_001242953.1",
"transcript_support_level": null,
"aa_start": 653,
"aa_end": null,
"aa_length": 714,
"cds_start": 1958,
"cds_end": null,
"cds_length": 2145,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001256024.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1928G>T",
"hgvs_p": "p.Arg643Leu",
"transcript": "NM_001256025.3",
"protein_id": "NP_001242954.1",
"transcript_support_level": null,
"aa_start": 643,
"aa_end": null,
"aa_length": 704,
"cds_start": 1928,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001256025.3"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1928G>T",
"hgvs_p": "p.Arg643Leu",
"transcript": "NM_001347738.2",
"protein_id": "NP_001334667.1",
"transcript_support_level": null,
"aa_start": 643,
"aa_end": null,
"aa_length": 704,
"cds_start": 1928,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001347738.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1928G>T",
"hgvs_p": "p.Arg643Leu",
"transcript": "ENST00000435790.6",
"protein_id": "ENSP00000416701.2",
"transcript_support_level": 2,
"aa_start": 643,
"aa_end": null,
"aa_length": 704,
"cds_start": 1928,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000435790.6"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1781G>T",
"hgvs_p": "p.Arg594Leu",
"transcript": "NM_001347735.2",
"protein_id": "NP_001334664.1",
"transcript_support_level": null,
"aa_start": 594,
"aa_end": null,
"aa_length": 655,
"cds_start": 1781,
"cds_end": null,
"cds_length": 1968,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001347735.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1781G>T",
"hgvs_p": "p.Arg594Leu",
"transcript": "ENST00000868871.1",
"protein_id": "ENSP00000538930.1",
"transcript_support_level": null,
"aa_start": 594,
"aa_end": null,
"aa_length": 655,
"cds_start": 1781,
"cds_end": null,
"cds_length": 1968,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868871.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1703G>T",
"hgvs_p": "p.Arg568Leu",
"transcript": "ENST00000968938.1",
"protein_id": "ENSP00000638997.1",
"transcript_support_level": null,
"aa_start": 568,
"aa_end": null,
"aa_length": 629,
"cds_start": 1703,
"cds_end": null,
"cds_length": 1890,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968938.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1640G>T",
"hgvs_p": "p.Arg547Leu",
"transcript": "NM_001256026.2",
"protein_id": "NP_001242955.1",
"transcript_support_level": null,
"aa_start": 547,
"aa_end": null,
"aa_length": 608,
"cds_start": 1640,
"cds_end": null,
"cds_length": 1827,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001256026.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1640G>T",
"hgvs_p": "p.Arg547Leu",
"transcript": "ENST00000417247.6",
"protein_id": "ENSP00000410054.2",
"transcript_support_level": 2,
"aa_start": 547,
"aa_end": null,
"aa_length": 608,
"cds_start": 1640,
"cds_end": null,
"cds_length": 1827,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000417247.6"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1583G>T",
"hgvs_p": "p.Arg528Leu",
"transcript": "ENST00000374172.5",
"protein_id": "ENSP00000363287.1",
"transcript_support_level": 2,
"aa_start": 528,
"aa_end": null,
"aa_length": 589,
"cds_start": 1583,
"cds_end": null,
"cds_length": 1770,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000374172.5"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1433G>T",
"hgvs_p": "p.Arg478Leu",
"transcript": "ENST00000374170.5",
"protein_id": "ENSP00000363285.1",
"transcript_support_level": 5,
"aa_start": 478,
"aa_end": null,
"aa_length": 539,
"cds_start": 1433,
"cds_end": null,
"cds_length": 1620,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000374170.5"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1976G>T",
"hgvs_p": "p.Arg659Leu",
"transcript": "XM_011540002.3",
"protein_id": "XP_011538304.1",
"transcript_support_level": null,
"aa_start": 659,
"aa_end": null,
"aa_length": 720,
"cds_start": 1976,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011540002.3"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1976G>T",
"hgvs_p": "p.Arg659Leu",
"transcript": "XM_011540003.2",
"protein_id": "XP_011538305.1",
"transcript_support_level": null,
"aa_start": 659,
"aa_end": null,
"aa_length": 720,
"cds_start": 1976,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011540003.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1976G>T",
"hgvs_p": "p.Arg659Leu",
"transcript": "XM_024448099.2",
"protein_id": "XP_024303867.1",
"transcript_support_level": null,
"aa_start": 659,
"aa_end": null,
"aa_length": 720,
"cds_start": 1976,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024448099.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1928G>T",
"hgvs_p": "p.Arg643Leu",
"transcript": "XM_047425586.1",
"protein_id": "XP_047281542.1",
"transcript_support_level": null,
"aa_start": 643,
"aa_end": null,
"aa_length": 704,
"cds_start": 1928,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047425586.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1925G>T",
"hgvs_p": "p.Arg642Leu",
"transcript": "XM_047425587.1",
"protein_id": "XP_047281543.1",
"transcript_support_level": null,
"aa_start": 642,
"aa_end": null,
"aa_length": 703,
"cds_start": 1925,
"cds_end": null,
"cds_length": 2112,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047425587.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1799G>T",
"hgvs_p": "p.Arg600Leu",
"transcript": "XM_011540006.3",
"protein_id": "XP_011538308.1",
"transcript_support_level": null,
"aa_start": 600,
"aa_end": null,
"aa_length": 661,
"cds_start": 1799,
"cds_end": null,
"cds_length": 1986,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011540006.3"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1688G>T",
"hgvs_p": "p.Arg563Leu",
"transcript": "XM_005270014.4",
"protein_id": "XP_005270071.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 624,
"cds_start": 1688,
"cds_end": null,
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