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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-48450411-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=48450411&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 48450411,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001256024.2",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1718C>T",
"hgvs_p": "p.Ala573Val",
"transcript": "NM_021226.4",
"protein_id": "NP_067049.2",
"transcript_support_level": null,
"aa_start": 573,
"aa_end": null,
"aa_length": 698,
"cds_start": 1718,
"cds_end": null,
"cds_length": 2097,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000249601.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_021226.4"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1718C>T",
"hgvs_p": "p.Ala573Val",
"transcript": "ENST00000249601.9",
"protein_id": "ENSP00000249601.4",
"transcript_support_level": 1,
"aa_start": 573,
"aa_end": null,
"aa_length": 698,
"cds_start": 1718,
"cds_end": null,
"cds_length": 2097,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_021226.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000249601.9"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1766C>T",
"hgvs_p": "p.Ala589Val",
"transcript": "ENST00000417912.6",
"protein_id": "ENSP00000412461.2",
"transcript_support_level": 1,
"aa_start": 589,
"aa_end": null,
"aa_length": 714,
"cds_start": 1766,
"cds_end": null,
"cds_length": 2145,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000417912.6"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1217C>T",
"hgvs_p": "p.Ala406Val",
"transcript": "ENST00000477708.6",
"protein_id": "ENSP00000422868.1",
"transcript_support_level": 1,
"aa_start": 406,
"aa_end": null,
"aa_length": 531,
"cds_start": 1217,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000477708.6"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1766C>T",
"hgvs_p": "p.Ala589Val",
"transcript": "NM_001256024.2",
"protein_id": "NP_001242953.1",
"transcript_support_level": null,
"aa_start": 589,
"aa_end": null,
"aa_length": 714,
"cds_start": 1766,
"cds_end": null,
"cds_length": 2145,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001256024.2"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1736C>T",
"hgvs_p": "p.Ala579Val",
"transcript": "NM_001256025.3",
"protein_id": "NP_001242954.1",
"transcript_support_level": null,
"aa_start": 579,
"aa_end": null,
"aa_length": 704,
"cds_start": 1736,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001256025.3"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1736C>T",
"hgvs_p": "p.Ala579Val",
"transcript": "NM_001347738.2",
"protein_id": "NP_001334667.1",
"transcript_support_level": null,
"aa_start": 579,
"aa_end": null,
"aa_length": 704,
"cds_start": 1736,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001347738.2"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1736C>T",
"hgvs_p": "p.Ala579Val",
"transcript": "ENST00000435790.6",
"protein_id": "ENSP00000416701.2",
"transcript_support_level": 2,
"aa_start": 579,
"aa_end": null,
"aa_length": 704,
"cds_start": 1736,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000435790.6"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1589C>T",
"hgvs_p": "p.Ala530Val",
"transcript": "NM_001347735.2",
"protein_id": "NP_001334664.1",
"transcript_support_level": null,
"aa_start": 530,
"aa_end": null,
"aa_length": 655,
"cds_start": 1589,
"cds_end": null,
"cds_length": 1968,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001347735.2"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1589C>T",
"hgvs_p": "p.Ala530Val",
"transcript": "ENST00000868871.1",
"protein_id": "ENSP00000538930.1",
"transcript_support_level": null,
"aa_start": 530,
"aa_end": null,
"aa_length": 655,
"cds_start": 1589,
"cds_end": null,
"cds_length": 1968,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868871.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1511C>T",
"hgvs_p": "p.Ala504Val",
"transcript": "ENST00000968938.1",
"protein_id": "ENSP00000638997.1",
"transcript_support_level": null,
"aa_start": 504,
"aa_end": null,
"aa_length": 629,
"cds_start": 1511,
"cds_end": null,
"cds_length": 1890,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968938.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1448C>T",
"hgvs_p": "p.Ala483Val",
"transcript": "NM_001256026.2",
"protein_id": "NP_001242955.1",
"transcript_support_level": null,
"aa_start": 483,
"aa_end": null,
"aa_length": 608,
"cds_start": 1448,
"cds_end": null,
"cds_length": 1827,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001256026.2"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1448C>T",
"hgvs_p": "p.Ala483Val",
"transcript": "ENST00000417247.6",
"protein_id": "ENSP00000410054.2",
"transcript_support_level": 2,
"aa_start": 483,
"aa_end": null,
"aa_length": 608,
"cds_start": 1448,
"cds_end": null,
"cds_length": 1827,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000417247.6"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1391C>T",
"hgvs_p": "p.Ala464Val",
"transcript": "ENST00000374172.5",
"protein_id": "ENSP00000363287.1",
"transcript_support_level": 2,
"aa_start": 464,
"aa_end": null,
"aa_length": 589,
"cds_start": 1391,
"cds_end": null,
"cds_length": 1770,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000374172.5"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1241C>T",
"hgvs_p": "p.Ala414Val",
"transcript": "ENST00000374170.5",
"protein_id": "ENSP00000363285.1",
"transcript_support_level": 5,
"aa_start": 414,
"aa_end": null,
"aa_length": 539,
"cds_start": 1241,
"cds_end": null,
"cds_length": 1620,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000374170.5"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1784C>T",
"hgvs_p": "p.Ala595Val",
"transcript": "XM_011540002.3",
"protein_id": "XP_011538304.1",
"transcript_support_level": null,
"aa_start": 595,
"aa_end": null,
"aa_length": 720,
"cds_start": 1784,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011540002.3"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1784C>T",
"hgvs_p": "p.Ala595Val",
"transcript": "XM_011540003.2",
"protein_id": "XP_011538305.1",
"transcript_support_level": null,
"aa_start": 595,
"aa_end": null,
"aa_length": 720,
"cds_start": 1784,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011540003.2"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1784C>T",
"hgvs_p": "p.Ala595Val",
"transcript": "XM_024448099.2",
"protein_id": "XP_024303867.1",
"transcript_support_level": null,
"aa_start": 595,
"aa_end": null,
"aa_length": 720,
"cds_start": 1784,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024448099.2"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1736C>T",
"hgvs_p": "p.Ala579Val",
"transcript": "XM_047425586.1",
"protein_id": "XP_047281542.1",
"transcript_support_level": null,
"aa_start": 579,
"aa_end": null,
"aa_length": 704,
"cds_start": 1736,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047425586.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Ala578Val",
"transcript": "XM_047425587.1",
"protein_id": "XP_047281543.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 703,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2112,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047425587.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1607C>T",
"hgvs_p": "p.Ala536Val",
"transcript": "XM_011540006.3",
"protein_id": "XP_011538308.1",
"transcript_support_level": null,
"aa_start": 536,
"aa_end": null,
"aa_length": 661,
"cds_start": 1607,
"cds_end": null,
"cds_length": 1986,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011540006.3"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.1496C>T",
"hgvs_p": "p.Ala499Val",
"transcript": "XM_005270014.4",
"protein_id": "XP_005270071.1",
"transcript_support_level": null,
"aa_start": 499,
"aa_end": null,
"aa_length": 624,
"cds_start": 1496,
"cds_end": null,
"cds_length": 1875,
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