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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-48602322-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=48602322&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 48602322,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000249601.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.34+2441C>T",
"hgvs_p": null,
"transcript": "NM_021226.4",
"protein_id": "NP_067049.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 698,
"cds_start": -4,
"cds_end": null,
"cds_length": 2097,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2729,
"mane_select": "ENST00000249601.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.34+2441C>T",
"hgvs_p": null,
"transcript": "ENST00000249601.9",
"protein_id": "ENSP00000249601.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 698,
"cds_start": -4,
"cds_end": null,
"cds_length": 2097,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2729,
"mane_select": "NM_021226.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.34+2441C>T",
"hgvs_p": null,
"transcript": "ENST00000417912.6",
"protein_id": "ENSP00000412461.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 714,
"cds_start": -4,
"cds_end": null,
"cds_length": 2145,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2352,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.34+2441C>T",
"hgvs_p": null,
"transcript": "NM_001256024.2",
"protein_id": "NP_001242953.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 714,
"cds_start": -4,
"cds_end": null,
"cds_length": 2145,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2777,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.53-19170C>T",
"hgvs_p": null,
"transcript": "NM_001256025.3",
"protein_id": "NP_001242954.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 704,
"cds_start": -4,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2687,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.53-19170C>T",
"hgvs_p": null,
"transcript": "NM_001347738.2",
"protein_id": "NP_001334667.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 704,
"cds_start": -4,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2822,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.53-19170C>T",
"hgvs_p": null,
"transcript": "ENST00000435790.6",
"protein_id": "ENSP00000416701.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 704,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 2595,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.34+2441C>T",
"hgvs_p": null,
"transcript": "NM_001347735.2",
"protein_id": "NP_001334664.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 655,
"cds_start": -4,
"cds_end": null,
"cds_length": 1968,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2600,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.53-19170C>T",
"hgvs_p": null,
"transcript": "NM_001347736.2",
"protein_id": "NP_001334665.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 87,
"cds_start": -4,
"cds_end": null,
"cds_length": 264,
"cdna_start": null,
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"cdna_length": 2028,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 3,
"intron_rank": 1,
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"gene_symbol": "ARHGAP22",
"gene_hgnc_id": 30320,
"hgvs_c": "c.34+2441C>T",
"hgvs_p": null,
"transcript": "NM_001347737.2",
"protein_id": "NP_001334666.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 2,
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"gene_symbol": "ARHGAP22",
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"hgvs_c": "n.53-19170C>T",
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"transcript": "ENST00000460425.1",
"protein_id": "ENSP00000422663.1",
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},
{
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],
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"transcript": "ENST00000464445.1",
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},
{
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],
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"gene_symbol": "ARHGAP22",
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"hgvs_c": "n.326+2441C>T",
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"transcript": "ENST00000471013.5",
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},
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],
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"gene_symbol": "ARHGAP22",
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"hgvs_c": "n.193+2441C>T",
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],
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},
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],
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"gene_symbol": "ARHGAP22",
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],
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},
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"gene_symbol": "ARHGAP22",
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],
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},
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"consequences": [
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],
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"intron_rank": 1,
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"gene_symbol": "ARHGAP22",
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"hgvs_c": "c.53-19170C>T",
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},
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