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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 10-49737844-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=49737844&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "10",
      "pos": 49737844,
      "ref": "T",
      "alt": "C",
      "effect": "synonymous_variant",
      "transcript": "NM_018245.3",
      "consequences": [
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2532A>G",
          "hgvs_p": "p.Thr844Thr",
          "transcript": "NM_018245.3",
          "protein_id": "NP_060715.2",
          "transcript_support_level": null,
          "aa_start": 844,
          "aa_end": null,
          "aa_length": 1010,
          "cds_start": 2532,
          "cds_end": null,
          "cds_length": 3033,
          "cdna_start": 2618,
          "cdna_end": null,
          "cdna_length": 3706,
          "mane_select": "ENST00000374103.9",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_018245.3"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2532A>G",
          "hgvs_p": "p.Thr844Thr",
          "transcript": "ENST00000374103.9",
          "protein_id": "ENSP00000363216.4",
          "transcript_support_level": 1,
          "aa_start": 844,
          "aa_end": null,
          "aa_length": 1010,
          "cds_start": 2532,
          "cds_end": null,
          "cds_length": 3033,
          "cdna_start": 2618,
          "cdna_end": null,
          "cdna_length": 3706,
          "mane_select": "NM_018245.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000374103.9"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2625A>G",
          "hgvs_p": "p.Thr875Thr",
          "transcript": "ENST00000852721.1",
          "protein_id": "ENSP00000522780.1",
          "transcript_support_level": null,
          "aa_start": 875,
          "aa_end": null,
          "aa_length": 1041,
          "cds_start": 2625,
          "cds_end": null,
          "cds_length": 3126,
          "cdna_start": 2687,
          "cdna_end": null,
          "cdna_length": 3774,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000852721.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2550A>G",
          "hgvs_p": "p.Thr850Thr",
          "transcript": "ENST00000852716.1",
          "protein_id": "ENSP00000522775.1",
          "transcript_support_level": null,
          "aa_start": 850,
          "aa_end": null,
          "aa_length": 1016,
          "cds_start": 2550,
          "cds_end": null,
          "cds_length": 3051,
          "cdna_start": 2660,
          "cdna_end": null,
          "cdna_length": 3748,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000852716.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2535A>G",
          "hgvs_p": "p.Thr845Thr",
          "transcript": "ENST00000852718.1",
          "protein_id": "ENSP00000522777.1",
          "transcript_support_level": null,
          "aa_start": 845,
          "aa_end": null,
          "aa_length": 1011,
          "cds_start": 2535,
          "cds_end": null,
          "cds_length": 3036,
          "cdna_start": 2641,
          "cdna_end": null,
          "cdna_length": 3728,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000852718.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2532A>G",
          "hgvs_p": "p.Thr844Thr",
          "transcript": "NM_001347819.1",
          "protein_id": "NP_001334748.1",
          "transcript_support_level": null,
          "aa_start": 844,
          "aa_end": null,
          "aa_length": 1010,
          "cds_start": 2532,
          "cds_end": null,
          "cds_length": 3033,
          "cdna_start": 2564,
          "cdna_end": null,
          "cdna_length": 3652,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001347819.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2532A>G",
          "hgvs_p": "p.Thr844Thr",
          "transcript": "ENST00000852713.1",
          "protein_id": "ENSP00000522772.1",
          "transcript_support_level": null,
          "aa_start": 844,
          "aa_end": null,
          "aa_length": 1010,
          "cds_start": 2532,
          "cds_end": null,
          "cds_length": 3033,
          "cdna_start": 2593,
          "cdna_end": null,
          "cdna_length": 3680,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000852713.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2532A>G",
          "hgvs_p": "p.Thr844Thr",
          "transcript": "ENST00000852720.1",
          "protein_id": "ENSP00000522779.1",
          "transcript_support_level": null,
          "aa_start": 844,
          "aa_end": null,
          "aa_length": 1010,
          "cds_start": 2532,
          "cds_end": null,
          "cds_length": 3033,
          "cdna_start": 2864,
          "cdna_end": null,
          "cdna_length": 3952,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000852720.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2532A>G",
          "hgvs_p": "p.Thr844Thr",
          "transcript": "ENST00000967765.1",
          "protein_id": "ENSP00000637824.1",
          "transcript_support_level": null,
          "aa_start": 844,
          "aa_end": null,
          "aa_length": 1010,
          "cds_start": 2532,
          "cds_end": null,
          "cds_length": 3033,
          "cdna_start": 2663,
          "cdna_end": null,
          "cdna_length": 3748,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000967765.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2526A>G",
          "hgvs_p": "p.Thr842Thr",
          "transcript": "ENST00000852722.1",
          "protein_id": "ENSP00000522781.1",
          "transcript_support_level": null,
          "aa_start": 842,
          "aa_end": null,
          "aa_length": 1008,
          "cds_start": 2526,
          "cds_end": null,
          "cds_length": 3027,
          "cdna_start": 2527,
          "cdna_end": null,
          "cdna_length": 3610,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000852722.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2508A>G",
          "hgvs_p": "p.Thr836Thr",
          "transcript": "ENST00000917749.1",
          "protein_id": "ENSP00000587808.1",
          "transcript_support_level": null,
          "aa_start": 836,
          "aa_end": null,
          "aa_length": 1002,
          "cds_start": 2508,
          "cds_end": null,
          "cds_length": 3009,
          "cdna_start": 2592,
          "cdna_end": null,
          "cdna_length": 3678,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000917749.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2532A>G",
          "hgvs_p": "p.Thr844Thr",
          "transcript": "ENST00000852717.1",
          "protein_id": "ENSP00000522776.1",
          "transcript_support_level": null,
          "aa_start": 844,
          "aa_end": null,
          "aa_length": 999,
          "cds_start": 2532,
          "cds_end": null,
          "cds_length": 3000,
          "cdna_start": 2643,
          "cdna_end": null,
          "cdna_length": 3697,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000852717.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2487A>G",
          "hgvs_p": "p.Thr829Thr",
          "transcript": "ENST00000852719.1",
          "protein_id": "ENSP00000522778.1",
          "transcript_support_level": null,
          "aa_start": 829,
          "aa_end": null,
          "aa_length": 995,
          "cds_start": 2487,
          "cds_end": null,
          "cds_length": 2988,
          "cdna_start": 2593,
          "cdna_end": null,
          "cdna_length": 3674,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000852719.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2364A>G",
          "hgvs_p": "p.Thr788Thr",
          "transcript": "ENST00000967764.1",
          "protein_id": "ENSP00000637823.1",
          "transcript_support_level": null,
          "aa_start": 788,
          "aa_end": null,
          "aa_length": 954,
          "cds_start": 2364,
          "cds_end": null,
          "cds_length": 2865,
          "cdna_start": 2391,
          "cdna_end": null,
          "cdna_length": 3476,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000967764.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2361A>G",
          "hgvs_p": "p.Thr787Thr",
          "transcript": "NM_001143996.2",
          "protein_id": "NP_001137468.1",
          "transcript_support_level": null,
          "aa_start": 787,
          "aa_end": null,
          "aa_length": 953,
          "cds_start": 2361,
          "cds_end": null,
          "cds_length": 2862,
          "cdna_start": 2447,
          "cdna_end": null,
          "cdna_length": 3535,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001143996.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2361A>G",
          "hgvs_p": "p.Thr787Thr",
          "transcript": "NM_001347820.1",
          "protein_id": "NP_001334749.1",
          "transcript_support_level": null,
          "aa_start": 787,
          "aa_end": null,
          "aa_length": 953,
          "cds_start": 2361,
          "cds_end": null,
          "cds_length": 2862,
          "cdna_start": 2409,
          "cdna_end": null,
          "cdna_length": 3497,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001347820.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2361A>G",
          "hgvs_p": "p.Thr787Thr",
          "transcript": "ENST00000419399.4",
          "protein_id": "ENSP00000401356.1",
          "transcript_support_level": 2,
          "aa_start": 787,
          "aa_end": null,
          "aa_length": 953,
          "cds_start": 2361,
          "cds_end": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000419399.4"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2361A>G",
          "hgvs_p": "p.Thr787Thr",
          "transcript": "ENST00000852715.1",
          "protein_id": "ENSP00000522774.1",
          "transcript_support_level": null,
          "aa_start": 787,
          "aa_end": null,
          "aa_length": 953,
          "cds_start": 2361,
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          "cdna_start": 2394,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000852715.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2361A>G",
          "hgvs_p": "p.Thr787Thr",
          "transcript": "ENST00000967766.1",
          "protein_id": "ENSP00000637825.1",
          "transcript_support_level": null,
          "aa_start": 787,
          "aa_end": null,
          "aa_length": 953,
          "cds_start": 2361,
          "cds_end": null,
          "cds_length": 2862,
          "cdna_start": 2595,
          "cdna_end": null,
          "cdna_length": 3676,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000967766.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "OGDHL",
          "gene_hgnc_id": 25590,
          "hgvs_c": "c.2352A>G",
          "hgvs_p": "p.Thr784Thr",
          "transcript": "NM_001347823.1",
          "protein_id": "NP_001334752.1",
          "transcript_support_level": null,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.