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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-56358895-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=56358895&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 56358895,
"ref": "T",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_007057.4",
"consequences": [
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.533A>C",
"hgvs_p": "p.Lys178Thr",
"transcript": "NM_007057.4",
"protein_id": "NP_008988.2",
"transcript_support_level": null,
"aa_start": 178,
"aa_end": null,
"aa_length": 277,
"cds_start": 533,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000373944.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_007057.4"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.533A>C",
"hgvs_p": "p.Lys178Thr",
"transcript": "ENST00000373944.8",
"protein_id": "ENSP00000363055.3",
"transcript_support_level": 1,
"aa_start": 178,
"aa_end": null,
"aa_length": 277,
"cds_start": 533,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_007057.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373944.8"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.533A>C",
"hgvs_p": "p.Lys178Thr",
"transcript": "ENST00000318387.7",
"protein_id": "ENSP00000322850.3",
"transcript_support_level": 1,
"aa_start": 178,
"aa_end": null,
"aa_length": 277,
"cds_start": 533,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000318387.7"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.566A>C",
"hgvs_p": "p.Lys189Thr",
"transcript": "ENST00000920699.1",
"protein_id": "ENSP00000590758.1",
"transcript_support_level": null,
"aa_start": 189,
"aa_end": null,
"aa_length": 288,
"cds_start": 566,
"cds_end": null,
"cds_length": 867,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920699.1"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.536A>C",
"hgvs_p": "p.Lys179Thr",
"transcript": "ENST00000899407.1",
"protein_id": "ENSP00000569466.1",
"transcript_support_level": null,
"aa_start": 179,
"aa_end": null,
"aa_length": 278,
"cds_start": 536,
"cds_end": null,
"cds_length": 837,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000899407.1"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.533A>C",
"hgvs_p": "p.Lys178Thr",
"transcript": "NM_032997.3",
"protein_id": "NP_127490.1",
"transcript_support_level": null,
"aa_start": 178,
"aa_end": null,
"aa_length": 277,
"cds_start": 533,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032997.3"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.533A>C",
"hgvs_p": "p.Lys178Thr",
"transcript": "ENST00000395405.5",
"protein_id": "ENSP00000378801.1",
"transcript_support_level": 2,
"aa_start": 178,
"aa_end": null,
"aa_length": 277,
"cds_start": 533,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000395405.5"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.533A>C",
"hgvs_p": "p.Lys178Thr",
"transcript": "ENST00000899408.1",
"protein_id": "ENSP00000569467.1",
"transcript_support_level": null,
"aa_start": 178,
"aa_end": null,
"aa_length": 277,
"cds_start": 533,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000899408.1"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.530A>C",
"hgvs_p": "p.Lys177Thr",
"transcript": "ENST00000920701.1",
"protein_id": "ENSP00000590760.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 276,
"cds_start": 530,
"cds_end": null,
"cds_length": 831,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920701.1"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.530A>C",
"hgvs_p": "p.Lys177Thr",
"transcript": "ENST00000955112.1",
"protein_id": "ENSP00000625171.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 276,
"cds_start": 530,
"cds_end": null,
"cds_length": 831,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955112.1"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.518A>C",
"hgvs_p": "p.Lys173Thr",
"transcript": "ENST00000920702.1",
"protein_id": "ENSP00000590761.1",
"transcript_support_level": null,
"aa_start": 173,
"aa_end": null,
"aa_length": 272,
"cds_start": 518,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920702.1"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.494A>C",
"hgvs_p": "p.Lys165Thr",
"transcript": "ENST00000920706.1",
"protein_id": "ENSP00000590765.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 264,
"cds_start": 494,
"cds_end": null,
"cds_length": 795,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920706.1"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.494A>C",
"hgvs_p": "p.Lys165Thr",
"transcript": "ENST00000920707.1",
"protein_id": "ENSP00000590766.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 264,
"cds_start": 494,
"cds_end": null,
"cds_length": 795,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920707.1"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.476A>C",
"hgvs_p": "p.Lys159Thr",
"transcript": "ENST00000920700.1",
"protein_id": "ENSP00000590759.1",
"transcript_support_level": null,
"aa_start": 159,
"aa_end": null,
"aa_length": 258,
"cds_start": 476,
"cds_end": null,
"cds_length": 777,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920700.1"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.476A>C",
"hgvs_p": "p.Lys159Thr",
"transcript": "ENST00000920709.1",
"protein_id": "ENSP00000590768.1",
"transcript_support_level": null,
"aa_start": 159,
"aa_end": null,
"aa_length": 258,
"cds_start": 476,
"cds_end": null,
"cds_length": 777,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920709.1"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.533A>C",
"hgvs_p": "p.Lys178Thr",
"transcript": "ENST00000920708.1",
"protein_id": "ENSP00000590767.1",
"transcript_support_level": null,
"aa_start": 178,
"aa_end": null,
"aa_length": 244,
"cds_start": 533,
"cds_end": null,
"cds_length": 735,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920708.1"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.404A>C",
"hgvs_p": "p.Lys135Thr",
"transcript": "ENST00000920698.1",
"protein_id": "ENSP00000590757.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 234,
"cds_start": 404,
"cds_end": null,
"cds_length": 705,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920698.1"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.242A>C",
"hgvs_p": "p.Lys81Thr",
"transcript": "ENST00000899409.1",
"protein_id": "ENSP00000569468.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 180,
"cds_start": 242,
"cds_end": null,
"cds_length": 543,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000899409.1"
},
{
"aa_ref": "K",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.242A>C",
"hgvs_p": "p.Lys81Thr",
"transcript": "ENST00000955111.1",
"protein_id": "ENSP00000625170.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 180,
"cds_start": 242,
"cds_end": null,
"cds_length": 543,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955111.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.519+14A>C",
"hgvs_p": null,
"transcript": "ENST00000899412.1",
"protein_id": "ENSP00000569471.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 236,
"cds_start": null,
"cds_end": null,
"cds_length": 711,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000899412.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.519+14A>C",
"hgvs_p": null,
"transcript": "ENST00000920697.1",
"protein_id": "ENSP00000590756.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 236,
"cds_start": null,
"cds_end": null,
"cds_length": 711,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920697.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ZWINT",
"gene_hgnc_id": 13195,
"hgvs_c": "c.516+14A>C",
"hgvs_p": null,
"transcript": "ENST00000920710.1",
"protein_id": "ENSP00000590769.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 235,
"cds_start": null,
"cds_end": null,
"cds_length": 708,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920710.1"
},
{
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"splice_prediction_selected": "Benign",
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{
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],
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"clinvar_classification": "Uncertain significance",
"clinvar_review_status": "criteria provided, single submitter",
"clinvar_submissions_summary": "US:1",
"phenotype_combined": "not specified",
"pathogenicity_classification_combined": "Uncertain significance",
"custom_annotations": null
}
],
"message": null
}