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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-5926107-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=5926107&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 5926107,
"ref": "A",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000362091.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "c.2722+615A>C",
"hgvs_p": null,
"transcript": "NM_178150.3",
"protein_id": "NP_835363.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1043,
"cds_start": -4,
"cds_end": null,
"cds_length": 3132,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3548,
"mane_select": "ENST00000362091.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "c.2722+615A>C",
"hgvs_p": null,
"transcript": "ENST00000362091.9",
"protein_id": "ENSP00000355415.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1043,
"cds_start": -4,
"cds_end": null,
"cds_length": 3132,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3548,
"mane_select": "NM_178150.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "c.2875+615A>C",
"hgvs_p": null,
"transcript": "ENST00000379999.6",
"protein_id": "ENSP00000369335.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1094,
"cds_start": -4,
"cds_end": null,
"cds_length": 3285,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3702,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "c.2875+615A>C",
"hgvs_p": null,
"transcript": "NM_032807.5",
"protein_id": "NP_116196.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1094,
"cds_start": -4,
"cds_end": null,
"cds_length": 3285,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3702,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "c.2551+615A>C",
"hgvs_p": null,
"transcript": "NM_001258452.2",
"protein_id": "NP_001245381.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 986,
"cds_start": -4,
"cds_end": null,
"cds_length": 2961,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3665,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "c.2551+615A>C",
"hgvs_p": null,
"transcript": "ENST00000397269.7",
"protein_id": "ENSP00000380439.4",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 986,
"cds_start": -4,
"cds_end": null,
"cds_length": 2961,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3640,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "c.2500+615A>C",
"hgvs_p": null,
"transcript": "NM_001258453.2",
"protein_id": "NP_001245382.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 969,
"cds_start": -4,
"cds_end": null,
"cds_length": 2910,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3646,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "n.577+615A>C",
"hgvs_p": null,
"transcript": "ENST00000461504.5",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 835,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "n.82+615A>C",
"hgvs_p": null,
"transcript": "ENST00000470353.1",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 681,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "n.82+615A>C",
"hgvs_p": null,
"transcript": "ENST00000479433.5",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 527,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "n.450+615A>C",
"hgvs_p": null,
"transcript": "ENST00000485290.1",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 2,
"intron_rank": 1,
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"gene_symbol": "FBH1",
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"hgvs_c": "n.229+615A>C",
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"transcript": "ENST00000496013.5",
"protein_id": null,
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"aa_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 23,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "c.3184+615A>C",
"hgvs_p": null,
"transcript": "XM_047425892.1",
"protein_id": "XP_047281848.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 21,
"intron_rank": 18,
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"gene_symbol": "FBH1",
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"hgvs_c": "c.3133+615A>C",
"hgvs_p": null,
"transcript": "XM_047425893.1",
"protein_id": "XP_047281849.1",
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},
{
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],
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"gene_symbol": "FBH1",
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"hgvs_c": "c.2926+615A>C",
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"transcript": "XM_017016842.2",
"protein_id": "XP_016872331.1",
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 22,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "c.2773+615A>C",
"hgvs_p": null,
"transcript": "XM_017016844.3",
"protein_id": "XP_016872333.1",
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},
{
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],
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"gene_symbol": "FBH1",
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"hgvs_c": "c.2773+615A>C",
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"transcript": "XM_047425894.1",
"protein_id": "XP_047281850.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 24,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "FBH1",
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"hgvs_c": "c.2773+615A>C",
"hgvs_p": null,
"transcript": "XM_047425900.1",
"protein_id": "XP_047281856.1",
"transcript_support_level": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 22,
"intron_rank": 19,
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"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "c.2770+615A>C",
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"transcript": "XM_017016845.2",
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},
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],
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"gene_symbol": "FBH1",
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"hgvs_c": "c.2722+615A>C",
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"transcript": "XM_047425895.1",
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},
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],
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"intron_rank": 20,
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"gene_symbol": "FBH1",
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"hgvs_c": "c.2722+615A>C",
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"protein_id": "XP_047281852.1",
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},
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"consequences": [
"intron_variant"
],
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"exon_count": 21,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "c.2551+615A>C",
"hgvs_p": null,
"transcript": "XM_024448240.2",
"protein_id": "XP_024304008.1",
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "FBH1",
"gene_hgnc_id": 13620,
"hgvs_c": "c.2551+615A>C",
"hgvs_p": null,
"transcript": "XM_047425897.1",
"protein_id": "XP_047281853.1",
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"aa_start": null,
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},
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}
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}