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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-59362508-T-TTA (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=59362508&ref=T&alt=TTA&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 59362508,
"ref": "T",
"alt": "TTA",
"effect": "5_prime_UTR_variant",
"transcript": "ENST00000618804.5",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-50_-49dupTA",
"hgvs_p": null,
"transcript": "NM_198215.4",
"protein_id": "NP_937858.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 585,
"cds_start": -4,
"cds_end": null,
"cds_length": 1758,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3328,
"mane_select": "ENST00000618804.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-50_-49dupTA",
"hgvs_p": null,
"transcript": "ENST00000618804.5",
"protein_id": "ENSP00000481854.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 585,
"cds_start": -4,
"cds_end": null,
"cds_length": 1758,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3328,
"mane_select": "NM_198215.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-50_-49dupTA",
"hgvs_p": null,
"transcript": "ENST00000611933.4",
"protein_id": "ENSP00000481830.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 487,
"cds_start": -4,
"cds_end": null,
"cds_length": 1464,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3033,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "n.-50_-49dupTA",
"hgvs_p": null,
"transcript": "ENST00000619059.4",
"protein_id": "ENSP00000484965.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 596,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "n.-50_-49dupTA",
"hgvs_p": null,
"transcript": "ENST00000622363.4",
"protein_id": "ENSP00000484539.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3448,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000287969",
"gene_hgnc_id": null,
"hgvs_c": "n.232_233dupTA",
"hgvs_p": null,
"transcript": "ENST00000834739.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 703,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-50_-49dupTA",
"hgvs_p": null,
"transcript": "ENST00000614220.4",
"protein_id": "ENSP00000483510.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 606,
"cds_start": -4,
"cds_end": null,
"cds_length": 1821,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3388,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-50_-49dupTA",
"hgvs_p": null,
"transcript": "ENST00000621119.4",
"protein_id": "ENSP00000484625.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 605,
"cds_start": -4,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3400,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-50_-49dupTA",
"hgvs_p": null,
"transcript": "NM_001347852.2",
"protein_id": "NP_001334781.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 573,
"cds_start": -4,
"cds_end": null,
"cds_length": 1722,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2129,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-50_-49dupTA",
"hgvs_p": null,
"transcript": "NM_001347849.2",
"protein_id": "NP_001334778.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 572,
"cds_start": -4,
"cds_end": null,
"cds_length": 1719,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2126,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-384_-383dupTA",
"hgvs_p": null,
"transcript": "NM_001166698.2",
"protein_id": "NP_001160170.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 501,
"cds_start": -4,
"cds_end": null,
"cds_length": 1506,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3410,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-384_-383dupTA",
"hgvs_p": null,
"transcript": "ENST00000618427.4",
"protein_id": "ENSP00000480677.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 501,
"cds_start": -4,
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"cds_length": 1506,
"cdna_start": null,
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"cdna_length": 3458,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-415_-414dupTA",
"hgvs_p": null,
"transcript": "NM_001347850.2",
"protein_id": "NP_001334779.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-384_-383dupTA",
"hgvs_p": null,
"transcript": "NM_001347851.2",
"protein_id": "NP_001334780.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
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"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-50_-49dupTA",
"hgvs_p": null,
"transcript": "NM_001001971.3",
"protein_id": "NP_001001971.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 487,
"cds_start": -4,
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"cds_length": 1464,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "n.-50_-49dupTA",
"hgvs_p": null,
"transcript": "ENST00000619059.4",
"protein_id": "ENSP00000484965.1",
"transcript_support_level": 4,
"aa_start": null,
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "n.-50_-49dupTA",
"hgvs_p": null,
"transcript": "ENST00000622363.4",
"protein_id": "ENSP00000484539.1",
"transcript_support_level": 2,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-50_-49dupTA",
"hgvs_p": null,
"transcript": "XM_005269618.5",
"protein_id": "XP_005269675.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 584,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-50_-49dupTA",
"hgvs_p": null,
"transcript": "XM_005269619.5",
"protein_id": "XP_005269676.2",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-227+66_-227+67dupTA",
"hgvs_p": null,
"transcript": "NM_001143773.1",
"protein_id": "NP_001137245.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-226-73_-226-72dupTA",
"hgvs_p": null,
"transcript": "NM_001347840.2",
"protein_id": "NP_001334769.1",
"transcript_support_level": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-312+66_-312+67dupTA",
"hgvs_p": null,
"transcript": "NM_001347847.1",
"protein_id": "NP_001334776.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
"cds_start": -4,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3633,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM13C",
"gene_hgnc_id": 19371,
"hgvs_c": "c.-227+66_-227+67dupTA",
"hgvs_p": null,
"transcript": "ENST00000468840.6",
"protein_id": "ENSP00000423896.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
"cds_start": -4,
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}
],
"message": null
}