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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-6234611-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=6234611&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 6234611,
"ref": "T",
"alt": "C",
"effect": "3_prime_UTR_variant",
"transcript": "NM_001282630.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1669T>C",
"hgvs_p": null,
"transcript": "NM_004566.4",
"protein_id": "NP_004557.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 520,
"cds_start": null,
"cds_end": null,
"cds_length": 1563,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4482,
"mane_select": "ENST00000379775.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004566.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1669T>C",
"hgvs_p": null,
"transcript": "ENST00000379775.9",
"protein_id": "ENSP00000369100.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 520,
"cds_start": null,
"cds_end": null,
"cds_length": 1563,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4482,
"mane_select": "NM_004566.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000379775.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1669T>C",
"hgvs_p": null,
"transcript": "ENST00000379789.8",
"protein_id": "ENSP00000369115.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 500,
"cds_start": null,
"cds_end": null,
"cds_length": 1503,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4157,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000379789.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1669T>C",
"hgvs_p": null,
"transcript": "NM_001282630.3",
"protein_id": "NP_001269559.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 534,
"cds_start": null,
"cds_end": null,
"cds_length": 1605,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4326,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001282630.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1669T>C",
"hgvs_p": null,
"transcript": "ENST00000937282.1",
"protein_id": "ENSP00000607341.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 531,
"cds_start": null,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4515,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937282.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1669T>C",
"hgvs_p": null,
"transcript": "ENST00000900115.1",
"protein_id": "ENSP00000570174.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 520,
"cds_start": null,
"cds_end": null,
"cds_length": 1563,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4370,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900115.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1669T>C",
"hgvs_p": null,
"transcript": "ENST00000937281.1",
"protein_id": "ENSP00000607340.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 520,
"cds_start": null,
"cds_end": null,
"cds_length": 1563,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4352,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937281.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1669T>C",
"hgvs_p": null,
"transcript": "ENST00000937283.1",
"protein_id": "ENSP00000607342.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 517,
"cds_start": null,
"cds_end": null,
"cds_length": 1554,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4472,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937283.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1710T>C",
"hgvs_p": null,
"transcript": "NM_001314063.2",
"protein_id": "NP_001300992.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 514,
"cds_start": null,
"cds_end": null,
"cds_length": 1545,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4505,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001314063.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1710T>C",
"hgvs_p": null,
"transcript": "ENST00000360521.7",
"protein_id": "ENSP00000353712.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 514,
"cds_start": null,
"cds_end": null,
"cds_length": 1545,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4524,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000360521.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1669T>C",
"hgvs_p": null,
"transcript": "NM_001145443.3",
"protein_id": "NP_001138915.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 500,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"feature": "NM_001145443.3"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1710T>C",
"hgvs_p": null,
"transcript": "NM_001323016.2",
"protein_id": "NP_001309945.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "NM_001323016.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
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"gene_symbol": "PFKFB3",
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"hgvs_c": "c.*1669T>C",
"hgvs_p": null,
"transcript": "ENST00000900116.1",
"protein_id": "ENSP00000570175.1",
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"cds_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000900116.1"
},
{
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"strand": true,
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"3_prime_UTR_variant"
],
"exon_rank": 15,
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"exon_count": 15,
"intron_rank": null,
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"gene_symbol": "PFKFB3",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
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"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1669T>C",
"hgvs_p": null,
"transcript": "XM_017016329.2",
"protein_id": "XP_016871818.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"mane_select": null,
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},
{
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"strand": true,
"consequences": [
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],
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"exon_count": 14,
"intron_rank": null,
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"gene_symbol": "PFKFB3",
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"biotype": "protein_coding",
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},
{
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"protein_coding": true,
"strand": true,
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"3_prime_UTR_variant"
],
"exon_rank": 14,
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"exon_count": 14,
"intron_rank": null,
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"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1669T>C",
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"transcript": "XM_047425343.1",
"protein_id": "XP_047281299.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1710T>C",
"hgvs_p": null,
"transcript": "XM_047425344.1",
"protein_id": "XP_047281300.1",
"transcript_support_level": null,
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},
{
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],
"exon_rank": 13,
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"exon_count": 13,
"intron_rank": null,
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"gene_symbol": "PFKFB3",
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},
{
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"strand": true,
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],
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"intron_rank": null,
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"gene_symbol": "PFKFB3",
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"transcript": "XM_047425346.1",
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},
{
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"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
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"intron_rank": null,
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"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1669T>C",
"hgvs_p": null,
"transcript": "XM_005252464.2",
"protein_id": "XP_005252521.1",
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_005252464.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PFKFB3",
"gene_hgnc_id": 8874,
"hgvs_c": "c.*1669T>C",
"hgvs_p": null,
"transcript": "XM_047425347.1",
"protein_id": "XP_047281303.1",
"transcript_support_level": null,
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"aa_end": null,
"aa_length": 442,
"cds_start": null,
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"cds_length": 1329,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047425347.1"
},
{
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"canonical": false,
"protein_coding": true,
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{
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"clinvar_disease": "",
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"custom_annotations": null
}
],
"message": null
}