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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 10-68398295-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=68398295&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "10",
      "pos": 68398295,
      "ref": "T",
      "alt": "C",
      "effect": "intron_variant",
      "transcript": "ENST00000602465.6",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "RUFY2",
          "gene_hgnc_id": 19761,
          "hgvs_c": "c.297-1414A>G",
          "hgvs_p": null,
          "transcript": "NM_001330103.2",
          "protein_id": "NP_001317032.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4269,
          "mane_select": "ENST00000602465.6",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "RUFY2",
          "gene_hgnc_id": 19761,
          "hgvs_c": "c.297-1414A>G",
          "hgvs_p": null,
          "transcript": "ENST00000602465.6",
          "protein_id": "ENSP00000473462.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4269,
          "mane_select": "NM_001330103.2",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "RUFY2",
          "gene_hgnc_id": 19761,
          "hgvs_c": "c.296+3325A>G",
          "hgvs_p": null,
          "transcript": "ENST00000399200.7",
          "protein_id": "ENSP00000382151.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 403,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1212,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2657,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "RUFY2",
          "gene_hgnc_id": 19761,
          "hgvs_c": "n.336-1414A>G",
          "hgvs_p": null,
          "transcript": "ENST00000466493.5",
          "protein_id": "ENSP00000433197.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2110,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "RUFY2",
          "gene_hgnc_id": 19761,
          "hgvs_c": "c.402-1414A>G",
          "hgvs_p": null,
          "transcript": "NM_017987.5",
          "protein_id": "NP_060457.4",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 641,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1926,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4701,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "RUFY2",
          "gene_hgnc_id": 19761,
          "hgvs_c": "c.402-1414A>G",
          "hgvs_p": null,
          "transcript": "ENST00000388768.6",
          "protein_id": "ENSP00000373420.2",
          "transcript_support_level": 2,
          "aa_start": null,
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          "cds_start": -4,
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          "cds_length": 1926,
          "cdna_start": null,
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          "cdna_length": 4502,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 12,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "RUFY2",
          "gene_hgnc_id": 19761,
          "hgvs_c": "c.296+3325A>G",
          "hgvs_p": null,
          "transcript": "NM_001042417.2",
          "protein_id": "NP_001035882.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 403,
          "cds_start": -4,
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          "cds_length": 1212,
          "cdna_start": null,
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          "cdna_length": 2669,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "RUFY2",
          "gene_hgnc_id": 19761,
          "hgvs_c": "c.123-1414A>G",
          "hgvs_p": null,
          "transcript": "NM_001278225.2",
          "protein_id": "NP_001265154.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 379,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1140,
          "cdna_start": null,
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          "cdna_length": 2597,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 12,
          "intron_rank": 2,
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          "gene_symbol": "RUFY2",
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          "hgvs_c": "c.123-1414A>G",
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          "transcript": "ENST00000454950.6",
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        {
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          "gene_symbol": "RUFY2",
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          "hgvs_c": "n.385-1414A>G",
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}