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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-69506950-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=69506950&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 69506950,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_012339.5",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.857C>A",
"hgvs_p": "p.Thr286Lys",
"transcript": "NM_012339.5",
"protein_id": "NP_036471.1",
"transcript_support_level": null,
"aa_start": 286,
"aa_end": null,
"aa_length": 294,
"cds_start": 857,
"cds_end": null,
"cds_length": 885,
"cdna_start": 987,
"cdna_end": null,
"cdna_length": 1703,
"mane_select": "ENST00000373290.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_012339.5"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.857C>A",
"hgvs_p": "p.Thr286Lys",
"transcript": "ENST00000373290.7",
"protein_id": "ENSP00000362387.2",
"transcript_support_level": 1,
"aa_start": 286,
"aa_end": null,
"aa_length": 294,
"cds_start": 857,
"cds_end": null,
"cds_length": 885,
"cdna_start": 987,
"cdna_end": null,
"cdna_length": 1703,
"mane_select": "NM_012339.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373290.7"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.923C>A",
"hgvs_p": "p.Thr308Lys",
"transcript": "ENST00000858304.1",
"protein_id": "ENSP00000528363.1",
"transcript_support_level": null,
"aa_start": 308,
"aa_end": null,
"aa_length": 316,
"cds_start": 923,
"cds_end": null,
"cds_length": 951,
"cdna_start": 1003,
"cdna_end": null,
"cdna_length": 1719,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858304.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.872C>A",
"hgvs_p": "p.Thr291Lys",
"transcript": "ENST00000954128.1",
"protein_id": "ENSP00000624187.1",
"transcript_support_level": null,
"aa_start": 291,
"aa_end": null,
"aa_length": 299,
"cds_start": 872,
"cds_end": null,
"cds_length": 900,
"cdna_start": 993,
"cdna_end": null,
"cdna_length": 1716,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954128.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.809C>A",
"hgvs_p": "p.Thr270Lys",
"transcript": "ENST00000858300.1",
"protein_id": "ENSP00000528359.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 278,
"cds_start": 809,
"cds_end": null,
"cds_length": 837,
"cdna_start": 952,
"cdna_end": null,
"cdna_length": 1671,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858300.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.785C>A",
"hgvs_p": "p.Thr262Lys",
"transcript": "ENST00000858302.1",
"protein_id": "ENSP00000528361.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 270,
"cds_start": 785,
"cds_end": null,
"cds_length": 813,
"cdna_start": 915,
"cdna_end": null,
"cdna_length": 1635,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858302.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.782C>A",
"hgvs_p": "p.Thr261Lys",
"transcript": "ENST00000954132.1",
"protein_id": "ENSP00000624191.1",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 269,
"cds_start": 782,
"cds_end": null,
"cds_length": 810,
"cdna_start": 885,
"cdna_end": null,
"cdna_length": 1600,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954132.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.761C>A",
"hgvs_p": "p.Thr254Lys",
"transcript": "ENST00000954130.1",
"protein_id": "ENSP00000624189.1",
"transcript_support_level": null,
"aa_start": 254,
"aa_end": null,
"aa_length": 262,
"cds_start": 761,
"cds_end": null,
"cds_length": 789,
"cdna_start": 879,
"cdna_end": null,
"cdna_length": 1600,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954130.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.740C>A",
"hgvs_p": "p.Thr247Lys",
"transcript": "ENST00000954129.1",
"protein_id": "ENSP00000624188.1",
"transcript_support_level": null,
"aa_start": 247,
"aa_end": null,
"aa_length": 255,
"cds_start": 740,
"cds_end": null,
"cds_length": 768,
"cdna_start": 861,
"cdna_end": null,
"cdna_length": 1581,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954129.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.671C>A",
"hgvs_p": "p.Thr224Lys",
"transcript": "ENST00000858301.1",
"protein_id": "ENSP00000528360.1",
"transcript_support_level": null,
"aa_start": 224,
"aa_end": null,
"aa_length": 232,
"cds_start": 671,
"cds_end": null,
"cds_length": 699,
"cdna_start": 804,
"cdna_end": null,
"cdna_length": 1522,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858301.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.611C>A",
"hgvs_p": "p.Thr204Lys",
"transcript": "ENST00000954133.1",
"protein_id": "ENSP00000624192.1",
"transcript_support_level": null,
"aa_start": 204,
"aa_end": null,
"aa_length": 212,
"cds_start": 611,
"cds_end": null,
"cds_length": 639,
"cdna_start": 679,
"cdna_end": null,
"cdna_length": 1399,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954133.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.599C>A",
"hgvs_p": "p.Thr200Lys",
"transcript": "ENST00000858303.1",
"protein_id": "ENSP00000528362.1",
"transcript_support_level": null,
"aa_start": 200,
"aa_end": null,
"aa_length": 208,
"cds_start": 599,
"cds_end": null,
"cds_length": 627,
"cdna_start": 717,
"cdna_end": null,
"cdna_length": 1432,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858303.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.596C>A",
"hgvs_p": "p.Thr199Lys",
"transcript": "NM_001351263.2",
"protein_id": "NP_001338192.1",
"transcript_support_level": null,
"aa_start": 199,
"aa_end": null,
"aa_length": 207,
"cds_start": 596,
"cds_end": null,
"cds_length": 624,
"cdna_start": 726,
"cdna_end": null,
"cdna_length": 1442,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351263.2"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.596C>A",
"hgvs_p": "p.Thr199Lys",
"transcript": "ENST00000858299.1",
"protein_id": "ENSP00000528358.1",
"transcript_support_level": null,
"aa_start": 199,
"aa_end": null,
"aa_length": 207,
"cds_start": 596,
"cds_end": null,
"cds_length": 624,
"cdna_start": 1041,
"cdna_end": null,
"cdna_length": 1767,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858299.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.548C>A",
"hgvs_p": "p.Thr183Lys",
"transcript": "ENST00000954131.1",
"protein_id": "ENSP00000624190.1",
"transcript_support_level": null,
"aa_start": 183,
"aa_end": null,
"aa_length": 191,
"cds_start": 548,
"cds_end": null,
"cds_length": 576,
"cdna_start": 651,
"cdna_end": null,
"cdna_length": 1367,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954131.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.662C>A",
"hgvs_p": "p.Thr221Lys",
"transcript": "XM_005269666.5",
"protein_id": "XP_005269723.1",
"transcript_support_level": null,
"aa_start": 221,
"aa_end": null,
"aa_length": 229,
"cds_start": 662,
"cds_end": null,
"cds_length": 690,
"cdna_start": 1846,
"cdna_end": null,
"cdna_length": 2562,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005269666.5"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.509C>A",
"hgvs_p": "p.Thr170Lys",
"transcript": "XM_011539562.3",
"protein_id": "XP_011537864.1",
"transcript_support_level": null,
"aa_start": 170,
"aa_end": null,
"aa_length": 178,
"cds_start": 509,
"cds_end": null,
"cds_length": 537,
"cdna_start": 531,
"cdna_end": null,
"cdna_length": 1247,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011539562.3"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.425C>A",
"hgvs_p": "p.Thr142Lys",
"transcript": "XM_011539563.3",
"protein_id": "XP_011537865.1",
"transcript_support_level": null,
"aa_start": 142,
"aa_end": null,
"aa_length": 150,
"cds_start": 425,
"cds_end": null,
"cds_length": 453,
"cdna_start": 745,
"cdna_end": null,
"cdna_length": 1461,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011539563.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.463-604C>A",
"hgvs_p": null,
"transcript": "ENST00000452130.1",
"protein_id": "ENSP00000404528.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 160,
"cds_start": null,
"cds_end": null,
"cds_length": 483,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 575,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000452130.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.689+2465C>A",
"hgvs_p": null,
"transcript": "XM_017016010.2",
"protein_id": "XP_016871499.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 272,
"cds_start": null,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7368,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017016010.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "c.618+2465C>A",
"hgvs_p": null,
"transcript": "XM_047424930.1",
"protein_id": "XP_047280886.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 209,
"cds_start": null,
"cds_end": null,
"cds_length": 630,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 828,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047424930.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TSPAN15",
"gene_hgnc_id": 23298,
"hgvs_c": "n.789C>A",
"hgvs_p": null,
"transcript": "ENST00000459981.1",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 834,
"mane_select": null,
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{
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"verdict": "Uncertain_significance",
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"custom_annotations": null
}
],
"message": null
}