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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-70114977-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=70114977&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 70114977,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_032797.6",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "NM_032797.6",
"protein_id": "NP_116186.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000307864.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032797.6"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000307864.3",
"protein_id": "ENSP00000312370.1",
"transcript_support_level": 1,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_032797.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000307864.3"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000373248.5",
"protein_id": "ENSP00000362345.1",
"transcript_support_level": 1,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373248.5"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.1147G>T",
"hgvs_p": "p.Ala383Ser",
"transcript": "ENST00000856761.1",
"protein_id": "ENSP00000526820.1",
"transcript_support_level": null,
"aa_start": 383,
"aa_end": null,
"aa_length": 451,
"cds_start": 1147,
"cds_end": null,
"cds_length": 1356,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856761.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.1147G>T",
"hgvs_p": "p.Ala383Ser",
"transcript": "ENST00000959270.1",
"protein_id": "ENSP00000629329.1",
"transcript_support_level": null,
"aa_start": 383,
"aa_end": null,
"aa_length": 451,
"cds_start": 1147,
"cds_end": null,
"cds_length": 1356,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000959270.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.955G>T",
"hgvs_p": "p.Ala319Ser",
"transcript": "ENST00000959267.1",
"protein_id": "ENSP00000629326.1",
"transcript_support_level": null,
"aa_start": 319,
"aa_end": null,
"aa_length": 387,
"cds_start": 955,
"cds_end": null,
"cds_length": 1164,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000959267.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.955G>T",
"hgvs_p": "p.Ala319Ser",
"transcript": "ENST00000959269.1",
"protein_id": "ENSP00000629328.1",
"transcript_support_level": null,
"aa_start": 319,
"aa_end": null,
"aa_length": 387,
"cds_start": 955,
"cds_end": null,
"cds_length": 1164,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000959269.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "NM_001198696.2",
"protein_id": "NP_001185625.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001198696.2"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000613322.4",
"protein_id": "ENSP00000478931.1",
"transcript_support_level": 5,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000613322.4"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000856741.1",
"protein_id": "ENSP00000526800.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856741.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000856742.1",
"protein_id": "ENSP00000526801.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856742.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000856743.1",
"protein_id": "ENSP00000526802.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856743.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000856744.1",
"protein_id": "ENSP00000526803.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856744.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000856745.1",
"protein_id": "ENSP00000526804.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856745.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000856746.1",
"protein_id": "ENSP00000526805.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856746.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000856747.1",
"protein_id": "ENSP00000526806.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856747.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000856748.1",
"protein_id": "ENSP00000526807.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856748.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000856750.1",
"protein_id": "ENSP00000526809.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856750.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000856751.1",
"protein_id": "ENSP00000526810.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856751.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000856752.1",
"protein_id": "ENSP00000526811.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856752.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000856754.1",
"protein_id": "ENSP00000526813.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856754.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AIFM2",
"gene_hgnc_id": 21411,
"hgvs_c": "c.913G>T",
"hgvs_p": "p.Ala305Ser",
"transcript": "ENST00000856755.1",
"protein_id": "ENSP00000526814.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 373,
"cds_start": 913,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
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}
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}