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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-76877888-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=76877888&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 76877888,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001322830.2",
"consequences": [
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3368A>G",
"hgvs_p": "p.Lys1123Arg",
"transcript": "ENST00000640807.1",
"protein_id": "ENSP00000491555.1",
"transcript_support_level": 1,
"aa_start": 1123,
"aa_end": null,
"aa_length": 1128,
"cds_start": 3368,
"cds_end": null,
"cds_length": 3387,
"cdna_start": 3368,
"cdna_end": null,
"cdna_length": 3387,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3113A>G",
"hgvs_p": "p.Lys1038Arg",
"transcript": "ENST00000604624.6",
"protein_id": "ENSP00000473714.2",
"transcript_support_level": 1,
"aa_start": 1038,
"aa_end": null,
"aa_length": 1043,
"cds_start": 3113,
"cds_end": null,
"cds_length": 3132,
"cdna_start": 3113,
"cdna_end": null,
"cdna_length": 11400,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"splice_region_variant",
"non_coding_transcript_exon_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "n.*2394A>G",
"hgvs_p": null,
"transcript": "ENST00000639691.1",
"protein_id": "ENSP00000491040.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3145,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"splice_region_variant",
"non_coding_transcript_exon_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "n.3739A>G",
"hgvs_p": null,
"transcript": "ENST00000639851.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3866,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "n.*2394A>G",
"hgvs_p": null,
"transcript": "ENST00000639691.1",
"protein_id": "ENSP00000491040.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3145,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 31,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3592A>G",
"hgvs_p": "p.Lys1198Glu",
"transcript": "ENST00000639591.1",
"protein_id": "ENSP00000492793.1",
"transcript_support_level": 5,
"aa_start": 1198,
"aa_end": null,
"aa_length": 1246,
"cds_start": 3592,
"cds_end": null,
"cds_length": 3741,
"cdna_start": 3725,
"cdna_end": null,
"cdna_length": 3888,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 31,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3568A>G",
"hgvs_p": "p.Lys1190Glu",
"transcript": "ENST00000640605.1",
"protein_id": "ENSP00000491435.1",
"transcript_support_level": 5,
"aa_start": 1190,
"aa_end": null,
"aa_length": 1238,
"cds_start": 3568,
"cds_end": null,
"cds_length": 3717,
"cdna_start": 3701,
"cdna_end": null,
"cdna_length": 3864,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3692A>G",
"hgvs_p": "p.Lys1231Arg",
"transcript": "ENST00000639544.1",
"protein_id": "ENSP00000492075.1",
"transcript_support_level": 5,
"aa_start": 1231,
"aa_end": null,
"aa_length": 1236,
"cds_start": 3692,
"cds_end": null,
"cds_length": 3711,
"cdna_start": 3692,
"cdna_end": null,
"cdna_length": 3711,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 31,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3620A>G",
"hgvs_p": "p.Lys1207Arg",
"transcript": "NM_001322830.2",
"protein_id": "NP_001309759.1",
"transcript_support_level": null,
"aa_start": 1207,
"aa_end": null,
"aa_length": 1212,
"cds_start": 3620,
"cds_end": null,
"cds_length": 3639,
"cdna_start": 3786,
"cdna_end": null,
"cdna_length": 12072,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 31,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3620A>G",
"hgvs_p": "p.Lys1207Arg",
"transcript": "ENST00000638223.1",
"protein_id": "ENSP00000492492.1",
"transcript_support_level": 5,
"aa_start": 1207,
"aa_end": null,
"aa_length": 1212,
"cds_start": 3620,
"cds_end": null,
"cds_length": 3639,
"cdna_start": 3620,
"cdna_end": null,
"cdna_length": 4340,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3611A>G",
"hgvs_p": "p.Lys1204Arg",
"transcript": "ENST00000372443.6",
"protein_id": "ENSP00000361520.2",
"transcript_support_level": 5,
"aa_start": 1204,
"aa_end": null,
"aa_length": 1209,
"cds_start": 3611,
"cds_end": null,
"cds_length": 3630,
"cdna_start": 4338,
"cdna_end": null,
"cdna_length": 5059,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3608A>G",
"hgvs_p": "p.Lys1203Arg",
"transcript": "ENST00000639913.1",
"protein_id": "ENSP00000492241.1",
"transcript_support_level": 5,
"aa_start": 1203,
"aa_end": null,
"aa_length": 1208,
"cds_start": 3608,
"cds_end": null,
"cds_length": 3627,
"cdna_start": 3785,
"cdna_end": null,
"cdna_length": 12071,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3605A>G",
"hgvs_p": "p.Lys1202Arg",
"transcript": "NM_001437423.1",
"protein_id": "NP_001424352.1",
"transcript_support_level": null,
"aa_start": 1202,
"aa_end": null,
"aa_length": 1207,
"cds_start": 3605,
"cds_end": null,
"cds_length": 3624,
"cdna_start": 3771,
"cdna_end": null,
"cdna_length": 12057,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 31,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3442A>G",
"hgvs_p": "p.Lys1148Glu",
"transcript": "ENST00000639498.1",
"protein_id": "ENSP00000492835.1",
"transcript_support_level": 5,
"aa_start": 1148,
"aa_end": null,
"aa_length": 1196,
"cds_start": 3442,
"cds_end": null,
"cds_length": 3591,
"cdna_start": 3442,
"cdna_end": null,
"cdna_length": 4711,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3406A>G",
"hgvs_p": "p.Lys1136Glu",
"transcript": "ENST00000639344.1",
"protein_id": "ENSP00000492559.1",
"transcript_support_level": 5,
"aa_start": 1136,
"aa_end": null,
"aa_length": 1184,
"cds_start": 3406,
"cds_end": null,
"cds_length": 3555,
"cdna_start": 3408,
"cdna_end": null,
"cdna_length": 4073,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3530A>G",
"hgvs_p": "p.Lys1177Arg",
"transcript": "NM_001014797.3",
"protein_id": "NP_001014797.1",
"transcript_support_level": null,
"aa_start": 1177,
"aa_end": null,
"aa_length": 1182,
"cds_start": 3530,
"cds_end": null,
"cds_length": 3549,
"cdna_start": 3696,
"cdna_end": null,
"cdna_length": 11982,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3527A>G",
"hgvs_p": "p.Lys1176Arg",
"transcript": "ENST00000638991.1",
"protein_id": "ENSP00000490978.1",
"transcript_support_level": 5,
"aa_start": 1176,
"aa_end": null,
"aa_length": 1181,
"cds_start": 3527,
"cds_end": null,
"cds_length": 3546,
"cdna_start": 3704,
"cdna_end": null,
"cdna_length": 11990,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3518A>G",
"hgvs_p": "p.Lys1173Arg",
"transcript": "NM_001410940.1",
"protein_id": "NP_001397869.1",
"transcript_support_level": null,
"aa_start": 1173,
"aa_end": null,
"aa_length": 1178,
"cds_start": 3518,
"cds_end": null,
"cds_length": 3537,
"cdna_start": 3684,
"cdna_end": null,
"cdna_length": 11970,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3518A>G",
"hgvs_p": "p.Lys1173Arg",
"transcript": "ENST00000639601.1",
"protein_id": "ENSP00000492806.1",
"transcript_support_level": 5,
"aa_start": 1173,
"aa_end": null,
"aa_length": 1178,
"cds_start": 3518,
"cds_end": null,
"cds_length": 3537,
"cdna_start": 3634,
"cdna_end": null,
"cdna_length": 11920,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 31,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3518A>G",
"hgvs_p": "p.Lys1173Arg",
"transcript": "ENST00000640029.1",
"protein_id": "ENSP00000491463.1",
"transcript_support_level": 5,
"aa_start": 1173,
"aa_end": null,
"aa_length": 1178,
"cds_start": 3518,
"cds_end": null,
"cds_length": 3537,
"cdna_start": 3518,
"cdna_end": null,
"cdna_length": 3537,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3509A>G",
"hgvs_p": "p.Lys1170Arg",
"transcript": "ENST00000640934.1",
"protein_id": "ENSP00000491539.1",
"transcript_support_level": 5,
"aa_start": 1170,
"aa_end": null,
"aa_length": 1175,
"cds_start": 3509,
"cds_end": null,
"cds_length": 3528,
"cdna_start": 3509,
"cdna_end": null,
"cdna_length": 3528,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNMA1",
"gene_hgnc_id": 6284,
"hgvs_c": "c.3410A>G",
"hgvs_p": "p.Lys1137Arg",
"transcript": "ENST00000404857.6",
"protein_id": "ENSP00000385806.3",
"transcript_support_level": 5,
"aa_start": 1137,
"aa_end": null,
"aa_length": 1142,
"cds_start": 3410,
"cds_end": null,
"cds_length": 3429,
"cdna_start": 3410,
"cdna_end": null,
"cdna_length": 3429,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
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