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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 10-77926396-C-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=77926396&ref=C&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "10",
      "pos": 77926396,
      "ref": "C",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_004747.4",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DLG5",
          "gene_hgnc_id": 2904,
          "hgvs_c": "c.125G>T",
          "hgvs_p": "p.Arg42Leu",
          "transcript": "NM_004747.4",
          "protein_id": "NP_004738.3",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 1919,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 5760,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000372391.7",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_004747.4"
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DLG5",
          "gene_hgnc_id": 2904,
          "hgvs_c": "c.125G>T",
          "hgvs_p": "p.Arg42Leu",
          "transcript": "ENST00000372391.7",
          "protein_id": "ENSP00000361467.2",
          "transcript_support_level": 1,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 1919,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 5760,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_004747.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000372391.7"
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DLG5",
          "gene_hgnc_id": 2904,
          "hgvs_c": "c.125G>T",
          "hgvs_p": "p.Arg42Leu",
          "transcript": "ENST00000928380.1",
          "protein_id": "ENSP00000598439.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 1915,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 5748,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000928380.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DLG5",
          "gene_hgnc_id": 2904,
          "hgvs_c": "c.125G>T",
          "hgvs_p": "p.Arg42Leu",
          "transcript": "ENST00000928379.1",
          "protein_id": "ENSP00000598438.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 1888,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 5667,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000928379.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DLG5",
          "gene_hgnc_id": 2904,
          "hgvs_c": "c.125G>T",
          "hgvs_p": "p.Arg42Leu",
          "transcript": "ENST00000962015.1",
          "protein_id": "ENSP00000632074.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 1548,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 4647,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000962015.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DLG5",
          "gene_hgnc_id": 2904,
          "hgvs_c": "c.125G>T",
          "hgvs_p": "p.Arg42Leu",
          "transcript": "XM_005270276.5",
          "protein_id": "XP_005270333.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 1915,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 5748,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_005270276.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DLG5",
          "gene_hgnc_id": 2904,
          "hgvs_c": "c.125G>T",
          "hgvs_p": "p.Arg42Leu",
          "transcript": "XM_011540346.3",
          "protein_id": "XP_011538648.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 1680,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 5043,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011540346.3"
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DLG5",
          "gene_hgnc_id": 2904,
          "hgvs_c": "c.125G>T",
          "hgvs_p": "p.Arg42Leu",
          "transcript": "XM_006718056.4",
          "protein_id": "XP_006718119.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 1579,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 4740,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_006718056.4"
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DLG5",
          "gene_hgnc_id": 2904,
          "hgvs_c": "c.125G>T",
          "hgvs_p": "p.Arg42Leu",
          "transcript": "XM_047426002.1",
          "protein_id": "XP_047281958.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 1452,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 4359,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047426002.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DLG5",
          "gene_hgnc_id": 2904,
          "hgvs_c": "c.125G>T",
          "hgvs_p": "p.Arg42Leu",
          "transcript": "XM_006718057.4",
          "protein_id": "XP_006718120.1",
          "transcript_support_level": null,
          "aa_start": 42,
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          "aa_length": 1342,
          "cds_start": 125,
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          "cds_length": 4029,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_006718057.4"
        },
        {
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          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
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          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DLG5",
          "gene_hgnc_id": 2904,
          "hgvs_c": "c.125G>T",
          "hgvs_p": "p.Arg42Leu",
          "transcript": "XM_047426003.1",
          "protein_id": "XP_047281959.1",
          "transcript_support_level": null,
          "aa_start": 42,
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          "aa_length": 1202,
          "cds_start": 125,
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          "cds_length": 3609,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
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        {
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          "exon_count": 32,
          "intron_rank": 1,
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          "gene_symbol": "DLG5",
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          "hgvs_c": "c.-27+14274G>T",
          "hgvs_p": null,
          "transcript": "XM_047425998.1",
          "protein_id": "XP_047281954.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 1809,
          "cds_start": null,
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          "cdna_start": null,
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        {
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          "strand": true,
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          ],
          "exon_rank": null,
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          "exon_count": 2,
          "intron_rank": 1,
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          "gene_symbol": "DLG5-AS1",
          "gene_hgnc_id": 45109,
          "hgvs_c": "n.627+119C>A",
          "hgvs_p": null,
          "transcript": "ENST00000842780.1",
          "protein_id": null,
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          "biotype": "pseudogene",
          "feature": "ENST00000842780.1"
        },
        {
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": 1,
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          "gene_symbol": "DLG5-AS1",
          "gene_hgnc_id": 45109,
          "hgvs_c": "n.461+252C>A",
          "hgvs_p": null,
          "transcript": "ENST00000842781.1",
          "protein_id": null,
          "transcript_support_level": null,
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        {
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          "hgvs_c": "n.260+119C>A",
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          "transcript": "ENST00000842782.1",
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          "biotype": "pseudogene",
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        },
        {
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          ],
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          "exon_count": 2,
          "intron_rank": 1,
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          "gene_symbol": "DLG5-AS1",
          "gene_hgnc_id": 45109,
          "hgvs_c": "n.240+137C>A",
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          "transcript": "ENST00000842783.1",
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        {
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          ],
          "exon_rank": null,
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          "intron_rank": 1,
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          "gene_symbol": "DLG5-AS1",
          "gene_hgnc_id": 45109,
          "hgvs_c": "n.191+119C>A",
          "hgvs_p": null,
          "transcript": "ENST00000842784.1",
          "protein_id": null,
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        {
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        {
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        {
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          ],
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          "gene_symbol": "DLG5-AS1",
          "gene_hgnc_id": 45109,
          "hgvs_c": "n.186+119C>A",
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          "transcript": "ENST00000842787.1",
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          "cdna_start": null,
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        },
        {
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          "strand": true,
          "consequences": [
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          ],
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          "exon_count": 4,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "DLG5-AS1",
          "gene_hgnc_id": 45109,
          "hgvs_c": "n.133+119C>A",
          "hgvs_p": null,
          "transcript": "ENST00000842788.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000842788.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "DLG5-AS1",
          "gene_hgnc_id": 45109,
          "hgvs_c": "n.63+119C>A",
          "hgvs_p": null,
          "transcript": "ENST00000842789.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000842789.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "DLG5-AS1",
          "gene_hgnc_id": 45109,
          "hgvs_c": "n.51+119C>A",
          "hgvs_p": null,
          "transcript": "ENST00000842790.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000842790.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "DLG5-AS1",
          "gene_hgnc_id": 45109,
          "hgvs_c": "n.33+119C>A",
          "hgvs_p": null,
          "transcript": "ENST00000842791.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000842791.1"
        }
      ],
      "gene_symbol": "DLG5",
      "gene_hgnc_id": 2904,
      "dbsnp": "rs779175990",
      "frequency_reference_population": 0.0000031458649,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 5,
      "gnomad_exomes_af": 6.9578e-7,
      "gnomad_genomes_af": 0.0000262895,
      "gnomad_exomes_ac": 1,
      "gnomad_genomes_ac": 4,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.06704643368721008,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.026,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.1424,
      "alphamissense_prediction": "Benign",
      "bayesdelnoaf_score": -0.38,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 0.769,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -2,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong",
      "acmg_by_gene": [
        {
          "score": -2,
          "benign_score": 4,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Strong"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_004747.4",
          "gene_symbol": "DLG5",
          "hgnc_id": 2904,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AD,AR",
          "hgvs_c": "c.125G>T",
          "hgvs_p": "p.Arg42Leu"
        },
        {
          "score": -2,
          "benign_score": 4,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Strong"
          ],
          "verdict": "Likely_benign",
          "transcript": "ENST00000842780.1",
          "gene_symbol": "DLG5-AS1",
          "hgnc_id": 45109,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.627+119C>A",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}