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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-80425873-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=80425873&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 80425873,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_032333.5",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "NM_032333.5",
"protein_id": "NP_115709.3",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000606162.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032333.5"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000606162.6",
"protein_id": "ENSP00000482445.1",
"transcript_support_level": 1,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_032333.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000606162.6"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000372187.9",
"protein_id": "ENSP00000361261.5",
"transcript_support_level": 1,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000372187.9"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "NM_001243778.2",
"protein_id": "NP_001230707.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001243778.2"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "NM_001243779.2",
"protein_id": "NP_001230708.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001243779.2"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "NM_001243780.2",
"protein_id": "NP_001230709.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001243780.2"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000372181.1",
"protein_id": "ENSP00000361254.1",
"transcript_support_level": 2,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000372181.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000372188.5",
"protein_id": "ENSP00000361262.1",
"transcript_support_level": 2,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000372188.5"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000615554.4",
"protein_id": "ENSP00000478152.1",
"transcript_support_level": 5,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000615554.4"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000870438.1",
"protein_id": "ENSP00000540497.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870438.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000870439.1",
"protein_id": "ENSP00000540498.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870439.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000870440.1",
"protein_id": "ENSP00000540499.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870440.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000870441.1",
"protein_id": "ENSP00000540500.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870441.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000870442.1",
"protein_id": "ENSP00000540501.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870442.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000870443.1",
"protein_id": "ENSP00000540502.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870443.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000870444.1",
"protein_id": "ENSP00000540503.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870444.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000870446.1",
"protein_id": "ENSP00000540505.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870446.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000870447.1",
"protein_id": "ENSP00000540506.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870447.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000870448.1",
"protein_id": "ENSP00000540507.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870448.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000870449.1",
"protein_id": "ENSP00000540508.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870449.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000870450.1",
"protein_id": "ENSP00000540509.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870450.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRXL2A",
"gene_hgnc_id": 28651,
"hgvs_c": "c.278C>T",
"hgvs_p": "p.Ala93Val",
"transcript": "ENST00000923208.1",
"protein_id": "ENSP00000593267.1",
"transcript_support_level": null,
"aa_start": 93,
"aa_end": null,
"aa_length": 229,
"cds_start": 278,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923208.1"
},
{
"aa_ref": "A",
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