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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-82289009-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=82289009&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 82289009,
"ref": "A",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000372141.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NRG3",
"gene_hgnc_id": 7999,
"hgvs_c": "c.824-69730A>T",
"hgvs_p": null,
"transcript": "NM_001010848.4",
"protein_id": "NP_001010848.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 696,
"cds_start": -4,
"cds_end": null,
"cds_length": 2091,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3811,
"mane_select": "ENST00000372141.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NRG3",
"gene_hgnc_id": 7999,
"hgvs_c": "c.824-69730A>T",
"hgvs_p": null,
"transcript": "ENST00000372141.7",
"protein_id": "ENSP00000361214.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 696,
"cds_start": -4,
"cds_end": null,
"cds_length": 2091,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3811,
"mane_select": "NM_001010848.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NRG3",
"gene_hgnc_id": 7999,
"hgvs_c": "c.824-69730A>T",
"hgvs_p": null,
"transcript": "ENST00000404547.5",
"protein_id": "ENSP00000384796.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 720,
"cds_start": -4,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2163,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NRG3",
"gene_hgnc_id": 7999,
"hgvs_c": "c.313+56190A>T",
"hgvs_p": null,
"transcript": "ENST00000556918.5",
"protein_id": "ENSP00000451376.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 526,
"cds_start": -4,
"cds_end": null,
"cds_length": 1581,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1581,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NRG3",
"gene_hgnc_id": 7999,
"hgvs_c": "c.236-69730A>T",
"hgvs_p": null,
"transcript": "ENST00000404576.6",
"protein_id": "ENSP00000385804.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 500,
"cds_start": -4,
"cds_end": null,
"cds_length": 1503,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1503,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NRG3",
"gene_hgnc_id": 7999,
"hgvs_c": "c.161-69730A>T",
"hgvs_p": null,
"transcript": "ENST00000372142.6",
"protein_id": "ENSP00000361215.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 499,
"cds_start": -4,
"cds_end": null,
"cds_length": 1500,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3136,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NRG3",
"gene_hgnc_id": 7999,
"hgvs_c": "n.136-69730A>T",
"hgvs_p": null,
"transcript": "ENST00000555784.5",
"protein_id": "ENSP00000451858.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1606,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NRG3",
"gene_hgnc_id": 7999,
"hgvs_c": "c.824-69730A>T",
"hgvs_p": null,
"transcript": "NM_001370084.1",
"protein_id": "NP_001357013.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 720,
"cds_start": -4,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3883,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NRG3",
"gene_hgnc_id": 7999,
"hgvs_c": "c.824-69730A>T",
"hgvs_p": null,
"transcript": "NM_001370081.1",
"protein_id": "NP_001357010.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 696,
"cds_start": -4,
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"cds_length": 2091,
"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 1,
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"gene_symbol": "NRG3",
"gene_hgnc_id": 7999,
"hgvs_c": "c.824-69730A>T",
"hgvs_p": null,
"transcript": "NM_001165972.1",
"protein_id": "NP_001159444.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 695,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 3,
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"gene_symbol": "NRG3",
"gene_hgnc_id": 7999,
"hgvs_c": "c.256+56190A>T",
"hgvs_p": null,
"transcript": "NM_001370082.1",
"protein_id": "NP_001357011.1",
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},
{
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],
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"gene_symbol": "NRG3",
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"transcript": "NM_001165973.2",
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},
{
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],
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"gene_symbol": "NRG3",
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"transcript": "NM_001370083.1",
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},
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],
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"gene_symbol": "NRG3",
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"hgvs_c": "n.*372-69730A>T",
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"transcript": "ENST00000602794.5",
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},
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],
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},
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],
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},
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],
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"gene_symbol": "NRG3",
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"hgvs_c": "c.901+56190A>T",
"hgvs_p": null,
"transcript": "XM_017015573.3",
"protein_id": "XP_016871062.1",
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"intron_rank": 2,
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},
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],
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"gene_symbol": "NRG3",
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"hgvs_c": "c.901+56190A>T",
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"transcript": "XM_017015577.3",
"protein_id": "XP_016871066.1",
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},
{
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],
"exon_rank": null,
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"exon_count": 10,
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"gene_symbol": "NRG3",
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"transcript": "XM_017015578.3",
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}