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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 10-87094575-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=87094575&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "10",
      "pos": 87094575,
      "ref": "G",
      "alt": "A",
      "effect": "synonymous_variant",
      "transcript": "ENST00000277865.5",
      "consequences": [
        {
          "aa_ref": "N",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GLUD1",
          "gene_hgnc_id": 4335,
          "hgvs_c": "c.195C>T",
          "hgvs_p": "p.Asn65Asn",
          "transcript": "NM_005271.5",
          "protein_id": "NP_005262.1",
          "transcript_support_level": null,
          "aa_start": 65,
          "aa_end": null,
          "aa_length": 558,
          "cds_start": 195,
          "cds_end": null,
          "cds_length": 1677,
          "cdna_start": 269,
          "cdna_end": null,
          "cdna_length": 3300,
          "mane_select": "ENST00000277865.5",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "N",
          "aa_alt": "N",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GLUD1",
          "gene_hgnc_id": 4335,
          "hgvs_c": "c.195C>T",
          "hgvs_p": "p.Asn65Asn",
          "transcript": "ENST00000277865.5",
          "protein_id": "ENSP00000277865.4",
          "transcript_support_level": 1,
          "aa_start": 65,
          "aa_end": null,
          "aa_length": 558,
          "cds_start": 195,
          "cds_end": null,
          "cds_length": 1677,
          "cdna_start": 269,
          "cdna_end": null,
          "cdna_length": 3300,
          "mane_select": "NM_005271.5",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "N",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GLUD1",
          "gene_hgnc_id": 4335,
          "hgvs_c": "c.195C>T",
          "hgvs_p": "p.Asn65Asn",
          "transcript": "ENST00000684338.1",
          "protein_id": "ENSP00000507457.1",
          "transcript_support_level": null,
          "aa_start": 65,
          "aa_end": null,
          "aa_length": 532,
          "cds_start": 195,
          "cds_end": null,
          "cds_length": 1599,
          "cdna_start": 195,
          "cdna_end": null,
          "cdna_length": 2979,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "N",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GLUD1",
          "gene_hgnc_id": 4335,
          "hgvs_c": "c.195C>T",
          "hgvs_p": "p.Asn65Asn",
          "transcript": "ENST00000684201.1",
          "protein_id": "ENSP00000507887.1",
          "transcript_support_level": null,
          "aa_start": 65,
          "aa_end": null,
          "aa_length": 466,
          "cds_start": 195,
          "cds_end": null,
          "cds_length": 1401,
          "cdna_start": 202,
          "cdna_end": null,
          "cdna_length": 2623,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GLUD1",
          "gene_hgnc_id": 4335,
          "hgvs_c": "n.195C>T",
          "hgvs_p": null,
          "transcript": "ENST00000682622.1",
          "protein_id": "ENSP00000506732.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2958,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GLUD1",
          "gene_hgnc_id": 4335,
          "hgvs_c": "n.93C>T",
          "hgvs_p": null,
          "transcript": "ENST00000682833.1",
          "protein_id": "ENSP00000507701.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1732,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GLUD1",
          "gene_hgnc_id": 4335,
          "hgvs_c": "c.-534C>T",
          "hgvs_p": null,
          "transcript": "NM_001318904.2",
          "protein_id": "NP_001305833.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 391,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1176,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3527,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GLUD1",
          "gene_hgnc_id": 4335,
          "hgvs_c": "c.-660C>T",
          "hgvs_p": null,
          "transcript": "NM_001318905.2",
          "protein_id": "NP_001305834.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 391,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1176,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3653,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GLUD1",
          "gene_hgnc_id": 4335,
          "hgvs_c": "c.-367C>T",
          "hgvs_p": null,
          "transcript": "NM_001318906.2",
          "protein_id": "NP_001305835.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 391,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1176,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3360,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SHLD2",
          "gene_hgnc_id": 28773,
          "hgvs_c": "c.-275G>A",
          "hgvs_p": null,
          "transcript": "ENST00000437629.6",
          "protein_id": "ENSP00000475647.1",
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 92,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 280,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 969,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SHLD2",
          "gene_hgnc_id": 28773,
          "hgvs_c": "c.-219G>A",
          "hgvs_p": null,
          "transcript": "XM_047425370.1",
          "protein_id": "XP_047281326.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 952,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2859,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3962,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SHLD2",
          "gene_hgnc_id": 28773,
          "hgvs_c": "c.-219G>A",
          "hgvs_p": null,
          "transcript": "XM_047425371.1",
          "protein_id": "XP_047281327.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "cds_start": -4,
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          "cdna_start": null,
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          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SHLD2",
          "gene_hgnc_id": 28773,
          "hgvs_c": "c.-219G>A",
          "hgvs_p": null,
          "transcript": "XM_047425372.1",
          "protein_id": "XP_047281328.1",
          "transcript_support_level": null,
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          "aa_length": 904,
          "cds_start": -4,
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          "cdna_start": null,
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          "cdna_length": 3818,
          "mane_select": null,
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        },
        {
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          "strand": true,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
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          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SHLD2",
          "gene_hgnc_id": 28773,
          "hgvs_c": "c.-219G>A",
          "hgvs_p": null,
          "transcript": "XM_047425373.1",
          "protein_id": "XP_047281329.1",
          "transcript_support_level": null,
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          "cds_start": -4,
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          "cdna_start": null,
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          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
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          "consequences": [
            "5_prime_UTR_variant"
          ],
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          "exon_count": 9,
          "intron_rank": null,
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          "gene_symbol": "SHLD2",
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          "hgvs_c": "c.-219G>A",
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        {
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          ],
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          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SHLD2",
          "gene_hgnc_id": 28773,
          "hgvs_c": "c.-219G>A",
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          "transcript": "XM_047425375.1",
          "protein_id": "XP_047281331.1",
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          "aa_length": 866,
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          "mane_select": null,
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          "feature": null
        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 1,
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          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SHLD2",
          "gene_hgnc_id": 28773,
          "hgvs_c": "c.-219G>A",
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          "transcript": "XM_047425376.1",
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          "cdna_start": null,
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        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "5_prime_UTR_variant"
          ],
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          "exon_count": 8,
          "intron_rank": null,
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          "gene_symbol": "SHLD2",
          "gene_hgnc_id": 28773,
          "hgvs_c": "c.-219G>A",
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        {
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          ],
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          "exon_count": 10,
          "intron_rank": null,
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          "gene_symbol": "SHLD2",
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          "hgvs_c": "c.-219G>A",
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          "transcript": "XM_047425378.1",
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        },
        {
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          "consequences": [
            "5_prime_UTR_variant"
          ],
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          "exon_count": 9,
          "intron_rank": null,
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          "gene_symbol": "SHLD2",
          "gene_hgnc_id": 28773,
          "hgvs_c": "c.-219G>A",
          "hgvs_p": null,
          "transcript": "XM_047425379.1",
          "protein_id": "XP_047281335.1",
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          "aa_start": null,
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          "cds_start": -4,
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          "cds_length": 1668,
          "cdna_start": null,
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          "cdna_length": 2771,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SHLD2",
          "gene_hgnc_id": 28773,
          "hgvs_c": "c.-219G>A",
          "hgvs_p": null,
          "transcript": "XM_047425380.1",
          "protein_id": "XP_047281336.1",
          "transcript_support_level": null,
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          "aa_length": 486,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2564,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GLUD1",
          "gene_hgnc_id": 4335,
          "hgvs_c": "n.-115C>T",
          "hgvs_p": null,
          "transcript": "ENST00000682396.1",
          "protein_id": "ENSP00000506764.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2919,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GLUD1",
          "gene_hgnc_id": 4335,
          "hgvs_c": "n.-127C>T",
          "hgvs_p": null,
          "transcript": "ENST00000683022.1",
          "protein_id": "ENSP00000508288.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2949,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GLUD1",
          "gene_hgnc_id": 4335,
          "hgvs_c": "n.-178C>T",
          "hgvs_p": null,
          "transcript": "ENST00000684032.1",
          "protein_id": "ENSP00000506969.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2759,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        }
      ],
      "gene_symbol": "GLUD1",
      "gene_hgnc_id": 4335,
      "dbsnp": "rs760817479",
      "frequency_reference_population": 0.000017993869,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 29,
      "gnomad_exomes_af": 0.00000890684,
      "gnomad_genomes_af": 0.000105188,
      "gnomad_exomes_ac": 13,
      "gnomad_genomes_ac": 16,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.09300000220537186,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "REVEL",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.093,
      "revel_prediction": "Benign",
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.5,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 2.017,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -11,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Moderate,BP6_Very_Strong,BP7",
      "acmg_by_gene": [
        {
          "score": -11,
          "benign_score": 11,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Moderate",
            "BP6_Very_Strong",
            "BP7"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000277865.5",
          "gene_symbol": "GLUD1",
          "hgnc_id": 4335,
          "effects": [
            "synonymous_variant"
          ],
          "inheritance_mode": "AD,AR",
          "hgvs_c": "c.195C>T",
          "hgvs_p": "p.Asn65Asn"
        },
        {
          "score": -10,
          "benign_score": 10,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Moderate",
            "BP6_Very_Strong"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000437629.6",
          "gene_symbol": "SHLD2",
          "hgnc_id": 28773,
          "effects": [
            "5_prime_UTR_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.-275G>A",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "Hyperinsulinism-hyperammonemia syndrome,Inborn genetic diseases,not provided",
      "clinvar_classification": "Likely benign",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "LB:3",
      "phenotype_combined": "not provided|Hyperinsulinism-hyperammonemia syndrome|Inborn genetic diseases",
      "pathogenicity_classification_combined": "Likely benign",
      "custom_annotations": null
    }
  ],
  "message": null
}