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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-94030819-AC-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=94030819&ref=AC&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 94030819,
"ref": "AC",
"alt": "A",
"effect": "5_prime_UTR_variant",
"transcript": "NM_016341.4",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.-226delC",
"hgvs_p": null,
"transcript": "NM_016341.4",
"protein_id": "NP_057425.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2302,
"cds_start": -4,
"cds_end": null,
"cds_length": 6909,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 12481,
"mane_select": "ENST00000371380.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.-226delC",
"hgvs_p": null,
"transcript": "ENST00000371380.8",
"protein_id": "ENSP00000360431.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 2302,
"cds_start": -4,
"cds_end": null,
"cds_length": 6909,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 12481,
"mane_select": "NM_016341.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "n.-226delC",
"hgvs_p": null,
"transcript": "ENST00000675487.1",
"protein_id": "ENSP00000502340.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7588,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "n.-226delC",
"hgvs_p": null,
"transcript": "ENST00000685253.1",
"protein_id": "ENSP00000509405.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7113,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "n.-226delC",
"hgvs_p": null,
"transcript": "ENST00000686954.1",
"protein_id": "ENSP00000508416.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7303,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "n.105delC",
"hgvs_p": null,
"transcript": "ENST00000689233.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 11441,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "n.105delC",
"hgvs_p": null,
"transcript": "ENST00000689699.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4722,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.-226delC",
"hgvs_p": null,
"transcript": "NM_001288989.2",
"protein_id": "NP_001275918.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2286,
"cds_start": -4,
"cds_end": null,
"cds_length": 6861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 12433,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.-226delC",
"hgvs_p": null,
"transcript": "ENST00000692396.1",
"protein_id": "ENSP00000508605.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2286,
"cds_start": -4,
"cds_end": null,
"cds_length": 6861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9157,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.-226delC",
"hgvs_p": null,
"transcript": "ENST00000692286.1",
"protein_id": "ENSP00000509490.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2230,
"cds_start": -4,
"cds_end": null,
"cds_length": 6694,
"cdna_start": null,
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"cdna_length": 7024,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "n.-226delC",
"hgvs_p": null,
"transcript": "ENST00000675487.1",
"protein_id": "ENSP00000502340.1",
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"aa_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
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"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "n.-226delC",
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"transcript": "ENST00000685253.1",
"protein_id": "ENSP00000509405.1",
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"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
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"exon_count": 32,
"intron_rank": null,
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"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "n.-226delC",
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"transcript": "ENST00000686954.1",
"protein_id": "ENSP00000508416.1",
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"aa_start": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 2,
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"exon_count": 34,
"intron_rank": null,
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"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.-226delC",
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"transcript": "XM_006717885.5",
"protein_id": "XP_006717948.1",
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},
{
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"5_prime_UTR_variant"
],
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"gene_symbol": "PLCE1",
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"hgvs_c": "c.-226delC",
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"transcript": "XM_017016310.3",
"protein_id": "XP_016871799.1",
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},
{
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"strand": true,
"consequences": [
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],
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"exon_rank_end": null,
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"intron_rank": null,
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"gene_symbol": "PLCE1",
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"hgvs_c": "c.-226delC",
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"transcript": "XM_017016311.3",
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},
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],
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"gene_symbol": "PLCE1",
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"hgvs_c": "c.-226delC",
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"transcript": "XM_047425284.1",
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},
{
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"strand": true,
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],
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"intron_rank": null,
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"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.-226delC",
"hgvs_p": null,
"transcript": "XM_047425285.1",
"protein_id": "XP_047281241.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": null,
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"gene_symbol": "PLCE1",
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"hgvs_c": "c.-226delC",
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},
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],
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},
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],
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 2,
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"intron_rank": null,
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"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.-226delC",
"hgvs_p": null,
"transcript": "XM_047425288.1",
"protein_id": "XP_047281244.1",
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"feature": null
},
{
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"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
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"gene_symbol": "PLCE1",
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"hgvs_c": "c.-226delC",
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"transcript": "XM_047425289.1",
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