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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-94031056-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=94031056&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 94031056,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_016341.4",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "NM_016341.4",
"protein_id": "NP_057425.3",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2302,
"cds_start": 10,
"cds_end": null,
"cds_length": 6909,
"cdna_start": 702,
"cdna_end": null,
"cdna_length": 12481,
"mane_select": "ENST00000371380.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "ENST00000371380.8",
"protein_id": "ENSP00000360431.2",
"transcript_support_level": 1,
"aa_start": 4,
"aa_end": null,
"aa_length": 2302,
"cds_start": 10,
"cds_end": null,
"cds_length": 6909,
"cdna_start": 702,
"cdna_end": null,
"cdna_length": 12481,
"mane_select": "NM_016341.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "NM_001288989.2",
"protein_id": "NP_001275918.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2286,
"cds_start": 10,
"cds_end": null,
"cds_length": 6861,
"cdna_start": 702,
"cdna_end": null,
"cdna_length": 12433,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "ENST00000692396.1",
"protein_id": "ENSP00000508605.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2286,
"cds_start": 10,
"cds_end": null,
"cds_length": 6861,
"cdna_start": 599,
"cdna_end": null,
"cdna_length": 9157,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "ENST00000692286.1",
"protein_id": "ENSP00000509490.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2230,
"cds_start": 10,
"cds_end": null,
"cds_length": 6694,
"cdna_start": 340,
"cdna_end": null,
"cdna_length": 7024,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_006717885.5",
"protein_id": "XP_006717948.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2316,
"cds_start": 10,
"cds_end": null,
"cds_length": 6951,
"cdna_start": 702,
"cdna_end": null,
"cdna_length": 12523,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_017016310.3",
"protein_id": "XP_016871799.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2316,
"cds_start": 10,
"cds_end": null,
"cds_length": 6951,
"cdna_start": 749,
"cdna_end": null,
"cdna_length": 12570,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_017016311.3",
"protein_id": "XP_016871800.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2316,
"cds_start": 10,
"cds_end": null,
"cds_length": 6951,
"cdna_start": 702,
"cdna_end": null,
"cdna_length": 10857,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_047425284.1",
"protein_id": "XP_047281240.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2316,
"cds_start": 10,
"cds_end": null,
"cds_length": 6951,
"cdna_start": 428,
"cdna_end": null,
"cdna_length": 12249,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_047425285.1",
"protein_id": "XP_047281241.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2316,
"cds_start": 10,
"cds_end": null,
"cds_length": 6951,
"cdna_start": 2184,
"cdna_end": null,
"cdna_length": 14005,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_047425286.1",
"protein_id": "XP_047281242.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2316,
"cds_start": 10,
"cds_end": null,
"cds_length": 6951,
"cdna_start": 787,
"cdna_end": null,
"cdna_length": 12608,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_047425287.1",
"protein_id": "XP_047281243.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2316,
"cds_start": 10,
"cds_end": null,
"cds_length": 6951,
"cdna_start": 834,
"cdna_end": null,
"cdna_length": 12655,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_006717888.5",
"protein_id": "XP_006717951.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2315,
"cds_start": 10,
"cds_end": null,
"cds_length": 6948,
"cdna_start": 702,
"cdna_end": null,
"cdna_length": 12520,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_047425288.1",
"protein_id": "XP_047281244.1",
"transcript_support_level": null,
"aa_start": 4,
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"cds_start": 10,
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"cdna_start": 702,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_047425289.1",
"protein_id": "XP_047281245.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2302,
"cds_start": 10,
"cds_end": null,
"cds_length": 6909,
"cdna_start": 994,
"cdna_end": null,
"cdna_length": 12773,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_047425290.1",
"protein_id": "XP_047281246.1",
"transcript_support_level": null,
"aa_start": 4,
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"cdna_start": 749,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_047425291.1",
"protein_id": "XP_047281247.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2302,
"cds_start": 10,
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"cds_length": 6909,
"cdna_start": 428,
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"cdna_length": 12207,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_047425292.1",
"protein_id": "XP_047281248.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2302,
"cds_start": 10,
"cds_end": null,
"cds_length": 6909,
"cdna_start": 702,
"cdna_end": null,
"cdna_length": 10815,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_047425293.1",
"protein_id": "XP_047281249.1",
"transcript_support_level": null,
"aa_start": 4,
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"cdna_start": 428,
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"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_047425294.1",
"protein_id": "XP_047281250.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
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"cds_start": 10,
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"cdna_start": 749,
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"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_047425295.1",
"protein_id": "XP_047281251.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2300,
"cds_start": 10,
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"cds_length": 6903,
"cdna_start": 457,
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"cdna_length": 12230,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
"hgvs_p": "p.Glu4Lys",
"transcript": "XM_047425296.1",
"protein_id": "XP_047281252.1",
"transcript_support_level": null,
"aa_start": 4,
"aa_end": null,
"aa_length": 2300,
"cds_start": 10,
"cds_end": null,
"cds_length": 6903,
"cdna_start": 428,
"cdna_end": null,
"cdna_length": 12201,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PLCE1",
"gene_hgnc_id": 17175,
"hgvs_c": "c.10G>A",
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}
],
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}