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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-95037285-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=95037285&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 95037285,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_000770.3",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1316G>A",
"hgvs_p": "p.Gly439Glu",
"transcript": "NM_000770.3",
"protein_id": "NP_000761.3",
"transcript_support_level": null,
"aa_start": 439,
"aa_end": null,
"aa_length": 490,
"cds_start": 1316,
"cds_end": null,
"cds_length": 1473,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000371270.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000770.3"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1316G>A",
"hgvs_p": "p.Gly439Glu",
"transcript": "ENST00000371270.6",
"protein_id": "ENSP00000360317.3",
"transcript_support_level": 1,
"aa_start": 439,
"aa_end": null,
"aa_length": 490,
"cds_start": 1316,
"cds_end": null,
"cds_length": 1473,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_000770.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000371270.6"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1397G>A",
"hgvs_p": "p.Gly466Glu",
"transcript": "ENST00000854622.1",
"protein_id": "ENSP00000524681.1",
"transcript_support_level": null,
"aa_start": 466,
"aa_end": null,
"aa_length": 517,
"cds_start": 1397,
"cds_end": null,
"cds_length": 1554,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854622.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1352G>A",
"hgvs_p": "p.Gly451Glu",
"transcript": "ENST00000854631.1",
"protein_id": "ENSP00000524690.1",
"transcript_support_level": null,
"aa_start": 451,
"aa_end": null,
"aa_length": 502,
"cds_start": 1352,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854631.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1337G>A",
"hgvs_p": "p.Gly446Glu",
"transcript": "ENST00000854618.1",
"protein_id": "ENSP00000524677.1",
"transcript_support_level": null,
"aa_start": 446,
"aa_end": null,
"aa_length": 497,
"cds_start": 1337,
"cds_end": null,
"cds_length": 1494,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854618.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1310G>A",
"hgvs_p": "p.Gly437Glu",
"transcript": "ENST00000854621.1",
"protein_id": "ENSP00000524680.1",
"transcript_support_level": null,
"aa_start": 437,
"aa_end": null,
"aa_length": 488,
"cds_start": 1310,
"cds_end": null,
"cds_length": 1467,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854621.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1310G>A",
"hgvs_p": "p.Gly437Glu",
"transcript": "ENST00000854623.1",
"protein_id": "ENSP00000524682.1",
"transcript_support_level": null,
"aa_start": 437,
"aa_end": null,
"aa_length": 488,
"cds_start": 1310,
"cds_end": null,
"cds_length": 1467,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854623.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1298G>A",
"hgvs_p": "p.Gly433Glu",
"transcript": "ENST00000854627.1",
"protein_id": "ENSP00000524686.1",
"transcript_support_level": null,
"aa_start": 433,
"aa_end": null,
"aa_length": 484,
"cds_start": 1298,
"cds_end": null,
"cds_length": 1455,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854627.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1289G>A",
"hgvs_p": "p.Gly430Glu",
"transcript": "ENST00000854634.1",
"protein_id": "ENSP00000524693.1",
"transcript_support_level": null,
"aa_start": 430,
"aa_end": null,
"aa_length": 481,
"cds_start": 1289,
"cds_end": null,
"cds_length": 1446,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854634.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1178G>A",
"hgvs_p": "p.Gly393Glu",
"transcript": "ENST00000854626.1",
"protein_id": "ENSP00000524685.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 444,
"cds_start": 1178,
"cds_end": null,
"cds_length": 1335,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854626.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1175G>A",
"hgvs_p": "p.Gly392Glu",
"transcript": "ENST00000854619.1",
"protein_id": "ENSP00000524678.1",
"transcript_support_level": null,
"aa_start": 392,
"aa_end": null,
"aa_length": 443,
"cds_start": 1175,
"cds_end": null,
"cds_length": 1332,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854619.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1166G>A",
"hgvs_p": "p.Gly389Glu",
"transcript": "ENST00000854617.1",
"protein_id": "ENSP00000524676.1",
"transcript_support_level": null,
"aa_start": 389,
"aa_end": null,
"aa_length": 440,
"cds_start": 1166,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854617.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1115G>A",
"hgvs_p": "p.Gly372Glu",
"transcript": "ENST00000854629.1",
"protein_id": "ENSP00000524688.1",
"transcript_support_level": null,
"aa_start": 372,
"aa_end": null,
"aa_length": 423,
"cds_start": 1115,
"cds_end": null,
"cds_length": 1272,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854629.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1106G>A",
"hgvs_p": "p.Gly369Glu",
"transcript": "NM_001198853.1",
"protein_id": "NP_001185782.1",
"transcript_support_level": null,
"aa_start": 369,
"aa_end": null,
"aa_length": 420,
"cds_start": 1106,
"cds_end": null,
"cds_length": 1263,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001198853.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1106G>A",
"hgvs_p": "p.Gly369Glu",
"transcript": "NM_001198855.1",
"protein_id": "NP_001185784.1",
"transcript_support_level": null,
"aa_start": 369,
"aa_end": null,
"aa_length": 420,
"cds_start": 1106,
"cds_end": null,
"cds_length": 1263,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001198855.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1106G>A",
"hgvs_p": "p.Gly369Glu",
"transcript": "ENST00000623108.3",
"protein_id": "ENSP00000485110.1",
"transcript_support_level": 2,
"aa_start": 369,
"aa_end": null,
"aa_length": 420,
"cds_start": 1106,
"cds_end": null,
"cds_length": 1263,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000623108.3"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1010G>A",
"hgvs_p": "p.Gly337Glu",
"transcript": "NM_001198854.1",
"protein_id": "NP_001185783.1",
"transcript_support_level": null,
"aa_start": 337,
"aa_end": null,
"aa_length": 388,
"cds_start": 1010,
"cds_end": null,
"cds_length": 1167,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001198854.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1010G>A",
"hgvs_p": "p.Gly337Glu",
"transcript": "ENST00000535898.5",
"protein_id": "ENSP00000445062.1",
"transcript_support_level": 2,
"aa_start": 337,
"aa_end": null,
"aa_length": 388,
"cds_start": 1010,
"cds_end": null,
"cds_length": 1167,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000535898.5"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.986G>A",
"hgvs_p": "p.Gly329Glu",
"transcript": "ENST00000854625.1",
"protein_id": "ENSP00000524684.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 380,
"cds_start": 986,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854625.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.986G>A",
"hgvs_p": "p.Gly329Glu",
"transcript": "ENST00000854628.1",
"protein_id": "ENSP00000524687.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 380,
"cds_start": 986,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854628.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.932G>A",
"hgvs_p": "p.Gly311Glu",
"transcript": "ENST00000854633.1",
"protein_id": "ENSP00000524692.1",
"transcript_support_level": null,
"aa_start": 311,
"aa_end": null,
"aa_length": 362,
"cds_start": 932,
"cds_end": null,
"cds_length": 1089,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854633.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.842G>A",
"hgvs_p": "p.Gly281Glu",
"transcript": "ENST00000854624.1",
"protein_id": "ENSP00000524683.1",
"transcript_support_level": null,
"aa_start": 281,
"aa_end": null,
"aa_length": 332,
"cds_start": 842,
"cds_end": null,
"cds_length": 999,
"cdna_start": null,
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{
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"pathogenic_score": 2,
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"verdict": "Uncertain_significance",
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],
"clinvar_disease": "not specified",
"clinvar_classification": "Uncertain significance",
"clinvar_review_status": "criteria provided, single submitter",
"clinvar_submissions_summary": "US:1",
"phenotype_combined": "not specified",
"pathogenicity_classification_combined": "Uncertain significance",
"custom_annotations": null
}
],
"message": null
}