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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-95042958-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=95042958&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 95042958,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_000770.3",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1081C>T",
"hgvs_p": "p.Leu361Phe",
"transcript": "NM_000770.3",
"protein_id": "NP_000761.3",
"transcript_support_level": null,
"aa_start": 361,
"aa_end": null,
"aa_length": 490,
"cds_start": 1081,
"cds_end": null,
"cds_length": 1473,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000371270.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000770.3"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1081C>T",
"hgvs_p": "p.Leu361Phe",
"transcript": "ENST00000371270.6",
"protein_id": "ENSP00000360317.3",
"transcript_support_level": 1,
"aa_start": 361,
"aa_end": null,
"aa_length": 490,
"cds_start": 1081,
"cds_end": null,
"cds_length": 1473,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_000770.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000371270.6"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1162C>T",
"hgvs_p": "p.Leu388Phe",
"transcript": "ENST00000854622.1",
"protein_id": "ENSP00000524681.1",
"transcript_support_level": null,
"aa_start": 388,
"aa_end": null,
"aa_length": 517,
"cds_start": 1162,
"cds_end": null,
"cds_length": 1554,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854622.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1117C>T",
"hgvs_p": "p.Leu373Phe",
"transcript": "ENST00000854631.1",
"protein_id": "ENSP00000524690.1",
"transcript_support_level": null,
"aa_start": 373,
"aa_end": null,
"aa_length": 502,
"cds_start": 1117,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854631.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1102C>T",
"hgvs_p": "p.Leu368Phe",
"transcript": "ENST00000854618.1",
"protein_id": "ENSP00000524677.1",
"transcript_support_level": null,
"aa_start": 368,
"aa_end": null,
"aa_length": 497,
"cds_start": 1102,
"cds_end": null,
"cds_length": 1494,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854618.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1075C>T",
"hgvs_p": "p.Leu359Phe",
"transcript": "ENST00000854621.1",
"protein_id": "ENSP00000524680.1",
"transcript_support_level": null,
"aa_start": 359,
"aa_end": null,
"aa_length": 488,
"cds_start": 1075,
"cds_end": null,
"cds_length": 1467,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854621.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1075C>T",
"hgvs_p": "p.Leu359Phe",
"transcript": "ENST00000854623.1",
"protein_id": "ENSP00000524682.1",
"transcript_support_level": null,
"aa_start": 359,
"aa_end": null,
"aa_length": 488,
"cds_start": 1075,
"cds_end": null,
"cds_length": 1467,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854623.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1081C>T",
"hgvs_p": "p.Leu361Phe",
"transcript": "ENST00000854627.1",
"protein_id": "ENSP00000524686.1",
"transcript_support_level": null,
"aa_start": 361,
"aa_end": null,
"aa_length": 484,
"cds_start": 1081,
"cds_end": null,
"cds_length": 1455,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854627.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.1081C>T",
"hgvs_p": "p.Leu361Phe",
"transcript": "ENST00000854634.1",
"protein_id": "ENSP00000524693.1",
"transcript_support_level": null,
"aa_start": 361,
"aa_end": null,
"aa_length": 481,
"cds_start": 1081,
"cds_end": null,
"cds_length": 1446,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854634.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.943C>T",
"hgvs_p": "p.Leu315Phe",
"transcript": "ENST00000854626.1",
"protein_id": "ENSP00000524685.1",
"transcript_support_level": null,
"aa_start": 315,
"aa_end": null,
"aa_length": 444,
"cds_start": 943,
"cds_end": null,
"cds_length": 1335,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854626.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.940C>T",
"hgvs_p": "p.Leu314Phe",
"transcript": "ENST00000854619.1",
"protein_id": "ENSP00000524678.1",
"transcript_support_level": null,
"aa_start": 314,
"aa_end": null,
"aa_length": 443,
"cds_start": 940,
"cds_end": null,
"cds_length": 1332,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854619.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.931C>T",
"hgvs_p": "p.Leu311Phe",
"transcript": "ENST00000854617.1",
"protein_id": "ENSP00000524676.1",
"transcript_support_level": null,
"aa_start": 311,
"aa_end": null,
"aa_length": 440,
"cds_start": 931,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854617.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.880C>T",
"hgvs_p": "p.Leu294Phe",
"transcript": "ENST00000854629.1",
"protein_id": "ENSP00000524688.1",
"transcript_support_level": null,
"aa_start": 294,
"aa_end": null,
"aa_length": 423,
"cds_start": 880,
"cds_end": null,
"cds_length": 1272,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854629.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.871C>T",
"hgvs_p": "p.Leu291Phe",
"transcript": "NM_001198853.1",
"protein_id": "NP_001185782.1",
"transcript_support_level": null,
"aa_start": 291,
"aa_end": null,
"aa_length": 420,
"cds_start": 871,
"cds_end": null,
"cds_length": 1263,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001198853.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.871C>T",
"hgvs_p": "p.Leu291Phe",
"transcript": "NM_001198855.1",
"protein_id": "NP_001185784.1",
"transcript_support_level": null,
"aa_start": 291,
"aa_end": null,
"aa_length": 420,
"cds_start": 871,
"cds_end": null,
"cds_length": 1263,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001198855.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.871C>T",
"hgvs_p": "p.Leu291Phe",
"transcript": "ENST00000623108.3",
"protein_id": "ENSP00000485110.1",
"transcript_support_level": 2,
"aa_start": 291,
"aa_end": null,
"aa_length": 420,
"cds_start": 871,
"cds_end": null,
"cds_length": 1263,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000623108.3"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.775C>T",
"hgvs_p": "p.Leu259Phe",
"transcript": "NM_001198854.1",
"protein_id": "NP_001185783.1",
"transcript_support_level": null,
"aa_start": 259,
"aa_end": null,
"aa_length": 388,
"cds_start": 775,
"cds_end": null,
"cds_length": 1167,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001198854.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.775C>T",
"hgvs_p": "p.Leu259Phe",
"transcript": "ENST00000535898.5",
"protein_id": "ENSP00000445062.1",
"transcript_support_level": 2,
"aa_start": 259,
"aa_end": null,
"aa_length": 388,
"cds_start": 775,
"cds_end": null,
"cds_length": 1167,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000535898.5"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.697C>T",
"hgvs_p": "p.Leu233Phe",
"transcript": "ENST00000854633.1",
"protein_id": "ENSP00000524692.1",
"transcript_support_level": null,
"aa_start": 233,
"aa_end": null,
"aa_length": 362,
"cds_start": 697,
"cds_end": null,
"cds_length": 1089,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854633.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.607C>T",
"hgvs_p": "p.Leu203Phe",
"transcript": "ENST00000854624.1",
"protein_id": "ENSP00000524683.1",
"transcript_support_level": null,
"aa_start": 203,
"aa_end": null,
"aa_length": 332,
"cds_start": 607,
"cds_end": null,
"cds_length": 999,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854624.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.823C>T",
"hgvs_p": "p.Leu275Phe",
"transcript": "ENST00000628935.1",
"protein_id": "ENSP00000487145.1",
"transcript_support_level": 5,
"aa_start": 275,
"aa_end": null,
"aa_length": 307,
"cds_start": 823,
"cds_end": null,
"cds_length": 924,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000628935.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYP2C8",
"gene_hgnc_id": 2622,
"hgvs_c": "c.451C>T",
"hgvs_p": "p.Leu151Phe",
"transcript": "ENST00000854630.1",
"protein_id": "ENSP00000524689.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 280,
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}