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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-95683128-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=95683128&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 95683128,
"ref": "A",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_015631.6",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1271T>G",
"hgvs_p": "p.Val424Gly",
"transcript": "NM_015631.6",
"protein_id": "NP_056446.4",
"transcript_support_level": null,
"aa_start": 424,
"aa_end": null,
"aa_length": 607,
"cds_start": 1271,
"cds_end": null,
"cds_length": 1824,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000371217.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015631.6"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1271T>G",
"hgvs_p": "p.Val424Gly",
"transcript": "ENST00000371217.10",
"protein_id": "ENSP00000360261.5",
"transcript_support_level": 1,
"aa_start": 424,
"aa_end": null,
"aa_length": 607,
"cds_start": 1271,
"cds_end": null,
"cds_length": 1824,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_015631.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000371217.10"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1325T>G",
"hgvs_p": "p.Val442Gly",
"transcript": "ENST00000265993.13",
"protein_id": "ENSP00000265993.9",
"transcript_support_level": 1,
"aa_start": 442,
"aa_end": null,
"aa_length": 625,
"cds_start": 1325,
"cds_end": null,
"cds_length": 1878,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000265993.13"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1310T>G",
"hgvs_p": "p.Val437Gly",
"transcript": "ENST00000614499.5",
"protein_id": "ENSP00000483364.2",
"transcript_support_level": 1,
"aa_start": 437,
"aa_end": null,
"aa_length": 620,
"cds_start": 1310,
"cds_end": null,
"cds_length": 1863,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000614499.5"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.827T>G",
"hgvs_p": "p.Val276Gly",
"transcript": "ENST00000430368.6",
"protein_id": "ENSP00000387567.1",
"transcript_support_level": 2,
"aa_start": 276,
"aa_end": null,
"aa_length": 459,
"cds_start": 827,
"cds_end": null,
"cds_length": 1380,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000430368.6"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1292T>G",
"hgvs_p": "p.Val431Gly",
"transcript": "ENST00000898873.1",
"protein_id": "ENSP00000568932.1",
"transcript_support_level": null,
"aa_start": 431,
"aa_end": null,
"aa_length": 614,
"cds_start": 1292,
"cds_end": null,
"cds_length": 1845,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898873.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1265T>G",
"hgvs_p": "p.Val422Gly",
"transcript": "ENST00000898868.1",
"protein_id": "ENSP00000568927.1",
"transcript_support_level": null,
"aa_start": 422,
"aa_end": null,
"aa_length": 605,
"cds_start": 1265,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898868.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1262T>G",
"hgvs_p": "p.Val421Gly",
"transcript": "ENST00000939774.1",
"protein_id": "ENSP00000609833.1",
"transcript_support_level": null,
"aa_start": 421,
"aa_end": null,
"aa_length": 604,
"cds_start": 1262,
"cds_end": null,
"cds_length": 1815,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939774.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1250T>G",
"hgvs_p": "p.Val417Gly",
"transcript": "ENST00000898870.1",
"protein_id": "ENSP00000568929.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 600,
"cds_start": 1250,
"cds_end": null,
"cds_length": 1803,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898870.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1250T>G",
"hgvs_p": "p.Val417Gly",
"transcript": "ENST00000956556.1",
"protein_id": "ENSP00000626615.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 600,
"cds_start": 1250,
"cds_end": null,
"cds_length": 1803,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956556.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1190T>G",
"hgvs_p": "p.Val397Gly",
"transcript": "ENST00000898866.1",
"protein_id": "ENSP00000568925.1",
"transcript_support_level": null,
"aa_start": 397,
"aa_end": null,
"aa_length": 580,
"cds_start": 1190,
"cds_end": null,
"cds_length": 1743,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898866.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1175T>G",
"hgvs_p": "p.Val392Gly",
"transcript": "NM_001410982.1",
"protein_id": "NP_001397911.1",
"transcript_support_level": null,
"aa_start": 392,
"aa_end": null,
"aa_length": 575,
"cds_start": 1175,
"cds_end": null,
"cds_length": 1728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001410982.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1175T>G",
"hgvs_p": "p.Val392Gly",
"transcript": "ENST00000680144.1",
"protein_id": "ENSP00000506398.1",
"transcript_support_level": null,
"aa_start": 392,
"aa_end": null,
"aa_length": 575,
"cds_start": 1175,
"cds_end": null,
"cds_length": 1728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000680144.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1169T>G",
"hgvs_p": "p.Val390Gly",
"transcript": "ENST00000939775.1",
"protein_id": "ENSP00000609834.1",
"transcript_support_level": null,
"aa_start": 390,
"aa_end": null,
"aa_length": 573,
"cds_start": 1169,
"cds_end": null,
"cds_length": 1722,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939775.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1256T>G",
"hgvs_p": "p.Val419Gly",
"transcript": "ENST00000956559.1",
"protein_id": "ENSP00000626618.1",
"transcript_support_level": null,
"aa_start": 419,
"aa_end": null,
"aa_length": 573,
"cds_start": 1256,
"cds_end": null,
"cds_length": 1722,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956559.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1271T>G",
"hgvs_p": "p.Val424Gly",
"transcript": "ENST00000898869.1",
"protein_id": "ENSP00000568928.1",
"transcript_support_level": null,
"aa_start": 424,
"aa_end": null,
"aa_length": 561,
"cds_start": 1271,
"cds_end": null,
"cds_length": 1686,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898869.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1064T>G",
"hgvs_p": "p.Val355Gly",
"transcript": "ENST00000939777.1",
"protein_id": "ENSP00000609836.1",
"transcript_support_level": null,
"aa_start": 355,
"aa_end": null,
"aa_length": 538,
"cds_start": 1064,
"cds_end": null,
"cds_length": 1617,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939777.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1190T>G",
"hgvs_p": "p.Val397Gly",
"transcript": "ENST00000956557.1",
"protein_id": "ENSP00000626616.1",
"transcript_support_level": null,
"aa_start": 397,
"aa_end": null,
"aa_length": 534,
"cds_start": 1190,
"cds_end": null,
"cds_length": 1605,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956557.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1034T>G",
"hgvs_p": "p.Val345Gly",
"transcript": "ENST00000898867.1",
"protein_id": "ENSP00000568926.1",
"transcript_support_level": null,
"aa_start": 345,
"aa_end": null,
"aa_length": 528,
"cds_start": 1034,
"cds_end": null,
"cds_length": 1587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898867.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1028T>G",
"hgvs_p": "p.Val343Gly",
"transcript": "ENST00000939776.1",
"protein_id": "ENSP00000609835.1",
"transcript_support_level": null,
"aa_start": 343,
"aa_end": null,
"aa_length": 526,
"cds_start": 1028,
"cds_end": null,
"cds_length": 1581,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939776.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.1019T>G",
"hgvs_p": "p.Val340Gly",
"transcript": "ENST00000680709.1",
"protein_id": "ENSP00000505830.1",
"transcript_support_level": null,
"aa_start": 340,
"aa_end": null,
"aa_length": 523,
"cds_start": 1019,
"cds_end": null,
"cds_length": 1572,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000680709.1"
},
{
"aa_ref": "V",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCTN3",
"gene_hgnc_id": 24519,
"hgvs_c": "c.953T>G",
"hgvs_p": "p.Val318Gly",
"transcript": "ENST00000898871.1",
"protein_id": "ENSP00000568930.1",
"transcript_support_level": null,
"aa_start": 318,
"aa_end": null,
"aa_length": 501,
"cds_start": 953,
"cds_end": null,
"cds_length": 1506,
"cdna_start": null,
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}
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}