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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-95866183-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=95866183&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 95866183,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_001440932.1",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1333G>T",
"hgvs_p": "p.Gly445Cys",
"transcript": "NM_001776.6",
"protein_id": "NP_001767.3",
"transcript_support_level": null,
"aa_start": 445,
"aa_end": null,
"aa_length": 510,
"cds_start": 1333,
"cds_end": null,
"cds_length": 1533,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000371205.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001776.6"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1333G>T",
"hgvs_p": "p.Gly445Cys",
"transcript": "ENST00000371205.5",
"protein_id": "ENSP00000360248.4",
"transcript_support_level": 1,
"aa_start": 445,
"aa_end": null,
"aa_length": 510,
"cds_start": 1333,
"cds_end": null,
"cds_length": 1533,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001776.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000371205.5"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1354G>T",
"hgvs_p": "p.Gly452Cys",
"transcript": "ENST00000453258.6",
"protein_id": "ENSP00000390955.2",
"transcript_support_level": 1,
"aa_start": 452,
"aa_end": null,
"aa_length": 517,
"cds_start": 1354,
"cds_end": null,
"cds_length": 1554,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000453258.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "n.*908G>T",
"hgvs_p": null,
"transcript": "ENST00000635076.1",
"protein_id": "ENSP00000489250.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000635076.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "n.*908G>T",
"hgvs_p": null,
"transcript": "ENST00000635076.1",
"protein_id": "ENSP00000489250.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000635076.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ENSG00000270099",
"gene_hgnc_id": null,
"hgvs_c": "n.171+1322G>T",
"hgvs_p": null,
"transcript": "ENST00000491114.1",
"protein_id": "ENSP00000473305.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000491114.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1411G>T",
"hgvs_p": "p.Gly471Cys",
"transcript": "NM_001440932.1",
"protein_id": "NP_001427861.1",
"transcript_support_level": null,
"aa_start": 471,
"aa_end": null,
"aa_length": 536,
"cds_start": 1411,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440932.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1369G>T",
"hgvs_p": "p.Gly457Cys",
"transcript": "NM_001164178.1",
"protein_id": "NP_001157650.1",
"transcript_support_level": null,
"aa_start": 457,
"aa_end": null,
"aa_length": 522,
"cds_start": 1369,
"cds_end": null,
"cds_length": 1569,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001164178.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1369G>T",
"hgvs_p": "p.Gly457Cys",
"transcript": "ENST00000371207.8",
"protein_id": "ENSP00000360250.3",
"transcript_support_level": 2,
"aa_start": 457,
"aa_end": null,
"aa_length": 522,
"cds_start": 1369,
"cds_end": null,
"cds_length": 1569,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000371207.8"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1354G>T",
"hgvs_p": "p.Gly452Cys",
"transcript": "NM_001098175.2",
"protein_id": "NP_001091645.1",
"transcript_support_level": null,
"aa_start": 452,
"aa_end": null,
"aa_length": 517,
"cds_start": 1354,
"cds_end": null,
"cds_length": 1554,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001098175.2"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1354G>T",
"hgvs_p": "p.Gly452Cys",
"transcript": "NM_001440933.1",
"protein_id": "NP_001427862.1",
"transcript_support_level": null,
"aa_start": 452,
"aa_end": null,
"aa_length": 517,
"cds_start": 1354,
"cds_end": null,
"cds_length": 1554,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440933.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1354G>T",
"hgvs_p": "p.Gly452Cys",
"transcript": "NM_001440934.1",
"protein_id": "NP_001427863.1",
"transcript_support_level": null,
"aa_start": 452,
"aa_end": null,
"aa_length": 517,
"cds_start": 1354,
"cds_end": null,
"cds_length": 1554,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440934.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1246G>T",
"hgvs_p": "p.Gly416Cys",
"transcript": "NM_001440936.1",
"protein_id": "NP_001427865.1",
"transcript_support_level": null,
"aa_start": 416,
"aa_end": null,
"aa_length": 481,
"cds_start": 1246,
"cds_end": null,
"cds_length": 1446,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440936.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1222G>T",
"hgvs_p": "p.Gly408Cys",
"transcript": "ENST00000859526.1",
"protein_id": "ENSP00000529585.1",
"transcript_support_level": null,
"aa_start": 408,
"aa_end": null,
"aa_length": 473,
"cds_start": 1222,
"cds_end": null,
"cds_length": 1422,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859526.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1210G>T",
"hgvs_p": "p.Gly404Cys",
"transcript": "NM_001164179.2",
"protein_id": "NP_001157651.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 469,
"cds_start": 1210,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001164179.2"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1210G>T",
"hgvs_p": "p.Gly404Cys",
"transcript": "ENST00000859524.1",
"protein_id": "ENSP00000529583.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 469,
"cds_start": 1210,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859524.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1207G>T",
"hgvs_p": "p.Gly403Cys",
"transcript": "ENST00000859525.1",
"protein_id": "ENSP00000529584.1",
"transcript_support_level": null,
"aa_start": 403,
"aa_end": null,
"aa_length": 468,
"cds_start": 1207,
"cds_end": null,
"cds_length": 1407,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859525.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1195G>T",
"hgvs_p": "p.Gly399Cys",
"transcript": "ENST00000953039.1",
"protein_id": "ENSP00000623098.1",
"transcript_support_level": null,
"aa_start": 399,
"aa_end": null,
"aa_length": 464,
"cds_start": 1195,
"cds_end": null,
"cds_length": 1395,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953039.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1132G>T",
"hgvs_p": "p.Gly378Cys",
"transcript": "ENST00000953041.1",
"protein_id": "ENSP00000623100.1",
"transcript_support_level": null,
"aa_start": 378,
"aa_end": null,
"aa_length": 443,
"cds_start": 1132,
"cds_end": null,
"cds_length": 1332,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953041.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1099G>T",
"hgvs_p": "p.Gly367Cys",
"transcript": "ENST00000953040.1",
"protein_id": "ENSP00000623099.1",
"transcript_support_level": null,
"aa_start": 367,
"aa_end": null,
"aa_length": 432,
"cds_start": 1099,
"cds_end": null,
"cds_length": 1299,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953040.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1093G>T",
"hgvs_p": "p.Gly365Cys",
"transcript": "ENST00000859523.1",
"protein_id": "ENSP00000529582.1",
"transcript_support_level": null,
"aa_start": 365,
"aa_end": null,
"aa_length": 430,
"cds_start": 1093,
"cds_end": null,
"cds_length": 1293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859523.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENTPD1",
"gene_hgnc_id": 3363,
"hgvs_c": "c.1009G>T",
"hgvs_p": "p.Gly337Cys",
"transcript": "NM_001164181.1",
"protein_id": "NP_001157653.1",
"transcript_support_level": null,
"aa_start": 337,
"aa_end": null,
"aa_length": 402,
"cds_start": 1009,
"cds_end": null,
"cds_length": 1209,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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{
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{
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}
],
"message": null
}