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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 10-96013834-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=96013834&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "10",
      "pos": 96013834,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_001349008.3",
      "consequences": [
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 29,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.3473C>T",
          "hgvs_p": "p.Thr1158Ile",
          "transcript": "NM_001349008.3",
          "protein_id": "NP_001335937.1",
          "transcript_support_level": null,
          "aa_start": 1158,
          "aa_end": null,
          "aa_length": 1437,
          "cds_start": 3473,
          "cds_end": null,
          "cds_length": 4314,
          "cdna_start": 3579,
          "cdna_end": null,
          "cdna_length": 6157,
          "mane_select": "ENST00000646931.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001349008.3"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 29,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.3473C>T",
          "hgvs_p": "p.Thr1158Ile",
          "transcript": "ENST00000646931.3",
          "protein_id": "ENSP00000496666.2",
          "transcript_support_level": null,
          "aa_start": 1158,
          "aa_end": null,
          "aa_length": 1437,
          "cds_start": 3473,
          "cds_end": null,
          "cds_length": 4314,
          "cdna_start": 3579,
          "cdna_end": null,
          "cdna_length": 6157,
          "mane_select": "NM_001349008.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000646931.3"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "n.529C>T",
          "hgvs_p": null,
          "transcript": "ENST00000344386.4",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1809,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000344386.4"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.2573C>T",
          "hgvs_p": "p.Thr858Ile",
          "transcript": "ENST00000636965.1",
          "protein_id": "ENSP00000490447.1",
          "transcript_support_level": 5,
          "aa_start": 858,
          "aa_end": null,
          "aa_length": 1058,
          "cds_start": 2573,
          "cds_end": null,
          "cds_length": 3177,
          "cdna_start": 2643,
          "cdna_end": null,
          "cdna_length": 3247,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000636965.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.365C>T",
          "hgvs_p": "p.Thr122Ile",
          "transcript": "NM_001159747.2",
          "protein_id": "NP_001153219.1",
          "transcript_support_level": null,
          "aa_start": 122,
          "aa_end": null,
          "aa_length": 401,
          "cds_start": 365,
          "cds_end": null,
          "cds_length": 1206,
          "cdna_start": 921,
          "cdna_end": null,
          "cdna_length": 3499,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001159747.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.365C>T",
          "hgvs_p": "p.Thr122Ile",
          "transcript": "NM_001001732.4",
          "protein_id": "NP_001001732.2",
          "transcript_support_level": null,
          "aa_start": 122,
          "aa_end": null,
          "aa_length": 322,
          "cds_start": 365,
          "cds_end": null,
          "cds_length": 969,
          "cdna_start": 888,
          "cdna_end": null,
          "cdna_length": 3229,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001001732.4"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 29,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.3473C>T",
          "hgvs_p": "p.Thr1158Ile",
          "transcript": "XM_024447995.2",
          "protein_id": "XP_024303763.1",
          "transcript_support_level": null,
          "aa_start": 1158,
          "aa_end": null,
          "aa_length": 1437,
          "cds_start": 3473,
          "cds_end": null,
          "cds_length": 4314,
          "cdna_start": 3587,
          "cdna_end": null,
          "cdna_length": 6165,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024447995.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 30,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.3449C>T",
          "hgvs_p": "p.Thr1150Ile",
          "transcript": "XM_024447996.2",
          "protein_id": "XP_024303764.1",
          "transcript_support_level": null,
          "aa_start": 1150,
          "aa_end": null,
          "aa_length": 1429,
          "cds_start": 3449,
          "cds_end": null,
          "cds_length": 4290,
          "cdna_start": 3635,
          "cdna_end": null,
          "cdna_length": 6213,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024447996.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 29,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.3473C>T",
          "hgvs_p": "p.Thr1158Ile",
          "transcript": "XM_024447998.2",
          "protein_id": "XP_024303766.1",
          "transcript_support_level": null,
          "aa_start": 1158,
          "aa_end": null,
          "aa_length": 1399,
          "cds_start": 3473,
          "cds_end": null,
          "cds_length": 4200,
          "cdna_start": 3579,
          "cdna_end": null,
          "cdna_length": 6043,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024447998.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.3344C>T",
          "hgvs_p": "p.Thr1115Ile",
          "transcript": "XM_024447999.2",
          "protein_id": "XP_024303767.1",
          "transcript_support_level": null,
          "aa_start": 1115,
          "aa_end": null,
          "aa_length": 1394,
          "cds_start": 3344,
          "cds_end": null,
          "cds_length": 4185,
          "cdna_start": 3450,
          "cdna_end": null,
          "cdna_length": 6028,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024447999.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.3290C>T",
          "hgvs_p": "p.Thr1097Ile",
          "transcript": "XM_024448001.2",
          "protein_id": "XP_024303769.1",
          "transcript_support_level": null,
          "aa_start": 1097,
          "aa_end": null,
          "aa_length": 1376,
          "cds_start": 3290,
          "cds_end": null,
          "cds_length": 4131,
          "cdna_start": 3396,
          "cdna_end": null,
          "cdna_length": 5974,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024448001.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 29,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.3473C>T",
          "hgvs_p": "p.Thr1158Ile",
          "transcript": "XM_024448002.2",
          "protein_id": "XP_024303770.1",
          "transcript_support_level": null,
          "aa_start": 1158,
          "aa_end": null,
          "aa_length": 1303,
          "cds_start": 3473,
          "cds_end": null,
          "cds_length": 3912,
          "cdna_start": 3579,
          "cdna_end": null,
          "cdna_length": 4118,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024448002.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 29,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.3473C>T",
          "hgvs_p": "p.Thr1158Ile",
          "transcript": "XM_024448003.2",
          "protein_id": "XP_024303771.1",
          "transcript_support_level": null,
          "aa_start": 1158,
          "aa_end": null,
          "aa_length": 1297,
          "cds_start": 3473,
          "cds_end": null,
          "cds_length": 3894,
          "cdna_start": 3579,
          "cdna_end": null,
          "cdna_length": 4703,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024448003.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 26,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.2996C>T",
          "hgvs_p": "p.Thr999Ile",
          "transcript": "XM_024448004.2",
          "protein_id": "XP_024303772.1",
          "transcript_support_level": null,
          "aa_start": 999,
          "aa_end": null,
          "aa_length": 1278,
          "cds_start": 2996,
          "cds_end": null,
          "cds_length": 3837,
          "cdna_start": 3102,
          "cdna_end": null,
          "cdna_length": 5680,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024448004.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 25,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.2912C>T",
          "hgvs_p": "p.Thr971Ile",
          "transcript": "XM_011539789.4",
          "protein_id": "XP_011538091.2",
          "transcript_support_level": null,
          "aa_start": 971,
          "aa_end": null,
          "aa_length": 1250,
          "cds_start": 2912,
          "cds_end": null,
          "cds_length": 3753,
          "cdna_start": 3018,
          "cdna_end": null,
          "cdna_length": 5596,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011539789.4"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.2642C>T",
          "hgvs_p": "p.Thr881Ile",
          "transcript": "XM_047425225.1",
          "protein_id": "XP_047281181.1",
          "transcript_support_level": null,
          "aa_start": 881,
          "aa_end": null,
          "aa_length": 1160,
          "cds_start": 2642,
          "cds_end": null,
          "cds_length": 3483,
          "cdna_start": 2760,
          "cdna_end": null,
          "cdna_length": 5338,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047425225.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.2465C>T",
          "hgvs_p": "p.Thr822Ile",
          "transcript": "XM_047425226.1",
          "protein_id": "XP_047281182.1",
          "transcript_support_level": null,
          "aa_start": 822,
          "aa_end": null,
          "aa_length": 1101,
          "cds_start": 2465,
          "cds_end": null,
          "cds_length": 3306,
          "cdna_start": 2563,
          "cdna_end": null,
          "cdna_length": 5141,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047425226.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.2351C>T",
          "hgvs_p": "p.Thr784Ile",
          "transcript": "XM_047425227.1",
          "protein_id": "XP_047281183.1",
          "transcript_support_level": null,
          "aa_start": 784,
          "aa_end": null,
          "aa_length": 1063,
          "cds_start": 2351,
          "cds_end": null,
          "cds_length": 3192,
          "cdna_start": 2627,
          "cdna_end": null,
          "cdna_length": 5205,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047425227.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 26,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "c.3045+3911C>T",
          "hgvs_p": null,
          "transcript": "XM_024448005.2",
          "protein_id": "XP_024303773.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1156,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 3471,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 5314,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024448005.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CC2D2B",
          "gene_hgnc_id": 31666,
          "hgvs_c": "n.576C>T",
          "hgvs_p": null,
          "transcript": "ENST00000410012.7",
          "protein_id": null,
          "transcript_support_level": 2,
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      ],
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      "gnomad_mito_homoplasmic": null,
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      "computational_score_selected": 0.0938345193862915,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.07999999821186066,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
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      "revel_prediction": "Benign",
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      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.36,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 1.729,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0.08,
      "spliceai_max_prediction": "Benign",
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      "acmg_score": 0,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_by_gene": [
        {
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          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
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          "verdict": "Uncertain_significance",
          "transcript": "NM_001349008.3",
          "gene_symbol": "CC2D2B",
          "hgnc_id": 31666,
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            "missense_variant"
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        {
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          "pathogenic_score": 2,
          "criteria": [
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            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000416301.5",
          "gene_symbol": "ENTPD1-AS1",
          "hgnc_id": 45203,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.275+75432G>A",
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        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}
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