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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 10-96133669-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=96133669&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "10",
      "pos": 96133669,
      "ref": "G",
      "alt": "A",
      "effect": "intron_variant",
      "transcript": "ENST00000316045.10",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-302+21G>A",
          "hgvs_p": null,
          "transcript": "NM_001330736.2",
          "protein_id": "NP_001317665.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8345,
          "mane_select": "ENST00000316045.10",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-302+21G>A",
          "hgvs_p": null,
          "transcript": "ENST00000316045.10",
          "protein_id": "ENSP00000479684.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8345,
          "mane_select": "NM_001330736.2",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-324+21G>A",
          "hgvs_p": null,
          "transcript": "ENST00000624776.4",
          "protein_id": "ENSP00000485614.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8001,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LOC124902486",
          "gene_hgnc_id": null,
          "hgvs_c": "n.15061C>T",
          "hgvs_p": null,
          "transcript": "XR_007062254.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 19675,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-475+21G>A",
          "hgvs_p": null,
          "transcript": "NM_001278524.2",
          "protein_id": "NP_001265453.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8340,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-324+21G>A",
          "hgvs_p": null,
          "transcript": "NM_001278525.2",
          "protein_id": "NP_001265454.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8001,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-324+21G>A",
          "hgvs_p": null,
          "transcript": "NM_001330732.2",
          "protein_id": "NP_001317661.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 7974,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-453+21G>A",
          "hgvs_p": null,
          "transcript": "NM_001330733.1",
          "protein_id": "NP_001317662.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8542,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-453+21G>A",
          "hgvs_p": null,
          "transcript": "NM_001330734.1",
          "protein_id": "NP_001317663.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8243,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-302+21G>A",
          "hgvs_p": null,
          "transcript": "NM_001330735.1",
          "protein_id": "NP_001317664.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
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          "cdna_length": 8391,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-356+21G>A",
          "hgvs_p": null,
          "transcript": "NM_001330737.1",
          "protein_id": "NP_001317666.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": -4,
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          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8418,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-422+21G>A",
          "hgvs_p": null,
          "transcript": "NM_001330738.1",
          "protein_id": "NP_001317667.1",
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          "aa_length": 1483,
          "cds_start": -4,
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          "cdna_start": null,
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        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-402+21G>A",
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          "transcript": "NM_014803.4",
          "protein_id": "NP_055618.2",
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          "cds_start": -4,
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          "mane_select": null,
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        },
        {
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          "canonical": false,
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          "strand": true,
          "consequences": [
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          "intron_rank": 3,
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          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-402+21G>A",
          "hgvs_p": null,
          "transcript": "ENST00000614149.2",
          "protein_id": "ENSP00000481657.1",
          "transcript_support_level": 5,
          "aa_start": null,
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          "mane_select": null,
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        },
        {
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          ],
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          "exon_count": 7,
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          "gene_symbol": "ZNF518A",
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          "hgvs_c": "c.-350+21G>A",
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          "transcript": "NM_001278526.2",
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        {
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          "intron_rank": 3,
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          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "n.409+21G>A",
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          "transcript": "ENST00000488700.5",
          "protein_id": null,
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        },
        {
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          "exon_count": 5,
          "intron_rank": 3,
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          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "n.214+21G>A",
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          "transcript": "ENST00000539666.5",
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        },
        {
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 4,
          "intron_rank": 3,
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          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "n.225+21G>A",
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          "transcript": "ENST00000563195.1",
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          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "n.429+21G>A",
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        {
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          ],
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          "intron_rank": 3,
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          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-453+21G>A",
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          "transcript": "XM_011540406.3",
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          "feature": null
        },
        {
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          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-475+21G>A",
          "hgvs_p": null,
          "transcript": "XM_011540410.3",
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}