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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 10-96134774-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=96134774&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "10",
      "pos": 96134774,
      "ref": "G",
      "alt": "C",
      "effect": "intron_variant",
      "transcript": "NM_014803.4",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-302+1126G>C",
          "hgvs_p": null,
          "transcript": "NM_001330736.2",
          "protein_id": "NP_001317665.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000316045.10",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001330736.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-302+1126G>C",
          "hgvs_p": null,
          "transcript": "ENST00000316045.10",
          "protein_id": "ENSP00000479684.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_001330736.2",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000316045.10"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-324+1126G>C",
          "hgvs_p": null,
          "transcript": "ENST00000624776.4",
          "protein_id": "ENSP00000485614.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000624776.4"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-475+1126G>C",
          "hgvs_p": null,
          "transcript": "NM_001278524.2",
          "protein_id": "NP_001265453.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001278524.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-324+1126G>C",
          "hgvs_p": null,
          "transcript": "NM_001278525.2",
          "protein_id": "NP_001265454.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001278525.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-324+1126G>C",
          "hgvs_p": null,
          "transcript": "NM_001330732.2",
          "protein_id": "NP_001317661.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001330732.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-453+1126G>C",
          "hgvs_p": null,
          "transcript": "NM_001330733.1",
          "protein_id": "NP_001317662.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001330733.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-453+1126G>C",
          "hgvs_p": null,
          "transcript": "NM_001330734.1",
          "protein_id": "NP_001317663.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001330734.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-302+1126G>C",
          "hgvs_p": null,
          "transcript": "NM_001330735.1",
          "protein_id": "NP_001317664.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001330735.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-356+1126G>C",
          "hgvs_p": null,
          "transcript": "NM_001330737.1",
          "protein_id": "NP_001317666.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001330737.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-421-396G>C",
          "hgvs_p": null,
          "transcript": "NM_001330738.1",
          "protein_id": "NP_001317667.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1483,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001330738.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-402+1126G>C",
          "hgvs_p": null,
          "transcript": "NM_014803.4",
          "protein_id": "NP_055618.2",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 1483,
          "cds_start": null,
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          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_014803.4"
        },
        {
          "aa_ref": null,
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          "canonical": false,
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          "strand": true,
          "consequences": [
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          ],
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          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-402+1126G>C",
          "hgvs_p": null,
          "transcript": "ENST00000614149.2",
          "protein_id": "ENSP00000481657.1",
          "transcript_support_level": 5,
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          "biotype": "protein_coding",
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        },
        {
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          "canonical": false,
          "protein_coding": true,
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          ],
          "exon_rank": null,
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          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-421-396G>C",
          "hgvs_p": null,
          "transcript": "ENST00000863556.1",
          "protein_id": "ENSP00000533616.1",
          "transcript_support_level": null,
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          "cds_start": null,
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        },
        {
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        {
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          ],
          "exon_rank": null,
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          "exon_count": 7,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-302+1126G>C",
          "hgvs_p": null,
          "transcript": "ENST00000863559.1",
          "protein_id": "ENSP00000533618.1",
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        {
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          "exon_count": 7,
          "intron_rank": 3,
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          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-453+1126G>C",
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          "transcript": "ENST00000863560.1",
          "protein_id": "ENSP00000533619.1",
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        {
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        {
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        {
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          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ZNF518A",
          "gene_hgnc_id": 29009,
          "hgvs_c": "c.-453+1126G>C",
          "hgvs_p": null,
          "transcript": "ENST00000937971.1",
          "protein_id": "ENSP00000608030.1",
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          "cdna_start": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000937971.1"
        },
        {
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          "protein_coding": true,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.