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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 10-97753138-G-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=97753138&ref=G&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "10",
      "pos": 97753138,
      "ref": "G",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "ENST00000684270.1",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZFYVE27",
          "gene_hgnc_id": 26559,
          "hgvs_c": "c.998G>T",
          "hgvs_p": "p.Arg333Leu",
          "transcript": "NM_001385875.1",
          "protein_id": "NP_001372804.1",
          "transcript_support_level": null,
          "aa_start": 333,
          "aa_end": null,
          "aa_length": 411,
          "cds_start": 998,
          "cds_end": null,
          "cds_length": 1236,
          "cdna_start": 1193,
          "cdna_end": null,
          "cdna_length": 3026,
          "mane_select": "ENST00000684270.1",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZFYVE27",
          "gene_hgnc_id": 26559,
          "hgvs_c": "c.998G>T",
          "hgvs_p": "p.Arg333Leu",
          "transcript": "ENST00000684270.1",
          "protein_id": "ENSP00000506975.1",
          "transcript_support_level": null,
          "aa_start": 333,
          "aa_end": null,
          "aa_length": 411,
          "cds_start": 998,
          "cds_end": null,
          "cds_length": 1236,
          "cdna_start": 1193,
          "cdna_end": null,
          "cdna_length": 3026,
          "mane_select": "NM_001385875.1",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZFYVE27",
          "gene_hgnc_id": 26559,
          "hgvs_c": "c.998G>T",
          "hgvs_p": "p.Arg333Leu",
          "transcript": "ENST00000393677.8",
          "protein_id": "ENSP00000377282.3",
          "transcript_support_level": 1,
          "aa_start": 333,
          "aa_end": null,
          "aa_length": 411,
          "cds_start": 998,
          "cds_end": null,
          "cds_length": 1236,
          "cdna_start": 1202,
          "cdna_end": null,
          "cdna_length": 3047,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZFYVE27",
          "gene_hgnc_id": 26559,
          "hgvs_c": "c.1031G>T",
          "hgvs_p": "p.Arg344Leu",
          "transcript": "NM_001385876.1",
          "protein_id": "NP_001372805.1",
          "transcript_support_level": null,
          "aa_start": 344,
          "aa_end": null,
          "aa_length": 422,
          "cds_start": 1031,
          "cds_end": null,
          "cds_length": 1269,
          "cdna_start": 1230,
          "cdna_end": null,
          "cdna_length": 3063,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZFYVE27",
          "gene_hgnc_id": 26559,
          "hgvs_c": "c.1013G>T",
          "hgvs_p": "p.Arg338Leu",
          "transcript": "NM_001002261.4",
          "protein_id": "NP_001002261.1",
          "transcript_support_level": null,
          "aa_start": 338,
          "aa_end": null,
          "aa_length": 416,
          "cds_start": 1013,
          "cds_end": null,
          "cds_length": 1251,
          "cdna_start": 1208,
          "cdna_end": null,
          "cdna_length": 3041,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZFYVE27",
          "gene_hgnc_id": 26559,
          "hgvs_c": "c.1013G>T",
          "hgvs_p": "p.Arg338Leu",
          "transcript": "NM_001385871.1",
          "protein_id": "NP_001372800.1",
          "transcript_support_level": null,
          "aa_start": 338,
          "aa_end": null,
          "aa_length": 416,
          "cds_start": 1013,
          "cds_end": null,
          "cds_length": 1251,
          "cdna_start": 1212,
          "cdna_end": null,
          "cdna_length": 3045,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZFYVE27",
          "gene_hgnc_id": 26559,
          "hgvs_c": "c.1013G>T",
          "hgvs_p": "p.Arg338Leu",
          "transcript": "ENST00000423811.3",
          "protein_id": "ENSP00000409594.2",
          "transcript_support_level": 5,
          "aa_start": 338,
          "aa_end": null,
          "aa_length": 416,
          "cds_start": 1013,
          "cds_end": null,
          "cds_length": 1251,
          "cdna_start": 1212,
          "cdna_end": null,
          "cdna_length": 3045,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZFYVE27",
          "gene_hgnc_id": 26559,
          "hgvs_c": "c.998G>T",
          "hgvs_p": "p.Arg333Leu",
          "transcript": "NM_144588.7",
          "protein_id": "NP_653189.3",
          "transcript_support_level": null,
          "aa_start": 333,
          "aa_end": null,
          "aa_length": 411,
          "cds_start": 998,
          "cds_end": null,
          "cds_length": 1236,
          "cdna_start": 1197,
          "cdna_end": null,
          "cdna_length": 3030,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZFYVE27",
          "gene_hgnc_id": 26559,
          "hgvs_c": "c.995G>T",
          "hgvs_p": "p.Arg332Leu",
          "transcript": "NM_001385877.1",
          "protein_id": "NP_001372806.1",
          "transcript_support_level": null,
          "aa_start": 332,
          "aa_end": null,
          "aa_length": 410,
          "cds_start": 995,
          "cds_end": null,
          "cds_length": 1233,
          "cdna_start": 1190,
          "cdna_end": null,
          "cdna_length": 3023,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZFYVE27",
          "gene_hgnc_id": 26559,
          "hgvs_c": "c.992G>T",
          "hgvs_p": "p.Arg331Leu",
          "transcript": "NM_001385878.1",
          "protein_id": "NP_001372807.1",
          "transcript_support_level": null,
          "aa_start": 331,
          "aa_end": null,
          "aa_length": 409,
          "cds_start": 992,
          "cds_end": null,
          "cds_length": 1230,
          "cdna_start": 1187,
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          "mane_select": null,
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        {
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          ],
          "exon_rank": 9,
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          "gene_symbol": "ZFYVE27",
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          "hgvs_c": "c.992G>T",
          "hgvs_p": "p.Arg331Leu",
          "transcript": "NM_001385879.1",
          "protein_id": "NP_001372808.1",
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          "aa_start": 331,
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          "cds_start": 992,
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          "cdna_start": 1191,
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          "cdna_length": 3024,
          "mane_select": null,
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        },
        {
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          "canonical": false,
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          "strand": true,
          "consequences": [
            "missense_variant"
          ],
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          "intron_rank": null,
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          "gene_symbol": "ZFYVE27",
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          "hgvs_c": "c.977G>T",
          "hgvs_p": "p.Arg326Leu",
          "transcript": "NM_001002262.4",
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        {
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          "gene_hgnc_id": 26559,
          "hgvs_c": "c.977G>T",
          "hgvs_p": "p.Arg326Leu",
          "transcript": "NM_001385880.1",
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        {
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          "strand": true,
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          ],
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          "intron_rank": null,
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          "gene_symbol": "ZFYVE27",
          "gene_hgnc_id": 26559,
          "hgvs_c": "c.977G>T",
          "hgvs_p": "p.Arg326Leu",
          "transcript": "NM_001385881.1",
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        {
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        {
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          "gene_symbol": "ZFYVE27",
          "gene_hgnc_id": 26559,
          "hgvs_c": "c.992G>T",
          "hgvs_p": "p.Arg331Leu",
          "transcript": "NM_001385882.1",
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        {
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          "transcript": "NM_001385883.1",
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        {
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        {
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        {
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          "intron_rank": null,
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          "gene_symbol": "ZFYVE27",
          "gene_hgnc_id": 26559,
          "hgvs_c": "c.896G>T",
          "hgvs_p": "p.Arg299Leu",
          "transcript": "NM_001385886.1",
          "protein_id": "NP_001372815.1",
          "transcript_support_level": null,
          "aa_start": 299,
          "aa_end": null,
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          "cdna_start": 1091,
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          "biotype": null,
          "feature": null
        },
        {
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          "consequences": [
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          ],
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          "exon_count": 11,
          "intron_rank": null,
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}