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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 10-98202516-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=98202516&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "10",
      "pos": 98202516,
      "ref": "G",
      "alt": "A",
      "effect": "intron_variant",
      "transcript": "ENST00000298999.8",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "NM_001351015.2",
          "protein_id": "NP_001337944.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 778,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2337,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3393,
          "mane_select": "ENST00000298999.8",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "ENST00000298999.8",
          "protein_id": "ENSP00000298999.3",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 778,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2337,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3393,
          "mane_select": "NM_001351015.2",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "NM_001256619.2",
          "protein_id": "NP_001243548.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 792,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2379,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3435,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "ENST00000612478.4",
          "protein_id": "ENSP00000483494.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 792,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2379,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3337,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "NM_001256620.2",
          "protein_id": "NP_001243549.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 778,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2337,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3342,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "NM_001351010.2",
          "protein_id": "NP_001337939.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 778,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2337,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3568,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "NM_001351011.2",
          "protein_id": "NP_001337940.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 778,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2337,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3504,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "NM_001351012.2",
          "protein_id": "NP_001337941.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 778,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2337,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3656,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "NM_001351013.2",
          "protein_id": "NP_001337942.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 778,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2337,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3245,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "NM_001351014.2",
          "protein_id": "NP_001337943.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 778,
          "cds_start": -4,
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          "cds_length": 2337,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3490,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 7,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "NM_001351016.2",
          "protein_id": "NP_001337945.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
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          "cds_start": -4,
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          "cds_length": 2337,
          "cdna_start": null,
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          "cdna_length": 3140,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
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          "transcript": "NM_001351017.2",
          "protein_id": "NP_001337946.2",
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          "mane_select": null,
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        {
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          "consequences": [
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          ],
          "exon_rank": null,
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          "intron_rank": 3,
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          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "NM_014472.5",
          "protein_id": "NP_055287.5",
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        {
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          "exon_count": 10,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "NM_138469.3",
          "protein_id": "NP_612478.3",
          "transcript_support_level": null,
          "aa_start": null,
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          "mane_select": null,
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        },
        {
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          ],
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          "hgvs_c": "c.-14-5585G>A",
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          "transcript": "ENST00000314594.6",
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          ],
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          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "ENST00000370584.7",
          "protein_id": "ENSP00000359616.3",
          "transcript_support_level": 2,
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        {
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          "exon_count": 8,
          "intron_rank": 3,
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          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.4-28996G>A",
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          "transcript": "NM_001256621.2",
          "protein_id": "NP_001243550.2",
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        },
        {
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          ],
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          "gene_symbol": "R3HCC1L",
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          "intron_rank": 1,
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          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.4-28996G>A",
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        {
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          ],
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          "exon_count": 12,
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          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "XM_011539640.2",
          "protein_id": "XP_011537942.1",
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          "cds_start": -4,
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          "cdna_start": null,
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          "cdna_length": 3532,
          "mane_select": null,
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        },
        {
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          "protein_coding": true,
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          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 11,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "R3HCC1L",
          "gene_hgnc_id": 23512,
          "hgvs_c": "c.-14-5585G>A",
          "hgvs_p": null,
          "transcript": "XM_011539641.2",
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}