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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-98385006-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=98385006&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 98385006,
"ref": "T",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_032709.3",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1616A>C",
"hgvs_p": "p.His539Pro",
"transcript": "NM_032709.3",
"protein_id": "NP_116098.2",
"transcript_support_level": null,
"aa_start": 539,
"aa_end": null,
"aa_length": 581,
"cds_start": 1616,
"cds_end": null,
"cds_length": 1746,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000370575.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032709.3"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1616A>C",
"hgvs_p": "p.His539Pro",
"transcript": "ENST00000370575.5",
"protein_id": "ENSP00000359607.4",
"transcript_support_level": 1,
"aa_start": 539,
"aa_end": null,
"aa_length": 581,
"cds_start": 1616,
"cds_end": null,
"cds_length": 1746,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_032709.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000370575.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "n.2502A>C",
"hgvs_p": null,
"transcript": "ENST00000483923.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000483923.5"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1760A>C",
"hgvs_p": "p.His587Pro",
"transcript": "ENST00000906254.1",
"protein_id": "ENSP00000576313.1",
"transcript_support_level": null,
"aa_start": 587,
"aa_end": null,
"aa_length": 629,
"cds_start": 1760,
"cds_end": null,
"cds_length": 1890,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906254.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1757A>C",
"hgvs_p": "p.His586Pro",
"transcript": "ENST00000965723.1",
"protein_id": "ENSP00000635782.1",
"transcript_support_level": null,
"aa_start": 586,
"aa_end": null,
"aa_length": 628,
"cds_start": 1757,
"cds_end": null,
"cds_length": 1887,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965723.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1739A>C",
"hgvs_p": "p.His580Pro",
"transcript": "ENST00000965722.1",
"protein_id": "ENSP00000635781.1",
"transcript_support_level": null,
"aa_start": 580,
"aa_end": null,
"aa_length": 622,
"cds_start": 1739,
"cds_end": null,
"cds_length": 1869,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965722.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1730A>C",
"hgvs_p": "p.His577Pro",
"transcript": "ENST00000906252.1",
"protein_id": "ENSP00000576311.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 619,
"cds_start": 1730,
"cds_end": null,
"cds_length": 1860,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906252.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1481A>C",
"hgvs_p": "p.His494Pro",
"transcript": "ENST00000906253.1",
"protein_id": "ENSP00000576312.1",
"transcript_support_level": null,
"aa_start": 494,
"aa_end": null,
"aa_length": 536,
"cds_start": 1481,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906253.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1832A>C",
"hgvs_p": "p.His611Pro",
"transcript": "XM_047425881.1",
"protein_id": "XP_047281837.1",
"transcript_support_level": null,
"aa_start": 611,
"aa_end": null,
"aa_length": 653,
"cds_start": 1832,
"cds_end": null,
"cds_length": 1962,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047425881.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1730A>C",
"hgvs_p": "p.His577Pro",
"transcript": "XM_047425882.1",
"protein_id": "XP_047281838.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 619,
"cds_start": 1730,
"cds_end": null,
"cds_length": 1860,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047425882.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1718A>C",
"hgvs_p": "p.His573Pro",
"transcript": "XM_011540293.3",
"protein_id": "XP_011538595.1",
"transcript_support_level": null,
"aa_start": 573,
"aa_end": null,
"aa_length": 615,
"cds_start": 1718,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011540293.3"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1730A>C",
"hgvs_p": "p.His577Pro",
"transcript": "XM_047425883.1",
"protein_id": "XP_047281839.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 598,
"cds_start": 1730,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047425883.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1718A>C",
"hgvs_p": "p.His573Pro",
"transcript": "XM_047425884.1",
"protein_id": "XP_047281840.1",
"transcript_support_level": null,
"aa_start": 573,
"aa_end": null,
"aa_length": 594,
"cds_start": 1718,
"cds_end": null,
"cds_length": 1785,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047425884.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1616A>C",
"hgvs_p": "p.His539Pro",
"transcript": "XM_017016835.2",
"protein_id": "XP_016872324.1",
"transcript_support_level": null,
"aa_start": 539,
"aa_end": null,
"aa_length": 560,
"cds_start": 1616,
"cds_end": null,
"cds_length": 1683,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017016835.2"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1367A>C",
"hgvs_p": "p.His456Pro",
"transcript": "XM_047425887.1",
"protein_id": "XP_047281843.1",
"transcript_support_level": null,
"aa_start": 456,
"aa_end": null,
"aa_length": 498,
"cds_start": 1367,
"cds_end": null,
"cds_length": 1497,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047425887.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1367A>C",
"hgvs_p": "p.His456Pro",
"transcript": "XM_047425888.1",
"protein_id": "XP_047281844.1",
"transcript_support_level": null,
"aa_start": 456,
"aa_end": null,
"aa_length": 498,
"cds_start": 1367,
"cds_end": null,
"cds_length": 1497,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047425888.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1253A>C",
"hgvs_p": "p.His418Pro",
"transcript": "XM_017016839.3",
"protein_id": "XP_016872328.1",
"transcript_support_level": null,
"aa_start": 418,
"aa_end": null,
"aa_length": 460,
"cds_start": 1253,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017016839.3"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1253A>C",
"hgvs_p": "p.His418Pro",
"transcript": "XM_017016840.2",
"protein_id": "XP_016872329.1",
"transcript_support_level": null,
"aa_start": 418,
"aa_end": null,
"aa_length": 460,
"cds_start": 1253,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017016840.2"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.1253A>C",
"hgvs_p": "p.His418Pro",
"transcript": "XM_017016841.2",
"protein_id": "XP_016872330.1",
"transcript_support_level": null,
"aa_start": 418,
"aa_end": null,
"aa_length": 460,
"cds_start": 1253,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017016841.2"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.860A>C",
"hgvs_p": "p.His287Pro",
"transcript": "XM_047425891.1",
"protein_id": "XP_047281847.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 329,
"cds_start": 860,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047425891.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.809A>C",
"hgvs_p": "p.His270Pro",
"transcript": "XM_011540301.3",
"protein_id": "XP_011538603.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 312,
"cds_start": 809,
"cds_end": null,
"cds_length": 939,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011540301.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PYROXD2",
"gene_hgnc_id": 23517,
"hgvs_c": "c.*146A>C",
"hgvs_p": null,
"transcript": "XM_047425885.1",
"protein_id": "XP_047281841.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 566,
"cds_start": null,
"cds_end": null,
"cds_length": 1701,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
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{
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],
"gene_symbol": "PYROXD2",
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"hom_count_reference_population": 0,
"allele_count_reference_population": 1,
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"gnomad_exomes_ac": 1,
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"gnomad_exomes_homalt": 0,
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"gnomad_mito_homoplasmic": null,
"gnomad_mito_heteroplasmic": null,
"computational_score_selected": 0.23663872480392456,
"computational_prediction_selected": "Benign",
"computational_source_selected": "MetaRNN",
"splice_score_selected": 0,
"splice_prediction_selected": "Benign",
"splice_source_selected": "max_spliceai",
"revel_score": 0.104,
"revel_prediction": "Benign",
"alphamissense_score": 0.1619,
"alphamissense_prediction": "Benign",
"bayesdelnoaf_score": -0.39,
"bayesdelnoaf_prediction": "Benign",
"phylop100way_score": 5.699,
"phylop100way_prediction": "Uncertain_significance",
"spliceai_max_score": 0,
"spliceai_max_prediction": "Benign",
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"dbscsnv_ada_prediction": null,
"apogee2_score": null,
"apogee2_prediction": null,
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"acmg_score": 0,
"acmg_classification": "Uncertain_significance",
"acmg_criteria": "PM2,BP4_Moderate",
"acmg_by_gene": [
{
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"pathogenic_score": 2,
"criteria": [
"PM2",
"BP4_Moderate"
],
"verdict": "Uncertain_significance",
"transcript": "NM_032709.3",
"gene_symbol": "PYROXD2",
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"effects": [
"missense_variant"
],
"inheritance_mode": "AR",
"hgvs_c": "c.1616A>C",
"hgvs_p": "p.His539Pro"
}
],
"clinvar_disease": "",
"clinvar_classification": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"phenotype_combined": null,
"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}