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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-112061088-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=112061088&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 112061088,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000280346.11",
"consequences": [
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1728C>A",
"hgvs_p": "p.Phe576Leu",
"transcript": "NM_001931.5",
"protein_id": "NP_001922.2",
"transcript_support_level": null,
"aa_start": 576,
"aa_end": null,
"aa_length": 647,
"cds_start": 1728,
"cds_end": null,
"cds_length": 1944,
"cdna_start": 1793,
"cdna_end": null,
"cdna_length": 3878,
"mane_select": "ENST00000280346.11",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1728C>A",
"hgvs_p": "p.Phe576Leu",
"transcript": "ENST00000280346.11",
"protein_id": "ENSP00000280346.7",
"transcript_support_level": 1,
"aa_start": 576,
"aa_end": null,
"aa_length": 647,
"cds_start": 1728,
"cds_end": null,
"cds_length": 1944,
"cdna_start": 1793,
"cdna_end": null,
"cdna_length": 3878,
"mane_select": "NM_001931.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1746C>A",
"hgvs_p": "p.Phe582Leu",
"transcript": "NM_001372031.1",
"protein_id": "NP_001358960.1",
"transcript_support_level": null,
"aa_start": 582,
"aa_end": null,
"aa_length": 653,
"cds_start": 1746,
"cds_end": null,
"cds_length": 1962,
"cdna_start": 1811,
"cdna_end": null,
"cdna_length": 3896,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1728C>A",
"hgvs_p": "p.Phe576Leu",
"transcript": "ENST00000713569.1",
"protein_id": "ENSP00000518862.1",
"transcript_support_level": null,
"aa_start": 576,
"aa_end": null,
"aa_length": 647,
"cds_start": 1728,
"cds_end": null,
"cds_length": 1944,
"cdna_start": 2168,
"cdna_end": null,
"cdna_length": 3465,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1722C>A",
"hgvs_p": "p.Phe574Leu",
"transcript": "NM_001372032.1",
"protein_id": "NP_001358961.1",
"transcript_support_level": null,
"aa_start": 574,
"aa_end": null,
"aa_length": 645,
"cds_start": 1722,
"cds_end": null,
"cds_length": 1938,
"cdna_start": 1787,
"cdna_end": null,
"cdna_length": 3872,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1722C>A",
"hgvs_p": "p.Phe574Leu",
"transcript": "ENST00000681316.1",
"protein_id": "ENSP00000506560.1",
"transcript_support_level": null,
"aa_start": 574,
"aa_end": null,
"aa_length": 645,
"cds_start": 1722,
"cds_end": null,
"cds_length": 1938,
"cdna_start": 1769,
"cdna_end": null,
"cdna_length": 3825,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1707C>A",
"hgvs_p": "p.Phe569Leu",
"transcript": "NM_001372033.1",
"protein_id": "NP_001358962.1",
"transcript_support_level": null,
"aa_start": 569,
"aa_end": null,
"aa_length": 640,
"cds_start": 1707,
"cds_end": null,
"cds_length": 1923,
"cdna_start": 1772,
"cdna_end": null,
"cdna_length": 3857,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1707C>A",
"hgvs_p": "p.Phe569Leu",
"transcript": "ENST00000681328.1",
"protein_id": "ENSP00000506355.1",
"transcript_support_level": null,
"aa_start": 569,
"aa_end": null,
"aa_length": 640,
"cds_start": 1707,
"cds_end": null,
"cds_length": 1923,
"cdna_start": 1754,
"cdna_end": null,
"cdna_length": 3810,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1695C>A",
"hgvs_p": "p.Phe565Leu",
"transcript": "NM_001372034.1",
"protein_id": "NP_001358963.1",
"transcript_support_level": null,
"aa_start": 565,
"aa_end": null,
"aa_length": 636,
"cds_start": 1695,
"cds_end": null,
"cds_length": 1911,
"cdna_start": 1760,
"cdna_end": null,
"cdna_length": 3845,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1695C>A",
"hgvs_p": "p.Phe565Leu",
"transcript": "ENST00000679878.1",
"protein_id": "ENSP00000505567.1",
"transcript_support_level": null,
"aa_start": 565,
"aa_end": null,
"aa_length": 636,
"cds_start": 1695,
"cds_end": null,
"cds_length": 1911,
"cdna_start": 1760,
"cdna_end": null,
"cdna_length": 3830,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1620C>A",
"hgvs_p": "p.Phe540Leu",
"transcript": "NM_001372035.1",
"protein_id": "NP_001358964.1",
"transcript_support_level": null,
"aa_start": 540,
"aa_end": null,
"aa_length": 611,
"cds_start": 1620,
"cds_end": null,
"cds_length": 1836,
"cdna_start": 1685,
"cdna_end": null,
"cdna_length": 3770,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1620C>A",
"hgvs_p": "p.Phe540Leu",
"transcript": "ENST00000681339.1",
"protein_id": "ENSP00000506167.1",
"transcript_support_level": null,
"aa_start": 540,
"aa_end": null,
"aa_length": 611,
"cds_start": 1620,
"cds_end": null,
"cds_length": 1836,
"cdna_start": 1667,
"cdna_end": null,
"cdna_length": 3723,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1602C>A",
"hgvs_p": "p.Phe534Leu",
"transcript": "NM_001372036.1",
"protein_id": "NP_001358965.1",
"transcript_support_level": null,
"aa_start": 534,
"aa_end": null,
"aa_length": 605,
"cds_start": 1602,
"cds_end": null,
"cds_length": 1818,
"cdna_start": 1708,
"cdna_end": null,
"cdna_length": 3793,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1560C>A",
"hgvs_p": "p.Phe520Leu",
"transcript": "NM_001372037.1",
"protein_id": "NP_001358966.1",
"transcript_support_level": null,
"aa_start": 520,
"aa_end": null,
"aa_length": 591,
"cds_start": 1560,
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"cdna_start": 1666,
"cdna_end": null,
"cdna_length": 3751,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1473C>A",
"hgvs_p": "p.Phe491Leu",
"transcript": "ENST00000680411.1",
"protein_id": "ENSP00000505915.1",
"transcript_support_level": null,
"aa_start": 491,
"aa_end": null,
"aa_length": 562,
"cds_start": 1473,
"cds_end": null,
"cds_length": 1689,
"cdna_start": 1670,
"cdna_end": null,
"cdna_length": 3740,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1449C>A",
"hgvs_p": "p.Phe483Leu",
"transcript": "NM_001372038.1",
"protein_id": "NP_001358967.1",
"transcript_support_level": null,
"aa_start": 483,
"aa_end": null,
"aa_length": 554,
"cds_start": 1449,
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"cdna_start": 1514,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1449C>A",
"hgvs_p": "p.Phe483Leu",
"transcript": "ENST00000680331.1",
"protein_id": "ENSP00000506707.1",
"transcript_support_level": null,
"aa_start": 483,
"aa_end": null,
"aa_length": 554,
"cds_start": 1449,
"cds_end": null,
"cds_length": 1665,
"cdna_start": 1482,
"cdna_end": null,
"cdna_length": 3552,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1413C>A",
"hgvs_p": "p.Phe471Leu",
"transcript": "NM_001372039.1",
"protein_id": "NP_001358968.1",
"transcript_support_level": null,
"aa_start": 471,
"aa_end": null,
"aa_length": 542,
"cds_start": 1413,
"cds_end": null,
"cds_length": 1629,
"cdna_start": 1478,
"cdna_end": null,
"cdna_length": 3563,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1413C>A",
"hgvs_p": "p.Phe471Leu",
"transcript": "ENST00000393051.5",
"protein_id": "ENSP00000376771.1",
"transcript_support_level": 5,
"aa_start": 471,
"aa_end": null,
"aa_length": 542,
"cds_start": 1413,
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"cdna_start": 1446,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1347C>A",
"hgvs_p": "p.Phe449Leu",
"transcript": "NM_001372040.1",
"protein_id": "NP_001358969.1",
"transcript_support_level": null,
"aa_start": 449,
"aa_end": null,
"aa_length": 520,
"cds_start": 1347,
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"cdna_start": 1412,
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"cdna_length": 3497,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1347C>A",
"hgvs_p": "p.Phe449Leu",
"transcript": "ENST00000531306.2",
"protein_id": "ENSP00000433432.2",
"transcript_support_level": 2,
"aa_start": 449,
"aa_end": null,
"aa_length": 520,
"cds_start": 1347,
"cds_end": null,
"cds_length": 1563,
"cdna_start": 1389,
"cdna_end": null,
"cdna_length": 1931,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
"gene_hgnc_id": 2896,
"hgvs_c": "c.1305C>A",
"hgvs_p": "p.Phe435Leu",
"transcript": "NM_001372041.1",
"protein_id": "NP_001358970.1",
"transcript_support_level": null,
"aa_start": 435,
"aa_end": null,
"aa_length": 506,
"cds_start": 1305,
"cds_end": null,
"cds_length": 1521,
"cdna_start": 1370,
"cdna_end": null,
"cdna_length": 3455,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DLAT",
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}