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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-113834299-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=113834299&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 113834299,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000696973.1",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.571C>T",
"hgvs_p": "p.Leu191Phe",
"transcript": "NM_001346252.4",
"protein_id": "NP_001333181.1",
"transcript_support_level": null,
"aa_start": 191,
"aa_end": null,
"aa_length": 1139,
"cds_start": 571,
"cds_end": null,
"cds_length": 3420,
"cdna_start": 642,
"cdna_end": null,
"cdna_length": 4856,
"mane_select": "ENST00000696973.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.571C>T",
"hgvs_p": "p.Leu191Phe",
"transcript": "ENST00000696973.1",
"protein_id": "ENSP00000513009.1",
"transcript_support_level": null,
"aa_start": 191,
"aa_end": null,
"aa_length": 1139,
"cds_start": 571,
"cds_end": null,
"cds_length": 3420,
"cdna_start": 642,
"cdna_end": null,
"cdna_length": 4856,
"mane_select": "NM_001346252.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.571C>T",
"hgvs_p": "p.Leu191Phe",
"transcript": "ENST00000003302.8",
"protein_id": "ENSP00000003302.4",
"transcript_support_level": 1,
"aa_start": 191,
"aa_end": null,
"aa_length": 1077,
"cds_start": 571,
"cds_end": null,
"cds_length": 3234,
"cdna_start": 640,
"cdna_end": null,
"cdna_length": 4669,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.571C>T",
"hgvs_p": "p.Leu191Phe",
"transcript": "ENST00000537706.5",
"protein_id": "ENSP00000445743.1",
"transcript_support_level": 1,
"aa_start": 191,
"aa_end": null,
"aa_length": 583,
"cds_start": 571,
"cds_end": null,
"cds_length": 1752,
"cdna_start": 598,
"cdna_end": null,
"cdna_length": 1900,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.571C>T",
"hgvs_p": "p.Leu191Phe",
"transcript": "NM_001400785.1",
"protein_id": "NP_001387714.1",
"transcript_support_level": null,
"aa_start": 191,
"aa_end": null,
"aa_length": 1140,
"cds_start": 571,
"cds_end": null,
"cds_length": 3423,
"cdna_start": 642,
"cdna_end": null,
"cdna_length": 4859,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.493C>T",
"hgvs_p": "p.Leu165Phe",
"transcript": "NM_001400784.1",
"protein_id": "NP_001387713.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 1114,
"cds_start": 493,
"cds_end": null,
"cds_length": 3345,
"cdna_start": 564,
"cdna_end": null,
"cdna_length": 4781,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.493C>T",
"hgvs_p": "p.Leu165Phe",
"transcript": "NM_001346253.2",
"protein_id": "NP_001333182.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 1113,
"cds_start": 493,
"cds_end": null,
"cds_length": 3342,
"cdna_start": 564,
"cdna_end": null,
"cdna_length": 4778,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.571C>T",
"hgvs_p": "p.Leu191Phe",
"transcript": "NM_001400786.1",
"protein_id": "NP_001387715.1",
"transcript_support_level": null,
"aa_start": 191,
"aa_end": null,
"aa_length": 1107,
"cds_start": 571,
"cds_end": null,
"cds_length": 3324,
"cdna_start": 642,
"cdna_end": null,
"cdna_length": 4760,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.571C>T",
"hgvs_p": "p.Leu191Phe",
"transcript": "NM_001346254.2",
"protein_id": "NP_001333183.1",
"transcript_support_level": null,
"aa_start": 191,
"aa_end": null,
"aa_length": 1078,
"cds_start": 571,
"cds_end": null,
"cds_length": 3237,
"cdna_start": 642,
"cdna_end": null,
"cdna_length": 4673,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.571C>T",
"hgvs_p": "p.Leu191Phe",
"transcript": "NM_020886.4",
"protein_id": "NP_065937.1",
"transcript_support_level": null,
"aa_start": 191,
"aa_end": null,
"aa_length": 1077,
"cds_start": 571,
"cds_end": null,
"cds_length": 3234,
"cdna_start": 642,
"cdna_end": null,
"cdna_length": 4670,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.562C>T",
"hgvs_p": "p.Leu188Phe",
"transcript": "NM_001346255.2",
"protein_id": "NP_001333184.1",
"transcript_support_level": null,
"aa_start": 188,
"aa_end": null,
"aa_length": 1074,
"cds_start": 562,
"cds_end": null,
"cds_length": 3225,
"cdna_start": 1005,
"cdna_end": null,
"cdna_length": 5033,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.493C>T",
"hgvs_p": "p.Leu165Phe",
"transcript": "NM_001346257.2",
"protein_id": "NP_001333186.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 1051,
"cds_start": 493,
"cds_end": null,
"cds_length": 3156,
"cdna_start": 564,
"cdna_end": null,
"cdna_length": 4592,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.571C>T",
"hgvs_p": "p.Leu191Phe",
"transcript": "NM_001400787.1",
"protein_id": "NP_001387716.1",
"transcript_support_level": null,
"aa_start": 191,
"aa_end": null,
"aa_length": 1046,
"cds_start": 571,
"cds_end": null,
"cds_length": 3141,
"cdna_start": 642,
"cdna_end": null,
"cdna_length": 4577,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.571C>T",
"hgvs_p": "p.Leu191Phe",
"transcript": "NM_001346258.2",
"protein_id": "NP_001333187.1",
"transcript_support_level": null,
"aa_start": 191,
"aa_end": null,
"aa_length": 1045,
"cds_start": 571,
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"cdna_start": 642,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.562C>T",
"hgvs_p": "p.Leu188Phe",
"transcript": "NM_001400797.1",
"protein_id": "NP_001387726.1",
"transcript_support_level": null,
"aa_start": 188,
"aa_end": null,
"aa_length": 1043,
"cds_start": 562,
"cds_end": null,
"cds_length": 3132,
"cdna_start": 1005,
"cdna_end": null,
"cdna_length": 4940,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.562C>T",
"hgvs_p": "p.Leu188Phe",
"transcript": "NM_001400795.1",
"protein_id": "NP_001387724.1",
"transcript_support_level": null,
"aa_start": 188,
"aa_end": null,
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"cds_start": 562,
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"cdna_start": 926,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.562C>T",
"hgvs_p": "p.Leu188Phe",
"transcript": "NM_001400796.1",
"protein_id": "NP_001387725.1",
"transcript_support_level": null,
"aa_start": 188,
"aa_end": null,
"aa_length": 1042,
"cds_start": 562,
"cds_end": null,
"cds_length": 3129,
"cdna_start": 1005,
"cdna_end": null,
"cdna_length": 4937,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.493C>T",
"hgvs_p": "p.Leu165Phe",
"transcript": "NM_001400789.1",
"protein_id": "NP_001387718.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 1020,
"cds_start": 493,
"cds_end": null,
"cds_length": 3063,
"cdna_start": 564,
"cdna_end": null,
"cdna_length": 4499,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.493C>T",
"hgvs_p": "p.Leu165Phe",
"transcript": "NM_001346259.2",
"protein_id": "NP_001333188.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
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"cds_start": 493,
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"cdna_start": 564,
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"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.571C>T",
"hgvs_p": "p.Leu191Phe",
"transcript": "NM_001400792.1",
"protein_id": "NP_001387721.1",
"transcript_support_level": null,
"aa_start": 191,
"aa_end": null,
"aa_length": 985,
"cds_start": 571,
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"cdna_start": 642,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.493C>T",
"hgvs_p": "p.Leu165Phe",
"transcript": "NM_001400793.1",
"protein_id": "NP_001387722.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 959,
"cds_start": 493,
"cds_end": null,
"cds_length": 2880,
"cdna_start": 564,
"cdna_end": null,
"cdna_length": 4316,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.196C>T",
"hgvs_p": "p.Leu66Phe",
"transcript": "NM_001346260.2",
"protein_id": "NP_001333189.1",
"transcript_support_level": null,
"aa_start": 66,
"aa_end": null,
"aa_length": 953,
"cds_start": 196,
"cds_end": null,
"cds_length": 2862,
"cdna_start": 431,
"cdna_end": null,
"cdna_length": 4462,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP28",
"gene_hgnc_id": 12625,
"hgvs_c": "c.196C>T",
"hgvs_p": "p.Leu66Phe",
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"clinvar_review_status": "no assertion criteria provided",
"clinvar_submissions_summary": "null",
"phenotype_combined": "Prostate cancer",
"pathogenicity_classification_combined": "Uncertain significance",
"custom_annotations": null
}
],
"message": null
}