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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-115178666-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=115178666&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 115178666,
"ref": "C",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_001301043.2",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1275G>T",
"hgvs_p": "p.Gly425Gly",
"transcript": "NM_001301043.2",
"protein_id": "NP_001287972.1",
"transcript_support_level": null,
"aa_start": 425,
"aa_end": null,
"aa_length": 471,
"cds_start": 1275,
"cds_end": null,
"cds_length": 1416,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000331581.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001301043.2"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1275G>T",
"hgvs_p": "p.Gly425Gly",
"transcript": "ENST00000331581.11",
"protein_id": "ENSP00000329797.6",
"transcript_support_level": 1,
"aa_start": 425,
"aa_end": null,
"aa_length": 471,
"cds_start": 1275,
"cds_end": null,
"cds_length": 1416,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001301043.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000331581.11"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1221G>T",
"hgvs_p": "p.Gly407Gly",
"transcript": "ENST00000537058.5",
"protein_id": "ENSP00000439817.1",
"transcript_support_level": 1,
"aa_start": 407,
"aa_end": null,
"aa_length": 453,
"cds_start": 1221,
"cds_end": null,
"cds_length": 1362,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000537058.5"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1191G>T",
"hgvs_p": "p.Gly397Gly",
"transcript": "ENST00000536727.5",
"protein_id": "ENSP00000440322.1",
"transcript_support_level": 1,
"aa_start": 397,
"aa_end": null,
"aa_length": 443,
"cds_start": 1191,
"cds_end": null,
"cds_length": 1332,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000536727.5"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1188G>T",
"hgvs_p": "p.Gly396Gly",
"transcript": "ENST00000452722.7",
"protein_id": "ENSP00000395359.2",
"transcript_support_level": 1,
"aa_start": 396,
"aa_end": null,
"aa_length": 442,
"cds_start": 1188,
"cds_end": null,
"cds_length": 1329,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000452722.7"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1104G>T",
"hgvs_p": "p.Gly368Gly",
"transcript": "ENST00000542447.6",
"protein_id": "ENSP00000439176.1",
"transcript_support_level": 1,
"aa_start": 368,
"aa_end": null,
"aa_length": 414,
"cds_start": 1104,
"cds_end": null,
"cds_length": 1245,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000542447.6"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1098G>T",
"hgvs_p": "p.Gly366Gly",
"transcript": "ENST00000545380.5",
"protein_id": "ENSP00000442387.1",
"transcript_support_level": 1,
"aa_start": 366,
"aa_end": null,
"aa_length": 412,
"cds_start": 1098,
"cds_end": null,
"cds_length": 1239,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000545380.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "n.1233G>T",
"hgvs_p": null,
"transcript": "ENST00000537140.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000537140.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "n.446G>T",
"hgvs_p": null,
"transcript": "ENST00000546000.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000546000.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1329G>T",
"hgvs_p": "p.Gly443Gly",
"transcript": "ENST00000878174.1",
"protein_id": "ENSP00000548233.1",
"transcript_support_level": null,
"aa_start": 443,
"aa_end": null,
"aa_length": 489,
"cds_start": 1329,
"cds_end": null,
"cds_length": 1470,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878174.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1275G>T",
"hgvs_p": "p.Gly425Gly",
"transcript": "ENST00000878173.1",
"protein_id": "ENSP00000548232.1",
"transcript_support_level": null,
"aa_start": 425,
"aa_end": null,
"aa_length": 471,
"cds_start": 1275,
"cds_end": null,
"cds_length": 1416,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878173.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1242G>T",
"hgvs_p": "p.Gly414Gly",
"transcript": "ENST00000878172.1",
"protein_id": "ENSP00000548231.1",
"transcript_support_level": null,
"aa_start": 414,
"aa_end": null,
"aa_length": 460,
"cds_start": 1242,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878172.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1221G>T",
"hgvs_p": "p.Gly407Gly",
"transcript": "NM_001301044.2",
"protein_id": "NP_001287973.1",
"transcript_support_level": null,
"aa_start": 407,
"aa_end": null,
"aa_length": 453,
"cds_start": 1221,
"cds_end": null,
"cds_length": 1362,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001301044.2"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1191G>T",
"hgvs_p": "p.Gly397Gly",
"transcript": "NM_001301045.2",
"protein_id": "NP_001287974.1",
"transcript_support_level": null,
"aa_start": 397,
"aa_end": null,
"aa_length": 443,
"cds_start": 1191,
"cds_end": null,
"cds_length": 1332,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001301045.2"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1188G>T",
"hgvs_p": "p.Gly396Gly",
"transcript": "NM_014333.4",
"protein_id": "NP_055148.3",
"transcript_support_level": null,
"aa_start": 396,
"aa_end": null,
"aa_length": 442,
"cds_start": 1188,
"cds_end": null,
"cds_length": 1329,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_014333.4"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1158G>T",
"hgvs_p": "p.Gly386Gly",
"transcript": "ENST00000930502.1",
"protein_id": "ENSP00000600561.1",
"transcript_support_level": null,
"aa_start": 386,
"aa_end": null,
"aa_length": 432,
"cds_start": 1158,
"cds_end": null,
"cds_length": 1299,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930502.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1104G>T",
"hgvs_p": "p.Gly368Gly",
"transcript": "NM_001098517.2",
"protein_id": "NP_001091987.1",
"transcript_support_level": null,
"aa_start": 368,
"aa_end": null,
"aa_length": 414,
"cds_start": 1104,
"cds_end": null,
"cds_length": 1245,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001098517.2"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.981G>T",
"hgvs_p": "p.Gly327Gly",
"transcript": "ENST00000612235.4",
"protein_id": "ENSP00000483648.1",
"transcript_support_level": 5,
"aa_start": 327,
"aa_end": null,
"aa_length": 346,
"cds_start": 981,
"cds_end": null,
"cds_length": 1041,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000612235.4"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1293G>T",
"hgvs_p": "p.Gly431Gly",
"transcript": "XM_017017457.3",
"protein_id": "XP_016872946.1",
"transcript_support_level": null,
"aa_start": 431,
"aa_end": null,
"aa_length": 477,
"cds_start": 1293,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017017457.3"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1239G>T",
"hgvs_p": "p.Gly413Gly",
"transcript": "XM_047426690.1",
"protein_id": "XP_047282646.1",
"transcript_support_level": null,
"aa_start": 413,
"aa_end": null,
"aa_length": 459,
"cds_start": 1239,
"cds_end": null,
"cds_length": 1380,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047426690.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1209G>T",
"hgvs_p": "p.Gly403Gly",
"transcript": "XM_047426691.1",
"protein_id": "XP_047282647.1",
"transcript_support_level": null,
"aa_start": 403,
"aa_end": null,
"aa_length": 449,
"cds_start": 1209,
"cds_end": null,
"cds_length": 1350,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047426691.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADM1",
"gene_hgnc_id": 5951,
"hgvs_c": "c.1206G>T",
"hgvs_p": "p.Gly402Gly",
"transcript": "XM_047426692.1",
"protein_id": "XP_047282648.1",
"transcript_support_level": null,
"aa_start": 402,
"aa_end": null,
"aa_length": 448,
"cds_start": 1206,
"cds_end": null,
"cds_length": 1347,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047426692.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
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{
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"BP7"
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"verdict": "Likely_benign",
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"clinvar_disease": "",
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}
],
"message": null
}