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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-116830787-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=116830787&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 116830787,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_000040.3",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "NM_000040.3",
"protein_id": "NP_000031.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 117,
"cdna_end": null,
"cdna_length": 535,
"mane_select": "ENST00000227667.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000040.3"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000227667.8",
"protein_id": "ENSP00000227667.2",
"transcript_support_level": 1,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 117,
"cdna_end": null,
"cdna_length": 535,
"mane_select": "NM_000040.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000227667.8"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.124G>C",
"hgvs_p": "p.Glu42Gln",
"transcript": "ENST00000630701.1",
"protein_id": "ENSP00000486182.1",
"transcript_support_level": 1,
"aa_start": 42,
"aa_end": null,
"aa_length": 117,
"cds_start": 124,
"cds_end": null,
"cds_length": 354,
"cdna_start": 124,
"cdna_end": null,
"cdna_length": 541,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000630701.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.127G>C",
"hgvs_p": "p.Glu43Gln",
"transcript": "ENST00000863804.1",
"protein_id": "ENSP00000533863.1",
"transcript_support_level": null,
"aa_start": 43,
"aa_end": null,
"aa_length": 118,
"cds_start": 127,
"cds_end": null,
"cds_length": 357,
"cdna_start": 173,
"cdna_end": null,
"cdna_length": 587,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863804.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.124G>C",
"hgvs_p": "p.Glu42Gln",
"transcript": "ENST00000375345.3",
"protein_id": "ENSP00000364494.1",
"transcript_support_level": 5,
"aa_start": 42,
"aa_end": null,
"aa_length": 117,
"cds_start": 124,
"cds_end": null,
"cds_length": 354,
"cdna_start": 186,
"cdna_end": null,
"cdna_length": 604,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000375345.3"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863784.1",
"protein_id": "ENSP00000533843.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 269,
"cdna_end": null,
"cdna_length": 686,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863784.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863785.1",
"protein_id": "ENSP00000533844.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 196,
"cdna_end": null,
"cdna_length": 609,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863785.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863786.1",
"protein_id": "ENSP00000533845.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 505,
"cdna_end": null,
"cdna_length": 921,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863786.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863787.1",
"protein_id": "ENSP00000533846.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 769,
"cdna_end": null,
"cdna_length": 1182,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863787.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863788.1",
"protein_id": "ENSP00000533847.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 642,
"cdna_end": null,
"cdna_length": 1055,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863788.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863789.1",
"protein_id": "ENSP00000533848.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 1608,
"cdna_end": null,
"cdna_length": 2028,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863789.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863790.1",
"protein_id": "ENSP00000533849.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 826,
"cdna_end": null,
"cdna_length": 1245,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863790.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863791.1",
"protein_id": "ENSP00000533850.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 666,
"cdna_end": null,
"cdna_length": 1082,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863791.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863792.1",
"protein_id": "ENSP00000533851.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 371,
"cdna_end": null,
"cdna_length": 1060,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863792.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863793.1",
"protein_id": "ENSP00000533852.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 245,
"cdna_end": null,
"cdna_length": 662,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863793.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863794.1",
"protein_id": "ENSP00000533853.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 272,
"cdna_end": null,
"cdna_length": 702,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863794.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863795.1",
"protein_id": "ENSP00000533854.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 256,
"cdna_end": null,
"cdna_length": 677,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863795.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863796.1",
"protein_id": "ENSP00000533855.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 136,
"cdna_end": null,
"cdna_length": 553,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863796.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863798.1",
"protein_id": "ENSP00000533857.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 523,
"cdna_end": null,
"cdna_length": 942,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863798.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863801.1",
"protein_id": "ENSP00000533860.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 222,
"cdna_end": null,
"cdna_length": 639,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863801.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863802.1",
"protein_id": "ENSP00000533861.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 502,
"cdna_end": null,
"cdna_length": 919,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863802.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "APOC3",
"gene_hgnc_id": 610,
"hgvs_c": "c.70G>C",
"hgvs_p": "p.Glu24Gln",
"transcript": "ENST00000863803.1",
"protein_id": "ENSP00000533862.1",
"transcript_support_level": null,
"aa_start": 24,
"aa_end": null,
"aa_length": 99,
"cds_start": 70,
"cds_end": null,
"cds_length": 300,
"cdna_start": 246,
"cdna_end": null,
"cdna_length": 663,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863803.1"
},
{
"aa_ref": "E",
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{
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}
],
"message": null
}