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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-116892318-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=116892318&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 116892318,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_001366686.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "NM_001366686.3",
"protein_id": "NP_001353615.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1369,
"cds_start": null,
"cds_end": null,
"cds_length": 4110,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000445177.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001366686.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "ENST00000445177.6",
"protein_id": "ENSP00000391295.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1369,
"cds_start": null,
"cds_end": null,
"cds_length": 4110,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001366686.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000445177.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "ENST00000446921.6",
"protein_id": "ENSP00000390442.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1261,
"cds_start": null,
"cds_end": null,
"cds_length": 3786,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000446921.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "n.*389+3935C>G",
"hgvs_p": null,
"transcript": "ENST00000415541.5",
"protein_id": "ENSP00000392761.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000415541.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "ENST00000923916.1",
"protein_id": "ENSP00000593975.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1403,
"cds_start": null,
"cds_end": null,
"cds_length": 4212,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923916.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "ENST00000954062.1",
"protein_id": "ENSP00000624121.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1369,
"cds_start": null,
"cds_end": null,
"cds_length": 4110,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954062.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "ENST00000923914.1",
"protein_id": "ENSP00000593973.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1364,
"cds_start": null,
"cds_end": null,
"cds_length": 4095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923914.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "ENST00000954064.1",
"protein_id": "ENSP00000624123.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1337,
"cds_start": null,
"cds_end": null,
"cds_length": 4014,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954064.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "NM_025164.6",
"protein_id": "NP_079440.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1321,
"cds_start": null,
"cds_end": null,
"cds_length": 3966,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_025164.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "ENST00000375300.6",
"protein_id": "ENSP00000364449.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 1321,
"cds_start": null,
"cds_end": null,
"cds_length": 3966,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000375300.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "ENST00000923910.1",
"protein_id": "ENSP00000593969.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1321,
"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 23,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
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"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "ENST00000954063.1",
"protein_id": "ENSP00000624122.1",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000954063.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 24,
"intron_rank": 6,
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"gene_symbol": "SIK3",
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"hgvs_c": "c.865+3935C>G",
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"transcript": "ENST00000954067.1",
"protein_id": "ENSP00000624126.1",
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "SIK3",
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"hgvs_c": "c.865+3935C>G",
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"biotype": "protein_coding",
"feature": "ENST00000923915.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "ENST00000878032.1",
"protein_id": "ENSP00000548091.1",
"transcript_support_level": null,
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"feature": "ENST00000878032.1"
},
{
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],
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"gene_symbol": "SIK3",
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"hgvs_c": "c.865+3935C>G",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 23,
"intron_rank": 6,
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"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "ENST00000923913.1",
"protein_id": "ENSP00000593972.1",
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"feature": "ENST00000923913.1"
},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "NM_001281749.3",
"protein_id": "NP_001268678.1",
"transcript_support_level": null,
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},
{
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],
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"intron_rank": 6,
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"gene_symbol": "SIK3",
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"hgvs_c": "c.865+3935C>G",
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},
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"strand": false,
"consequences": [
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],
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"intron_rank": 6,
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"gene_symbol": "SIK3",
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},
{
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"strand": false,
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],
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"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
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"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "ENST00000954065.1",
"protein_id": "ENSP00000624124.1",
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954065.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SIK3",
"gene_hgnc_id": 29165,
"hgvs_c": "c.865+3935C>G",
"hgvs_p": null,
"transcript": "ENST00000923918.1",
"protein_id": "ENSP00000593977.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1181,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923918.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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