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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-118534089-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=118534089&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 118534089,
"ref": "G",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_001318755.2",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.897G>C",
"hgvs_p": "p.Pro299Pro",
"transcript": "NM_032780.4",
"protein_id": "NP_116169.2",
"transcript_support_level": null,
"aa_start": 299,
"aa_end": null,
"aa_length": 366,
"cds_start": 897,
"cds_end": null,
"cds_length": 1101,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000313236.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032780.4"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.897G>C",
"hgvs_p": "p.Pro299Pro",
"transcript": "ENST00000313236.10",
"protein_id": "ENSP00000315635.5",
"transcript_support_level": 1,
"aa_start": 299,
"aa_end": null,
"aa_length": 366,
"cds_start": 897,
"cds_end": null,
"cds_length": 1101,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_032780.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000313236.10"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.897G>C",
"hgvs_p": "p.Pro299Pro",
"transcript": "ENST00000533102.5",
"protein_id": "ENSP00000431548.1",
"transcript_support_level": 1,
"aa_start": 299,
"aa_end": null,
"aa_length": 381,
"cds_start": 897,
"cds_end": null,
"cds_length": 1146,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000533102.5"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.765G>C",
"hgvs_p": "p.Pro255Pro",
"transcript": "ENST00000359862.8",
"protein_id": "ENSP00000352924.4",
"transcript_support_level": 1,
"aa_start": 255,
"aa_end": null,
"aa_length": 322,
"cds_start": 765,
"cds_end": null,
"cds_length": 969,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000359862.8"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.945G>C",
"hgvs_p": "p.Pro315Pro",
"transcript": "ENST00000947270.1",
"protein_id": "ENSP00000617329.1",
"transcript_support_level": null,
"aa_start": 315,
"aa_end": null,
"aa_length": 382,
"cds_start": 945,
"cds_end": null,
"cds_length": 1149,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000947270.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.897G>C",
"hgvs_p": "p.Pro299Pro",
"transcript": "NM_001318755.2",
"protein_id": "NP_001305684.1",
"transcript_support_level": null,
"aa_start": 299,
"aa_end": null,
"aa_length": 381,
"cds_start": 897,
"cds_end": null,
"cds_length": 1146,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001318755.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.918G>C",
"hgvs_p": "p.Pro306Pro",
"transcript": "ENST00000872239.1",
"protein_id": "ENSP00000542298.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 373,
"cds_start": 918,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000872239.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.906G>C",
"hgvs_p": "p.Pro302Pro",
"transcript": "ENST00000872242.1",
"protein_id": "ENSP00000542301.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 369,
"cds_start": 906,
"cds_end": null,
"cds_length": 1110,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000872242.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.897G>C",
"hgvs_p": "p.Pro299Pro",
"transcript": "ENST00000872237.1",
"protein_id": "ENSP00000542296.1",
"transcript_support_level": null,
"aa_start": 299,
"aa_end": null,
"aa_length": 366,
"cds_start": 897,
"cds_end": null,
"cds_length": 1101,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000872237.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.897G>C",
"hgvs_p": "p.Pro299Pro",
"transcript": "ENST00000931619.1",
"protein_id": "ENSP00000601678.1",
"transcript_support_level": null,
"aa_start": 299,
"aa_end": null,
"aa_length": 366,
"cds_start": 897,
"cds_end": null,
"cds_length": 1101,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931619.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.897G>C",
"hgvs_p": "p.Pro299Pro",
"transcript": "NM_001144037.2",
"protein_id": "NP_001137509.1",
"transcript_support_level": null,
"aa_start": 299,
"aa_end": null,
"aa_length": 351,
"cds_start": 897,
"cds_end": null,
"cds_length": 1056,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001144037.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.897G>C",
"hgvs_p": "p.Pro299Pro",
"transcript": "ENST00000354284.8",
"protein_id": "ENSP00000346237.4",
"transcript_support_level": 2,
"aa_start": 299,
"aa_end": null,
"aa_length": 351,
"cds_start": 897,
"cds_end": null,
"cds_length": 1056,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000354284.8"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.801G>C",
"hgvs_p": "p.Pro267Pro",
"transcript": "ENST00000947267.1",
"protein_id": "ENSP00000617326.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 334,
"cds_start": 801,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000947267.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.786G>C",
"hgvs_p": "p.Pro262Pro",
"transcript": "ENST00000931624.1",
"protein_id": "ENSP00000601683.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 329,
"cds_start": 786,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931624.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.765G>C",
"hgvs_p": "p.Pro255Pro",
"transcript": "NM_001144034.2",
"protein_id": "NP_001137506.1",
"transcript_support_level": null,
"aa_start": 255,
"aa_end": null,
"aa_length": 322,
"cds_start": 765,
"cds_end": null,
"cds_length": 969,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001144034.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.765G>C",
"hgvs_p": "p.Pro255Pro",
"transcript": "NM_001144035.2",
"protein_id": "NP_001137507.1",
"transcript_support_level": null,
"aa_start": 255,
"aa_end": null,
"aa_length": 322,
"cds_start": 765,
"cds_end": null,
"cds_length": 969,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001144035.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.765G>C",
"hgvs_p": "p.Pro255Pro",
"transcript": "ENST00000411589.6",
"protein_id": "ENSP00000411882.2",
"transcript_support_level": 2,
"aa_start": 255,
"aa_end": null,
"aa_length": 322,
"cds_start": 765,
"cds_end": null,
"cds_length": 969,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000411589.6"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.765G>C",
"hgvs_p": "p.Pro255Pro",
"transcript": "ENST00000524725.5",
"protein_id": "ENSP00000431205.1",
"transcript_support_level": 2,
"aa_start": 255,
"aa_end": null,
"aa_length": 322,
"cds_start": 765,
"cds_end": null,
"cds_length": 969,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000524725.5"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.765G>C",
"hgvs_p": "p.Pro255Pro",
"transcript": "ENST00000931620.1",
"protein_id": "ENSP00000601679.1",
"transcript_support_level": null,
"aa_start": 255,
"aa_end": null,
"aa_length": 321,
"cds_start": 765,
"cds_end": null,
"cds_length": 966,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931620.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.765G>C",
"hgvs_p": "p.Pro255Pro",
"transcript": "ENST00000947271.1",
"protein_id": "ENSP00000617330.1",
"transcript_support_level": null,
"aa_start": 255,
"aa_end": null,
"aa_length": 321,
"cds_start": 765,
"cds_end": null,
"cds_length": 966,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000947271.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.765G>C",
"hgvs_p": "p.Pro255Pro",
"transcript": "NM_001144038.2",
"protein_id": "NP_001137510.1",
"transcript_support_level": null,
"aa_start": 255,
"aa_end": null,
"aa_length": 306,
"cds_start": 765,
"cds_end": null,
"cds_length": 921,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001144038.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM25",
"gene_hgnc_id": 25890,
"hgvs_c": "c.765G>C",
"hgvs_p": "p.Pro255Pro",
"transcript": "ENST00000442938.6",
"protein_id": "ENSP00000416071.2",
"transcript_support_level": 2,
"aa_start": 255,
"aa_end": null,
"aa_length": 306,
"cds_start": 765,
"cds_end": null,
"cds_length": 921,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000442938.6"
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],
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"computational_prediction_selected": "Benign",
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"splice_prediction_selected": "Benign",
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"bayesdelnoaf_score": -0.58,
"bayesdelnoaf_prediction": "Benign",
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"phylop100way_prediction": "Benign",
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{
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"BP7"
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"verdict": "Likely_benign",
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],
"clinvar_disease": "",
"clinvar_classification": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"phenotype_combined": null,
"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}