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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-119015869-AG-TC (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=119015869&ref=AG&alt=TC&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "RPS25",
          "hgnc_id": 10413,
          "hgvs_c": "c.353_354delCTinsGA",
          "hgvs_p": "p.Ala118Gly",
          "inheritance_mode": "AD",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "NM_001028.3",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "downstream_gene_variant"
          ],
          "gene_symbol": "CENATAC",
          "hgnc_id": 30460,
          "hgvs_c": "c.*271_*272delAGinsTC",
          "hgvs_p": null,
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "NM_198489.3",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "",
      "acmg_score": 0,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "TC",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "11",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 125,
          "aa_ref": "A",
          "aa_start": 118,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 483,
          "cdna_start": 413,
          "cds_end": null,
          "cds_length": 378,
          "cds_start": 353,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001028.3",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "c.353_354delCTinsGA",
          "hgvs_p": "p.Ala118Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000527673.2",
          "protein_coding": true,
          "protein_id": "NP_001019.1",
          "strand": false,
          "transcript": "NM_001028.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 125,
          "aa_ref": "A",
          "aa_start": 118,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 483,
          "cdna_start": 413,
          "cds_end": null,
          "cds_length": 378,
          "cds_start": 353,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000527673.2",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "c.353_354delCTinsGA",
          "hgvs_p": "p.Ala118Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001028.3",
          "protein_coding": true,
          "protein_id": "ENSP00000435096.1",
          "strand": false,
          "transcript": "ENST00000527673.2",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 126,
          "aa_ref": "A",
          "aa_start": 119,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1076,
          "cdna_start": 797,
          "cds_end": null,
          "cds_length": 381,
          "cds_start": 356,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000937795.1",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "c.356_357delCTinsGA",
          "hgvs_p": "p.Ala119Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000607854.1",
          "strand": false,
          "transcript": "ENST00000937795.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 125,
          "aa_ref": "A",
          "aa_start": 118,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 568,
          "cdna_start": 414,
          "cds_end": null,
          "cds_length": 378,
          "cds_start": 353,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000891655.1",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "c.353_354delCTinsGA",
          "hgvs_p": "p.Ala118Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561714.1",
          "strand": false,
          "transcript": "ENST00000891655.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 125,
          "aa_ref": "A",
          "aa_start": 118,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 530,
          "cdna_start": 419,
          "cds_end": null,
          "cds_length": 378,
          "cds_start": 353,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000937799.1",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "c.353_354delCTinsGA",
          "hgvs_p": "p.Ala118Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000607858.1",
          "strand": false,
          "transcript": "ENST00000937799.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 124,
          "aa_ref": "A",
          "aa_start": 117,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 593,
          "cdna_start": 437,
          "cds_end": null,
          "cds_length": 375,
          "cds_start": 350,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000937798.1",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "c.350_351delCTinsGA",
          "hgvs_p": "p.Ala117Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000607857.1",
          "strand": false,
          "transcript": "ENST00000937798.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 124,
          "aa_ref": "A",
          "aa_start": 117,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 827,
          "cdna_start": 752,
          "cds_end": null,
          "cds_length": 375,
          "cds_start": 350,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000942362.1",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "c.350_351delCTinsGA",
          "hgvs_p": "p.Ala117Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000612421.1",
          "strand": false,
          "transcript": "ENST00000942362.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 122,
          "aa_ref": "A",
          "aa_start": 115,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 828,
          "cdna_start": 749,
          "cds_end": null,
          "cds_length": 369,
          "cds_start": 344,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000937796.1",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "c.344_345delCTinsGA",
          "hgvs_p": "p.Ala115Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000607855.1",
          "strand": false,
          "transcript": "ENST00000937796.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 118,
          "aa_ref": "A",
          "aa_start": 111,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 764,
          "cdna_start": 689,
          "cds_end": null,
          "cds_length": 357,
          "cds_start": 332,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000937797.1",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "c.332_333delCTinsGA",
          "hgvs_p": "p.Ala111Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000607856.1",
          "strand": false,
          "transcript": "ENST00000937797.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 93,
          "aa_ref": "A",
          "aa_start": 86,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 720,
          "cdna_start": 648,
          "cds_end": null,
          "cds_length": 282,
          "cds_start": 257,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000891654.1",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "c.257_258delCTinsGA",
          "hgvs_p": "p.Ala86Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561713.1",
          "strand": false,
          "transcript": "ENST00000891654.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 93,
          "aa_ref": "A",
          "aa_start": 86,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 474,
          "cdna_start": 317,
          "cds_end": null,
          "cds_length": 282,
          "cds_start": 257,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000937800.1",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "c.257_258delCTinsGA",
          "hgvs_p": "p.Ala86Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000607859.1",
          "strand": false,
          "transcript": "ENST00000937800.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 711,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 5,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000527791.5",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "n.*121_*122delCTinsGA",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000436193.1",
          "strand": false,
          "transcript": "ENST00000527791.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1462,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 3,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000527853.1",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "n.1400_1401delCTinsGA",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000527853.1",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 508,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 5,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000532567.5",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "n.*266_*267delCTinsGA",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000431634.1",
          "strand": false,
          "transcript": "ENST00000532567.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 711,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_count": 5,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000527791.5",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "n.*121_*122delCTinsGA",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000436193.1",
          "strand": false,
          "transcript": "ENST00000527791.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 508,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_count": 5,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000532567.5",
          "gene_hgnc_id": 10413,
          "gene_symbol": "RPS25",
          "hgvs_c": "n.*266_*267delCTinsGA",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000431634.1",
          "strand": false,
          "transcript": "ENST00000532567.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 332,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1254,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 999,
          "cds_start": null,
          "consequences": [
            "downstream_gene_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_198489.3",
          "gene_hgnc_id": 30460,
          "gene_symbol": "CENATAC",
          "hgvs_c": "c.*271_*272delAGinsTC",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000334418.6",
          "protein_coding": true,
          "protein_id": "NP_940891.1",
          "strand": true,
          "transcript": "NM_198489.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 332,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1254,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 999,
          "cds_start": null,
          "consequences": [
            "downstream_gene_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000334418.6",
          "gene_hgnc_id": 30460,
          "gene_symbol": "CENATAC",
          "hgvs_c": "c.*271_*272delAGinsTC",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_198489.3",
          "protein_coding": true,
          "protein_id": "ENSP00000334767.1",
          "strand": true,
          "transcript": "ENST00000334418.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1295,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "downstream_gene_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000526463.5",
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.