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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-11964600-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=11964600&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 11964600,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001330220.3",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.917A>G",
"hgvs_p": "p.Asp306Gly",
"transcript": "NM_001018057.2",
"protein_id": "NP_001018067.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 350,
"cds_start": 917,
"cds_end": null,
"cds_length": 1053,
"cdna_start": 961,
"cdna_end": null,
"cdna_length": 2525,
"mane_select": "ENST00000683431.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001018057.2"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.917A>G",
"hgvs_p": "p.Asp306Gly",
"transcript": "ENST00000683431.1",
"protein_id": "ENSP00000506835.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 350,
"cds_start": 917,
"cds_end": null,
"cds_length": 1053,
"cdna_start": 961,
"cdna_end": null,
"cdna_length": 2525,
"mane_select": "NM_001018057.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000683431.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.917A>G",
"hgvs_p": "p.Asp306Gly",
"transcript": "ENST00000326932.8",
"protein_id": "ENSP00000314910.4",
"transcript_support_level": 1,
"aa_start": 306,
"aa_end": null,
"aa_length": 350,
"cds_start": 917,
"cds_end": null,
"cds_length": 1053,
"cdna_start": 1142,
"cdna_end": null,
"cdna_length": 2636,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000326932.8"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.917A>G",
"hgvs_p": "p.Asp306Gly",
"transcript": "ENST00000396505.7",
"protein_id": "ENSP00000379762.2",
"transcript_support_level": 1,
"aa_start": 306,
"aa_end": null,
"aa_length": 350,
"cds_start": 917,
"cds_end": null,
"cds_length": 1053,
"cdna_start": 1156,
"cdna_end": null,
"cdna_length": 9549,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396505.7"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.1166A>G",
"hgvs_p": "p.Asp389Gly",
"transcript": "ENST00000903527.1",
"protein_id": "ENSP00000573586.1",
"transcript_support_level": null,
"aa_start": 389,
"aa_end": null,
"aa_length": 433,
"cds_start": 1166,
"cds_end": null,
"cds_length": 1302,
"cdna_start": 1203,
"cdna_end": null,
"cdna_length": 2696,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903527.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.1166A>G",
"hgvs_p": "p.Asp389Gly",
"transcript": "ENST00000958801.1",
"protein_id": "ENSP00000628860.1",
"transcript_support_level": null,
"aa_start": 389,
"aa_end": null,
"aa_length": 433,
"cds_start": 1166,
"cds_end": null,
"cds_length": 1302,
"cdna_start": 1359,
"cdna_end": null,
"cdna_length": 2853,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958801.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.1088A>G",
"hgvs_p": "p.Asp363Gly",
"transcript": "ENST00000958821.1",
"protein_id": "ENSP00000628880.1",
"transcript_support_level": null,
"aa_start": 363,
"aa_end": null,
"aa_length": 407,
"cds_start": 1088,
"cds_end": null,
"cds_length": 1224,
"cdna_start": 1095,
"cdna_end": null,
"cdna_length": 2589,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958821.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.1085A>G",
"hgvs_p": "p.Asp362Gly",
"transcript": "ENST00000903519.1",
"protein_id": "ENSP00000573578.1",
"transcript_support_level": null,
"aa_start": 362,
"aa_end": null,
"aa_length": 406,
"cds_start": 1085,
"cds_end": null,
"cds_length": 1221,
"cdna_start": 1269,
"cdna_end": null,
"cdna_length": 2763,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903519.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.1085A>G",
"hgvs_p": "p.Asp362Gly",
"transcript": "ENST00000958809.1",
"protein_id": "ENSP00000628868.1",
"transcript_support_level": null,
"aa_start": 362,
"aa_end": null,
"aa_length": 406,
"cds_start": 1085,
"cds_end": null,
"cds_length": 1221,
"cdna_start": 1169,
"cdna_end": null,
"cdna_length": 2663,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958809.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.1085A>G",
"hgvs_p": "p.Asp362Gly",
"transcript": "ENST00000958813.1",
"protein_id": "ENSP00000628872.1",
"transcript_support_level": null,
"aa_start": 362,
"aa_end": null,
"aa_length": 406,
"cds_start": 1085,
"cds_end": null,
"cds_length": 1221,
"cdna_start": 1267,
"cdna_end": null,
"cdna_length": 2761,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958813.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.1085A>G",
"hgvs_p": "p.Asp362Gly",
"transcript": "ENST00000958819.1",
"protein_id": "ENSP00000628878.1",
"transcript_support_level": null,
"aa_start": 362,
"aa_end": null,
"aa_length": 406,
"cds_start": 1085,
"cds_end": null,
"cds_length": 1221,
"cdna_start": 1129,
"cdna_end": null,
"cdna_length": 2622,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958819.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.998A>G",
"hgvs_p": "p.Asp333Gly",
"transcript": "ENST00000958798.1",
"protein_id": "ENSP00000628857.1",
"transcript_support_level": null,
"aa_start": 333,
"aa_end": null,
"aa_length": 377,
"cds_start": 998,
"cds_end": null,
"cds_length": 1134,
"cdna_start": 1221,
"cdna_end": null,
"cdna_length": 2719,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958798.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.998A>G",
"hgvs_p": "p.Asp333Gly",
"transcript": "ENST00000958803.1",
"protein_id": "ENSP00000628862.1",
"transcript_support_level": null,
"aa_start": 333,
"aa_end": null,
"aa_length": 377,
"cds_start": 998,
"cds_end": null,
"cds_length": 1134,
"cdna_start": 1179,
"cdna_end": null,
"cdna_length": 2672,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958803.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.998A>G",
"hgvs_p": "p.Asp333Gly",
"transcript": "ENST00000958815.1",
"protein_id": "ENSP00000628874.1",
"transcript_support_level": null,
"aa_start": 333,
"aa_end": null,
"aa_length": 377,
"cds_start": 998,
"cds_end": null,
"cds_length": 1134,
"cdna_start": 1084,
"cdna_end": null,
"cdna_length": 2579,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958815.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.998A>G",
"hgvs_p": "p.Asp333Gly",
"transcript": "ENST00000958818.1",
"protein_id": "ENSP00000628877.1",
"transcript_support_level": null,
"aa_start": 333,
"aa_end": null,
"aa_length": 377,
"cds_start": 998,
"cds_end": null,
"cds_length": 1134,
"cdna_start": 1042,
"cdna_end": null,
"cdna_length": 2535,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958818.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.983A>G",
"hgvs_p": "p.Asp328Gly",
"transcript": "ENST00000958802.1",
"protein_id": "ENSP00000628861.1",
"transcript_support_level": null,
"aa_start": 328,
"aa_end": null,
"aa_length": 372,
"cds_start": 983,
"cds_end": null,
"cds_length": 1119,
"cdna_start": 1166,
"cdna_end": null,
"cdna_length": 2660,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958802.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.983A>G",
"hgvs_p": "p.Asp328Gly",
"transcript": "ENST00000958817.1",
"protein_id": "ENSP00000628876.1",
"transcript_support_level": null,
"aa_start": 328,
"aa_end": null,
"aa_length": 372,
"cds_start": 983,
"cds_end": null,
"cds_length": 1119,
"cdna_start": 1027,
"cdna_end": null,
"cdna_length": 2521,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958817.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.980A>G",
"hgvs_p": "p.Asp327Gly",
"transcript": "ENST00000958804.1",
"protein_id": "ENSP00000628863.1",
"transcript_support_level": null,
"aa_start": 327,
"aa_end": null,
"aa_length": 371,
"cds_start": 980,
"cds_end": null,
"cds_length": 1116,
"cdna_start": 1131,
"cdna_end": null,
"cdna_length": 2625,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958804.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.959A>G",
"hgvs_p": "p.Asp320Gly",
"transcript": "NM_001330220.3",
"protein_id": "NP_001317149.1",
"transcript_support_level": null,
"aa_start": 320,
"aa_end": null,
"aa_length": 364,
"cds_start": 959,
"cds_end": null,
"cds_length": 1095,
"cdna_start": 1150,
"cdna_end": null,
"cdna_length": 2714,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001330220.3"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.959A>G",
"hgvs_p": "p.Asp320Gly",
"transcript": "ENST00000525493.5",
"protein_id": "ENSP00000433112.1",
"transcript_support_level": 2,
"aa_start": 320,
"aa_end": null,
"aa_length": 364,
"cds_start": 959,
"cds_end": null,
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"cdna_start": 1117,
"cdna_end": null,
"cdna_length": 1326,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000525493.5"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.959A>G",
"hgvs_p": "p.Asp320Gly",
"transcript": "ENST00000903516.1",
"protein_id": "ENSP00000573575.1",
"transcript_support_level": null,
"aa_start": 320,
"aa_end": null,
"aa_length": 364,
"cds_start": 959,
"cds_end": null,
"cds_length": 1095,
"cdna_start": 1186,
"cdna_end": null,
"cdna_length": 2740,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903516.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.959A>G",
"hgvs_p": "p.Asp320Gly",
"transcript": "ENST00000903523.1",
"protein_id": "ENSP00000573582.1",
"transcript_support_level": null,
"aa_start": 320,
"aa_end": null,
"aa_length": 364,
"cds_start": 959,
"cds_end": null,
"cds_length": 1095,
"cdna_start": 1053,
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}
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}