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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-11964657-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=11964657&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 11964657,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001330220.3",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.860C>T",
"hgvs_p": "p.Thr287Ile",
"transcript": "NM_001018057.2",
"protein_id": "NP_001018067.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 350,
"cds_start": 860,
"cds_end": null,
"cds_length": 1053,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000683431.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001018057.2"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.860C>T",
"hgvs_p": "p.Thr287Ile",
"transcript": "ENST00000683431.1",
"protein_id": "ENSP00000506835.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 350,
"cds_start": 860,
"cds_end": null,
"cds_length": 1053,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001018057.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000683431.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.860C>T",
"hgvs_p": "p.Thr287Ile",
"transcript": "ENST00000326932.8",
"protein_id": "ENSP00000314910.4",
"transcript_support_level": 1,
"aa_start": 287,
"aa_end": null,
"aa_length": 350,
"cds_start": 860,
"cds_end": null,
"cds_length": 1053,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000326932.8"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.860C>T",
"hgvs_p": "p.Thr287Ile",
"transcript": "ENST00000396505.7",
"protein_id": "ENSP00000379762.2",
"transcript_support_level": 1,
"aa_start": 287,
"aa_end": null,
"aa_length": 350,
"cds_start": 860,
"cds_end": null,
"cds_length": 1053,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396505.7"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.1109C>T",
"hgvs_p": "p.Thr370Ile",
"transcript": "ENST00000903527.1",
"protein_id": "ENSP00000573586.1",
"transcript_support_level": null,
"aa_start": 370,
"aa_end": null,
"aa_length": 433,
"cds_start": 1109,
"cds_end": null,
"cds_length": 1302,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903527.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.1109C>T",
"hgvs_p": "p.Thr370Ile",
"transcript": "ENST00000958801.1",
"protein_id": "ENSP00000628860.1",
"transcript_support_level": null,
"aa_start": 370,
"aa_end": null,
"aa_length": 433,
"cds_start": 1109,
"cds_end": null,
"cds_length": 1302,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958801.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.1031C>T",
"hgvs_p": "p.Thr344Ile",
"transcript": "ENST00000958821.1",
"protein_id": "ENSP00000628880.1",
"transcript_support_level": null,
"aa_start": 344,
"aa_end": null,
"aa_length": 407,
"cds_start": 1031,
"cds_end": null,
"cds_length": 1224,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958821.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.1028C>T",
"hgvs_p": "p.Thr343Ile",
"transcript": "ENST00000903519.1",
"protein_id": "ENSP00000573578.1",
"transcript_support_level": null,
"aa_start": 343,
"aa_end": null,
"aa_length": 406,
"cds_start": 1028,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903519.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.1028C>T",
"hgvs_p": "p.Thr343Ile",
"transcript": "ENST00000958809.1",
"protein_id": "ENSP00000628868.1",
"transcript_support_level": null,
"aa_start": 343,
"aa_end": null,
"aa_length": 406,
"cds_start": 1028,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958809.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.1028C>T",
"hgvs_p": "p.Thr343Ile",
"transcript": "ENST00000958813.1",
"protein_id": "ENSP00000628872.1",
"transcript_support_level": null,
"aa_start": 343,
"aa_end": null,
"aa_length": 406,
"cds_start": 1028,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958813.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.1028C>T",
"hgvs_p": "p.Thr343Ile",
"transcript": "ENST00000958819.1",
"protein_id": "ENSP00000628878.1",
"transcript_support_level": null,
"aa_start": 343,
"aa_end": null,
"aa_length": 406,
"cds_start": 1028,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958819.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.941C>T",
"hgvs_p": "p.Thr314Ile",
"transcript": "ENST00000958798.1",
"protein_id": "ENSP00000628857.1",
"transcript_support_level": null,
"aa_start": 314,
"aa_end": null,
"aa_length": 377,
"cds_start": 941,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958798.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.941C>T",
"hgvs_p": "p.Thr314Ile",
"transcript": "ENST00000958803.1",
"protein_id": "ENSP00000628862.1",
"transcript_support_level": null,
"aa_start": 314,
"aa_end": null,
"aa_length": 377,
"cds_start": 941,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958803.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.941C>T",
"hgvs_p": "p.Thr314Ile",
"transcript": "ENST00000958815.1",
"protein_id": "ENSP00000628874.1",
"transcript_support_level": null,
"aa_start": 314,
"aa_end": null,
"aa_length": 377,
"cds_start": 941,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958815.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.941C>T",
"hgvs_p": "p.Thr314Ile",
"transcript": "ENST00000958818.1",
"protein_id": "ENSP00000628877.1",
"transcript_support_level": null,
"aa_start": 314,
"aa_end": null,
"aa_length": 377,
"cds_start": 941,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958818.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.926C>T",
"hgvs_p": "p.Thr309Ile",
"transcript": "ENST00000958802.1",
"protein_id": "ENSP00000628861.1",
"transcript_support_level": null,
"aa_start": 309,
"aa_end": null,
"aa_length": 372,
"cds_start": 926,
"cds_end": null,
"cds_length": 1119,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958802.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.926C>T",
"hgvs_p": "p.Thr309Ile",
"transcript": "ENST00000958817.1",
"protein_id": "ENSP00000628876.1",
"transcript_support_level": null,
"aa_start": 309,
"aa_end": null,
"aa_length": 372,
"cds_start": 926,
"cds_end": null,
"cds_length": 1119,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958817.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.923C>T",
"hgvs_p": "p.Thr308Ile",
"transcript": "ENST00000958804.1",
"protein_id": "ENSP00000628863.1",
"transcript_support_level": null,
"aa_start": 308,
"aa_end": null,
"aa_length": 371,
"cds_start": 923,
"cds_end": null,
"cds_length": 1116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958804.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.902C>T",
"hgvs_p": "p.Thr301Ile",
"transcript": "NM_001330220.3",
"protein_id": "NP_001317149.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 364,
"cds_start": 902,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001330220.3"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.902C>T",
"hgvs_p": "p.Thr301Ile",
"transcript": "ENST00000525493.5",
"protein_id": "ENSP00000433112.1",
"transcript_support_level": 2,
"aa_start": 301,
"aa_end": null,
"aa_length": 364,
"cds_start": 902,
"cds_end": null,
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"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000525493.5"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.902C>T",
"hgvs_p": "p.Thr301Ile",
"transcript": "ENST00000903516.1",
"protein_id": "ENSP00000573575.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 364,
"cds_start": 902,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903516.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DKK3",
"gene_hgnc_id": 2893,
"hgvs_c": "c.902C>T",
"hgvs_p": "p.Thr301Ile",
"transcript": "ENST00000903523.1",
"protein_id": "ENSP00000573582.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 364,
"cds_start": 902,
"cds_end": null,
"cds_length": 1095,
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