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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-123519517-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=123519517&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 123519517,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000635736.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GRAMD1B",
"gene_hgnc_id": 29214,
"hgvs_c": "c.452+38624C>T",
"hgvs_p": null,
"transcript": "NM_001387025.1",
"protein_id": "NP_001373954.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 877,
"cds_start": -4,
"cds_end": null,
"cds_length": 2634,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8330,
"mane_select": "ENST00000635736.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GRAMD1B",
"gene_hgnc_id": 29214,
"hgvs_c": "c.452+38624C>T",
"hgvs_p": null,
"transcript": "ENST00000635736.2",
"protein_id": "ENSP00000490062.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 877,
"cds_start": -4,
"cds_end": null,
"cds_length": 2634,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8330,
"mane_select": "NM_001387025.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GRAMD1B",
"gene_hgnc_id": 29214,
"hgvs_c": "c.452+38624C>T",
"hgvs_p": null,
"transcript": "NM_001387024.1",
"protein_id": "NP_001373953.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 901,
"cds_start": -4,
"cds_end": null,
"cds_length": 2706,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8402,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GRAMD1B",
"gene_hgnc_id": 29214,
"hgvs_c": "c.449+38624C>T",
"hgvs_p": null,
"transcript": "NM_001387026.1",
"protein_id": "NP_001373955.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 876,
"cds_start": -4,
"cds_end": null,
"cds_length": 2631,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8327,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "GRAMD1B",
"gene_hgnc_id": 29214,
"hgvs_c": "c.320+38624C>T",
"hgvs_p": null,
"transcript": "NM_001367421.2",
"protein_id": "NP_001354350.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 833,
"cds_start": -4,
"cds_end": null,
"cds_length": 2502,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8136,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GRAMD1B",
"gene_hgnc_id": 29214,
"hgvs_c": "c.104+38624C>T",
"hgvs_p": null,
"transcript": "NM_001367420.2",
"protein_id": "NP_001354349.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 789,
"cds_start": -4,
"cds_end": null,
"cds_length": 2370,
"cdna_start": null,
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"cdna_length": 7894,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GRAMD1B",
"gene_hgnc_id": 29214,
"hgvs_c": "c.110+27558C>T",
"hgvs_p": null,
"transcript": "ENST00000638086.1",
"protein_id": "ENSP00000490920.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 767,
"cds_start": -4,
"cds_end": null,
"cds_length": 2304,
"cdna_start": null,
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"cdna_length": 2665,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GRAMD1B",
"gene_hgnc_id": 29214,
"hgvs_c": "c.104+38624C>T",
"hgvs_p": null,
"transcript": "NM_001367419.2",
"protein_id": "NP_001354348.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 765,
"cds_start": -4,
"cds_end": null,
"cds_length": 2298,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7822,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GRAMD1B",
"gene_hgnc_id": 29214,
"hgvs_c": "c.104+38624C>T",
"hgvs_p": null,
"transcript": "NM_001367418.2",
"protein_id": "NP_001354347.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 761,
"cds_start": -4,
"cds_end": null,
"cds_length": 2286,
"cdna_start": null,
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"cdna_length": 7810,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GRAMD1B",
"gene_hgnc_id": 29214,
"hgvs_c": "c.-98+38624C>T",
"hgvs_p": null,
"transcript": "NM_001387030.1",
"protein_id": "NP_001373959.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 21,
"intron_rank": 2,
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"gene_symbol": "GRAMD1B",
"gene_hgnc_id": 29214,
"hgvs_c": "c.-98+8821C>T",
"hgvs_p": null,
"transcript": "NM_001387032.1",
"protein_id": "NP_001373961.1",
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},
{
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"consequences": [
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],
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"gene_symbol": "GRAMD1B",
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},
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],
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"gene_symbol": "GRAMD1B",
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"hgvs_c": "c.-98+8821C>T",
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"transcript": "NM_001330396.3",
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},
{
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],
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"gene_symbol": "GRAMD1B",
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"transcript": "NM_001387034.1",
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},
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],
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"gene_symbol": "GRAMD1B",
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"hgvs_c": "c.-98+38624C>T",
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"transcript": "ENST00000638157.1",
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},
{
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],
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"gene_symbol": "GRAMD1B",
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},
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],
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"gene_symbol": "GRAMD1B",
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"transcript": "ENST00000633646.1",
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},
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],
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"gene_symbol": "GRAMD1B",
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"hgvs_c": "c.-98+9480C>T",
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"transcript": "ENST00000632815.1",
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},
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],
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"gene_symbol": "GRAMD1B",
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"hgvs_c": "c.452+38624C>T",
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},
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],
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},
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],
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"gene_symbol": "GRAMD1B",
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"hgvs_c": "c.404+38624C>T",
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},
{
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"consequences": [
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],
"exon_rank": null,
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"exon_count": 22,
"intron_rank": 3,
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"gene_symbol": "GRAMD1B",
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"hgvs_c": "c.407+38624C>T",
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