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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-125481576-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=125481576&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 125481576,
"ref": "A",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_005103.5",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "NM_005103.5",
"protein_id": "NP_005094.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 392,
"cds_start": 369,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000278919.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005103.5"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000278919.8",
"protein_id": "ENSP00000278919.3",
"transcript_support_level": 1,
"aa_start": 123,
"aa_end": null,
"aa_length": 392,
"cds_start": 369,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005103.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000278919.8"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000965005.1",
"protein_id": "ENSP00000635064.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 409,
"cds_start": 369,
"cds_end": null,
"cds_length": 1230,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965005.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000863680.1",
"protein_id": "ENSP00000533739.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 401,
"cds_start": 369,
"cds_end": null,
"cds_length": 1206,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863680.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000863686.1",
"protein_id": "ENSP00000533745.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 401,
"cds_start": 369,
"cds_end": null,
"cds_length": 1206,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863686.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000648911.1",
"protein_id": "ENSP00000497070.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 392,
"cds_start": 369,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000648911.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000863673.1",
"protein_id": "ENSP00000533732.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 392,
"cds_start": 369,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863673.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000863674.1",
"protein_id": "ENSP00000533733.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 392,
"cds_start": 369,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863674.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000863675.1",
"protein_id": "ENSP00000533734.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 392,
"cds_start": 369,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863675.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000863679.1",
"protein_id": "ENSP00000533738.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 392,
"cds_start": 369,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863679.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000863685.1",
"protein_id": "ENSP00000533744.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 392,
"cds_start": 369,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863685.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000936093.1",
"protein_id": "ENSP00000606152.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 392,
"cds_start": 369,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936093.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000936094.1",
"protein_id": "ENSP00000606153.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 392,
"cds_start": 369,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936094.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000936095.1",
"protein_id": "ENSP00000606154.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 392,
"cds_start": 369,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936095.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000964998.1",
"protein_id": "ENSP00000635057.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 392,
"cds_start": 369,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000964998.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000965001.1",
"protein_id": "ENSP00000635060.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 392,
"cds_start": 369,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965001.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000965007.1",
"protein_id": "ENSP00000635066.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 392,
"cds_start": 369,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965007.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000964999.1",
"protein_id": "ENSP00000635058.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 380,
"cds_start": 369,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000964999.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000863678.1",
"protein_id": "ENSP00000533737.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 370,
"cds_start": 369,
"cds_end": null,
"cds_length": 1113,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863678.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000965006.1",
"protein_id": "ENSP00000635065.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 370,
"cds_start": 369,
"cds_end": null,
"cds_length": 1113,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965006.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000863677.1",
"protein_id": "ENSP00000533736.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 365,
"cds_start": 369,
"cds_end": null,
"cds_length": 1098,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863677.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FEZ1",
"gene_hgnc_id": 3659,
"hgvs_c": "c.369T>A",
"hgvs_p": "p.Asp123Glu",
"transcript": "ENST00000863676.1",
"protein_id": "ENSP00000533735.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 363,
"cds_start": 369,
"cds_end": null,
"cds_length": 1092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863676.1"
},
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}