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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-134303852-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=134303852&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 134303852,
"ref": "T",
"alt": "G",
"effect": "intron_variant",
"transcript": "NM_001080407.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.877-3272T>G",
"hgvs_p": null,
"transcript": "NM_001080407.3",
"protein_id": "NP_001073876.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 653,
"cds_start": null,
"cds_end": null,
"cds_length": 1962,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000431683.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001080407.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.877-3272T>G",
"hgvs_p": null,
"transcript": "ENST00000431683.7",
"protein_id": "ENSP00000396615.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 653,
"cds_start": null,
"cds_end": null,
"cds_length": 1962,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001080407.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000431683.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.877-1263T>G",
"hgvs_p": null,
"transcript": "ENST00000389887.9",
"protein_id": "ENSP00000374537.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 313,
"cds_start": null,
"cds_end": null,
"cds_length": 942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000389887.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.877-3272T>G",
"hgvs_p": null,
"transcript": "ENST00000927565.1",
"protein_id": "ENSP00000597624.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 654,
"cds_start": null,
"cds_end": null,
"cds_length": 1965,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927565.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.868-3272T>G",
"hgvs_p": null,
"transcript": "ENST00000927563.1",
"protein_id": "ENSP00000597622.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 650,
"cds_start": null,
"cds_end": null,
"cds_length": 1953,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927563.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.841-3272T>G",
"hgvs_p": null,
"transcript": "ENST00000927556.1",
"protein_id": "ENSP00000597615.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 641,
"cds_start": null,
"cds_end": null,
"cds_length": 1926,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927556.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.877-3272T>G",
"hgvs_p": null,
"transcript": "ENST00000927561.1",
"protein_id": "ENSP00000597620.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 626,
"cds_start": null,
"cds_end": null,
"cds_length": 1881,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927561.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.841-3272T>G",
"hgvs_p": null,
"transcript": "ENST00000927562.1",
"protein_id": "ENSP00000597621.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 614,
"cds_start": null,
"cds_end": null,
"cds_length": 1845,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927562.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.877-3272T>G",
"hgvs_p": null,
"transcript": "ENST00000927564.1",
"protein_id": "ENSP00000597623.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 607,
"cds_start": null,
"cds_end": null,
"cds_length": 1824,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927564.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.919-8497T>G",
"hgvs_p": null,
"transcript": "ENST00000927560.1",
"protein_id": "ENSP00000597619.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 530,
"cds_start": null,
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"cds_length": 1593,
"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000927560.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.877-8497T>G",
"hgvs_p": null,
"transcript": "ENST00000927557.1",
"protein_id": "ENSP00000597616.1",
"transcript_support_level": null,
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"cds_start": null,
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"feature": "ENST00000927557.1"
},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"gene_symbol": "GLB1L3",
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"hgvs_c": "c.841-8497T>G",
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"transcript": "ENST00000927558.1",
"protein_id": "ENSP00000597617.1",
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"cds_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000927558.1"
},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 9,
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"gene_symbol": "GLB1L3",
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"hgvs_c": "c.876+10643T>G",
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"transcript": "ENST00000927559.1",
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"cdna_start": null,
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"feature": "ENST00000927559.1"
},
{
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": 8,
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"gene_symbol": "GLB1L3",
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"transcript": "XM_011542566.3",
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"biotype": "protein_coding",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.1018-3272T>G",
"hgvs_p": null,
"transcript": "XM_011542567.3",
"protein_id": "XP_011540869.1",
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"biotype": "protein_coding",
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},
{
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"protein_coding": true,
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],
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"exon_count": 19,
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"gene_symbol": "GLB1L3",
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"hgvs_c": "c.982-3272T>G",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": 9,
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"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.841-3272T>G",
"hgvs_p": null,
"transcript": "XM_017017155.3",
"protein_id": "XP_016872644.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 15,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.1018-8497T>G",
"hgvs_p": null,
"transcript": "XM_011542569.3",
"protein_id": "XP_011540871.1",
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},
{
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"strand": true,
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],
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"intron_rank": 8,
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"gene_symbol": "GLB1L3",
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},
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],
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"gene_symbol": "GLB1L3",
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"hgvs_c": "c.1018-3272T>G",
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},
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],
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"intron_rank": 8,
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"gene_symbol": "GLB1L3",
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"hgvs_c": "c.1018-3272T>G",
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"transcript": "XM_011542571.3",
"protein_id": "XP_011540873.1",
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"biotype": "protein_coding",
"feature": "XM_011542571.3"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GLB1L3",
"gene_hgnc_id": 25147,
"hgvs_c": "c.877-8497T>G",
"hgvs_p": null,
"transcript": "XM_017017156.3",
"protein_id": "XP_016872645.1",
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"aa_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_017017156.3"
},
{
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}
],
"message": null
}