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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-17394334-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=17394334&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "11",
      "pos": 17394334,
      "ref": "G",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_001351295.2",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.4477C>G",
          "hgvs_p": "p.Arg1493Gly",
          "transcript": "NM_000352.6",
          "protein_id": "NP_000343.2",
          "transcript_support_level": null,
          "aa_start": 1493,
          "aa_end": null,
          "aa_length": 1581,
          "cds_start": 4477,
          "cds_end": null,
          "cds_length": 4746,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000389817.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_000352.6"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.4477C>G",
          "hgvs_p": "p.Arg1493Gly",
          "transcript": "ENST00000389817.8",
          "protein_id": "ENSP00000374467.4",
          "transcript_support_level": 1,
          "aa_start": 1493,
          "aa_end": null,
          "aa_length": 1581,
          "cds_start": 4477,
          "cds_end": null,
          "cds_length": 4746,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_000352.6",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000389817.8"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.4543C>G",
          "hgvs_p": "p.Arg1515Gly",
          "transcript": "NM_001351295.2",
          "protein_id": "NP_001338224.1",
          "transcript_support_level": null,
          "aa_start": 1515,
          "aa_end": null,
          "aa_length": 1603,
          "cds_start": 4543,
          "cds_end": null,
          "cds_length": 4812,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001351295.2"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.4543C>G",
          "hgvs_p": "p.Arg1515Gly",
          "transcript": "ENST00000644772.1",
          "protein_id": "ENSP00000494321.1",
          "transcript_support_level": null,
          "aa_start": 1515,
          "aa_end": null,
          "aa_length": 1603,
          "cds_start": 4543,
          "cds_end": null,
          "cds_length": 4812,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000644772.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.4480C>G",
          "hgvs_p": "p.Arg1494Gly",
          "transcript": "NM_001287174.3",
          "protein_id": "NP_001274103.1",
          "transcript_support_level": null,
          "aa_start": 1494,
          "aa_end": null,
          "aa_length": 1582,
          "cds_start": 4480,
          "cds_end": null,
          "cds_length": 4749,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001287174.3"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.4480C>G",
          "hgvs_p": "p.Arg1494Gly",
          "transcript": "ENST00000302539.9",
          "protein_id": "ENSP00000303960.4",
          "transcript_support_level": 5,
          "aa_start": 1494,
          "aa_end": null,
          "aa_length": 1582,
          "cds_start": 4480,
          "cds_end": null,
          "cds_length": 4749,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000302539.9"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.4477C>G",
          "hgvs_p": "p.Arg1493Gly",
          "transcript": "NM_001351296.2",
          "protein_id": "NP_001338225.1",
          "transcript_support_level": null,
          "aa_start": 1493,
          "aa_end": null,
          "aa_length": 1581,
          "cds_start": 4477,
          "cds_end": null,
          "cds_length": 4746,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001351296.2"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.4477C>G",
          "hgvs_p": "p.Arg1493Gly",
          "transcript": "ENST00000643260.1",
          "protein_id": "ENSP00000494450.1",
          "transcript_support_level": null,
          "aa_start": 1493,
          "aa_end": null,
          "aa_length": 1581,
          "cds_start": 4477,
          "cds_end": null,
          "cds_length": 4746,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000643260.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.4474C>G",
          "hgvs_p": "p.Arg1492Gly",
          "transcript": "NM_001351297.2",
          "protein_id": "NP_001338226.1",
          "transcript_support_level": null,
          "aa_start": 1492,
          "aa_end": null,
          "aa_length": 1580,
          "cds_start": 4474,
          "cds_end": null,
          "cds_length": 4743,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001351297.2"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.4474C>G",
          "hgvs_p": "p.Arg1492Gly",
          "transcript": "ENST00000642271.1",
          "protein_id": "ENSP00000493749.1",
          "transcript_support_level": null,
          "aa_start": 1492,
          "aa_end": null,
          "aa_length": 1580,
          "cds_start": 4474,
          "cds_end": null,
          "cds_length": 4743,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000642271.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.4444C>G",
          "hgvs_p": "p.Arg1482Gly",
          "transcript": "ENST00000646902.1",
          "protein_id": "ENSP00000494101.1",
          "transcript_support_level": null,
          "aa_start": 1482,
          "aa_end": null,
          "aa_length": 1570,
          "cds_start": 4444,
          "cds_end": null,
          "cds_length": 4713,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000646902.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 36,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.4360C>G",
          "hgvs_p": "p.Arg1454Gly",
          "transcript": "ENST00000683136.1",
          "protein_id": "ENSP00000507768.1",
          "transcript_support_level": null,
          "aa_start": 1454,
          "aa_end": null,
          "aa_length": 1542,
          "cds_start": 4360,
          "cds_end": null,
          "cds_length": 4629,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000683136.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 36,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.4318C>G",
          "hgvs_p": "p.Arg1440Gly",
          "transcript": "ENST00000684571.1",
          "protein_id": "ENSP00000506935.1",
          "transcript_support_level": null,
          "aa_start": 1440,
          "aa_end": null,
          "aa_length": 1528,
          "cds_start": 4318,
          "cds_end": null,
          "cds_length": 4587,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000684571.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.4228C>G",
          "hgvs_p": "p.Arg1410Gly",
          "transcript": "ENST00000647015.1",
          "protein_id": "ENSP00000495389.1",
          "transcript_support_level": null,
          "aa_start": 1410,
          "aa_end": null,
          "aa_length": 1498,
          "cds_start": 4228,
          "cds_end": null,
          "cds_length": 4497,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000647015.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 25,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.2530C>G",
          "hgvs_p": "p.Arg844Gly",
          "transcript": "ENST00000642579.1",
          "protein_id": "ENSP00000496714.1",
          "transcript_support_level": null,
          "aa_start": 844,
          "aa_end": null,
          "aa_length": 932,
          "cds_start": 2530,
          "cds_end": null,
          "cds_length": 2799,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000642579.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "c.1066C>G",
          "hgvs_p": "p.Arg356Gly",
          "transcript": "ENST00000528374.2",
          "protein_id": "ENSP00000433638.2",
          "transcript_support_level": 5,
          "aa_start": 356,
          "aa_end": null,
          "aa_length": 444,
          "cds_start": 1066,
          "cds_end": null,
          "cds_length": 1335,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000528374.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "n.4078C>G",
          "hgvs_p": null,
          "transcript": "ENST00000524561.2",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000524561.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "n.372C>G",
          "hgvs_p": null,
          "transcript": "ENST00000525022.1",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000525022.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "n.412C>G",
          "hgvs_p": null,
          "transcript": "ENST00000526037.6",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000526037.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ABCC8",
          "gene_hgnc_id": 59,
          "hgvs_c": "n.*164C>G",
          "hgvs_p": null,
          "transcript": "ENST00000526168.5",
          "protein_id": "ENSP00000437233.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
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      "computational_score_selected": 0.9887200593948364,
      "computational_prediction_selected": "Pathogenic",
      "computational_source_selected": "MetaRNN",
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      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
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      "acmg_classification": "Likely_pathogenic",
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          "transcript": "NM_001351295.2",
          "gene_symbol": "ABCC8",
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          "hgvs_p": "p.Arg1515Gly"
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      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.